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- Tasks: Join our Protein Engineering team to develop innovative cancer treatments through advanced T-cell therapies.
- Company: Yellowstone Biosciences, a pioneering biotech spinout from the University of Oxford.
- Benefits: Gain hands-on experience in a collaborative environment with opportunities for professional growth.
- Why this job: Make a real impact in cancer research while working with cutting-edge molecular biology techniques.
- Qualifications: MSc, PhD or equivalent in Molecular Biology or Biochemistry; experience in modern techniques required.
- Other info: Embrace diversity and inclusivity in a fast-paced, dynamic biotech setting.
The predicted salary is between 36000 - 60000 £ per year.
About the Company
Yellowstone Biosciences is a biotechnology spinout company located in Oxford, whose goal is to pioneer new cancer treatments using advanced T-cell therapies based on groundbreaking research from the MRC Weatherall Institute of Molecular Medicine at the University of Oxford.
About the Role
We are seeking a Senior Scientist / Scientist to work within our Protein Engineering team to provide essential hands-on support to accelerate our pipeline of novel therapeutics. This role is focussed on affinity enhancement of TCRs towards novel ligands and the downstream characterisation of output clones. In addition, there will be the opportunity to gain broad experience across molecular biology, display technologies, expression, purification, and early-stage discovery in a fast-paced & collaborative biotech environment. The role is available as a fixed term contract (6 month) in the first instance.
Responsibilities
- Engineering and affinity maturation of TCRs against novel targets using phage display
- Molecular biology - Library construction & reformatting output into expression constructs
- Recombinant protein expression of affinity enhanced proteins in mammalian systems (Expi293 and ExpiCHO)
- Transient transfection
- Protein purification
- Protein characterisation SDS-PAGE, Western blotting and DSF
- Protein binding assays SPR, BLI, ELISA
Qualifications
- MSc, PhD or equivalent in Molecular Biology or Biochemistry or a related subject
- Seniority grade will be dependent on experience
Required Skills
- Experienced in modern molecular biology techniques and relevant software packages (SnapGene, Benchling etc.)
- DNA library construction of highly diverse sequences
- Display technologies (eg. phage display) for TCR/Antibody affinity maturation
- Protein purification and protein analysis
- Flexibility and willingness to learn new techniques and adopt new practices to support the company goals
- Accuracy, efficiency and attention to detail is essential
- Excellent communication and record-keeping skills
- Work in accordance with company Health and Safety policies, with particular emphasis on laboratory safety standards
Preferred Skills
- TCR protein production
- Experience of mammalian cell culture and excellent aseptic technique
- Understanding of protein structure/function relationships
- Experience working in a fast-paced environment
Equal Opportunity Statement: We are committed to diversity and inclusivity.
Senior Scientist Protein Engineering in Oxford employer: Yellowstone Biosciences
Contact Detail:
Yellowstone Biosciences Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Scientist Protein Engineering in Oxford
✨Tip Number 1
Network like a pro! Reach out to people in the biotech field, especially those working at companies like Yellowstone Biosciences. A friendly chat can open doors and give you insights that job descriptions just can't.
✨Tip Number 2
Prepare for interviews by brushing up on your technical skills and being ready to discuss your past projects. We want to see how your experience aligns with their needs, so be specific about your contributions and results.
✨Tip Number 3
Show your passion for the role! When you get the chance to speak with them, let your enthusiasm for protein engineering and cancer research shine through. It’s all about making a connection beyond just qualifications.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen. Plus, we love seeing candidates who take that extra step to engage with us directly.
We think you need these skills to ace Senior Scientist Protein Engineering in Oxford
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the role of Senior Scientist in Protein Engineering. Highlight your experience with molecular biology techniques and any relevant projects that showcase your skills in affinity maturation and protein purification.
Craft a Compelling Cover Letter: Your cover letter should tell us why you're passionate about cancer research and how your background aligns with our mission at Yellowstone Biosciences. Be sure to mention specific experiences that demonstrate your expertise in TCR engineering and related technologies.
Showcase Your Skills: Don’t just list your skills; provide examples of how you've used them in past roles. Whether it’s your experience with phage display or your proficiency in software like SnapGene, we want to see how you’ve applied these skills in real-world scenarios.
Apply Through Our Website: We encourage you to apply through our website for a smoother application process. This way, you can ensure all your documents are submitted correctly and you’ll be kept in the loop about your application status!
How to prepare for a job interview at Yellowstone Biosciences
✨Know Your Science
Make sure you brush up on the latest techniques in molecular biology and protein engineering. Be ready to discuss your experience with TCR affinity maturation and any relevant projects you've worked on. This shows you're not just familiar with the theory but can apply it practically.
✨Showcase Your Skills
Prepare to talk about specific molecular biology techniques you've mastered, like phage display or protein purification. Bring examples of how you've used these skills in past roles, as this will demonstrate your hands-on experience and problem-solving abilities.
✨Be Ready for Technical Questions
Expect some deep dives into your technical knowledge. Brush up on topics like SDS-PAGE, Western blotting, and binding assays. Practising answers to common technical questions can help you feel more confident during the interview.
✨Emphasise Teamwork and Communication
Since this role involves collaboration, be prepared to discuss how you've worked effectively in teams before. Highlight your communication skills and how you keep detailed records, as these are crucial in a fast-paced biotech environment.