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- Tasks: Join our Protein Engineering team to develop innovative cancer treatments using advanced T-cell therapies.
- Company: Yellowstone Biosciences, a pioneering biotech spinout from the University of Oxford.
- Benefits: Gain hands-on experience in a collaborative environment with opportunities for professional growth.
- Why this job: Make a real impact in cancer research while working with cutting-edge molecular biology techniques.
- Qualifications: MSc or PhD in Molecular Biology or Biochemistry; experience in modern molecular biology techniques required.
- Other info: Fixed-term contract with potential for dynamic career development in a fast-paced setting.
The predicted salary is between 36000 - 60000 £ per year.
Yellowstone Biosciences is a biotechnology spinout company located in Oxford, whose goal is to pioneer new cancer treatments using advanced T-cell therapies based on groundbreaking research from the MRC Weatherall Institute of Molecular Medicine at the University of Oxford.
About the Role
We are seeking a Senior Scientist / Scientist to work within our Protein Engineering team to provide essential hands‑on support to accelerate our pipeline of novel therapeutics. This role is focussed on affinity enhancement of TCRs towards novel ligands and the downstream characterisation of output clones. In addition, there will be the opportunity to gain broad experience across molecular biology, display technologies, expression, purification, and early‑stage discovery in a fast‑paced & collaborative biotech environment. The role is available as a fixed term contract (6 month) in the first instance.
Responsibilities
- Engineering and affinity maturation of TCRs against novel targets using phage display
- Molecular biology - Library construction & reformatting output into expression constructs
- Recombinant protein expression of affinity enhanced proteins in mammalian systems (Expi293 and ExpiCHO)
- Transient transfection
- Protein characterisation SDS‑PAGE, Western blotting and DSF
Qualifications
- MSc, PhD or equivalent in Molecular Biology or Biochemistry or a related subject
- Seniority grade will be dependent on experience
Required Skills
- Experienced in modern molecular biology techniques and relevant software packages (SnapGene, Benchling etc.)
- DNA library construction of highly diverse sequences
- Display technologies (eg. phage display) for TCR/Antibody affinity maturation
- Protein purification and protein analysis
- Flexibility and willingness to learn new techniques and adopt new practices to support the company goals
- Accuracy, efficiency and attention to detail is essential
- Excellent communication and record-keeping skills
- Work in accordance with company Health and Safety policies, with particular emphasis on laboratory safety standards
Preferred Skills
- Experience of mammalian cell culture and excellent aseptic technique
- Understanding of protein structure/function relationships
- Experience working in a fast‑paced environment
Equal Opportunity Statement
We are committed to diversity and inclusivity.
Scientist / Senior Scientist Protein Engineer in Oxford employer: Yellowstone Biosciences
Contact Detail:
Yellowstone Biosciences Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Scientist / Senior Scientist Protein Engineer in Oxford
✨Tip Number 1
Network like a pro! Reach out to people in the biotech field, especially those working at Yellowstone Biosciences. A friendly chat can open doors and give you insights that a job description just can't.
✨Tip Number 2
Prepare for interviews by brushing up on your molecular biology techniques and relevant software. Be ready to discuss your experience with TCR affinity maturation and protein characterisation – show them you're the perfect fit!
✨Tip Number 3
Don’t forget to showcase your flexibility and willingness to learn. In a fast-paced environment like Yellowstone, they’ll appreciate someone who can adapt and pick up new techniques quickly.
✨Tip Number 4
Apply through our website! It’s the best way to ensure your application gets seen. Plus, it shows you’re genuinely interested in being part of our mission to pioneer new cancer treatments.
We think you need these skills to ace Scientist / Senior Scientist Protein Engineer in Oxford
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the role of Scientist/Senior Scientist. Highlight your experience with molecular biology techniques and any relevant projects that showcase your skills in protein engineering. We want to see how you fit into our team!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about cancer research and how your background aligns with our mission at Yellowstone Biosciences. Keep it engaging and personal – we love to see your personality!
Showcase Relevant Skills: Be sure to emphasise your experience with phage display, protein purification, and any software tools like SnapGene or Benchling. We’re looking for candidates who can hit the ground running, so make those skills pop in your application!
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way to ensure your application gets to us quickly and efficiently. Plus, it shows you’re keen on joining our team at Yellowstone Biosciences!
How to prepare for a job interview at Yellowstone Biosciences
✨Know Your Science
Make sure you brush up on the latest advancements in molecular biology and protein engineering. Be ready to discuss your experience with techniques like phage display and protein purification, as these are crucial for the role.
✨Showcase Your Skills
Prepare to talk about specific projects where you've used modern molecular biology techniques. Highlight your experience with software like SnapGene and Benchling, and be ready to explain how you've applied these tools in real-world scenarios.
✨Demonstrate Flexibility
This role requires a willingness to learn and adapt. Think of examples from your past where you've successfully picked up new techniques or adjusted to fast-paced environments, and be prepared to share those stories.
✨Communicate Clearly
Excellent communication is key in a collaborative biotech setting. Practice explaining complex scientific concepts in simple terms, and ensure you can articulate your thought process clearly during the interview.