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- Tasks: Join our Protein Production team to support groundbreaking cancer therapies through hands-on science.
- Company: Yellowstone Biosciences, an innovative biotech spinout from the University of Oxford.
- Benefits: Gain valuable experience in a fast-paced environment with potential for career growth.
- Why this job: Make a real difference in cancer treatment while working with cutting-edge technology.
- Qualifications: PhD or equivalent in Biochemistry; experience in mammalian cell culture and protein production.
- Other info: Fixed-term contract with opportunities to learn and develop new skills.
The predicted salary is between 36000 - 60000 £ per year.
About the Company
Yellowstone Biosciences is a biotechnology spinout company located in Oxford, whose goal is to pioneer new cancer treatments using advanced T-cell therapies based on groundbreaking research from the MRC Weatherall Institute of Molecular Medicine at the University of Oxford.
About the Role
We are seeking two Scientists to work within our Protein Production team to provide essential hands-on support to accelerate our pipeline of novel therapeutics. A main aspect of one of these roles is to take responsibility for maintaining and optimising the mammalian expression pipeline; this is a key deliverable. Both roles require protein purification, characterisation and affinity measurements. There will be opportunity to gain broad experience across therapeutic protein design and characterisation in a fast-paced and collaborative biotech environment. The role is available as a fixed term contract (6 month) in the first instance.
Responsibilities
- Recombinant protein expression in mammalian systems
- Cell maintenance and expansion in preparation for transfection for the Protein Science team
- Transient transfection
- Stable cell line generation
- Protein purification (Bench and FPLC methods)
- Protein characterisation (SDS-PAGE, Western blotting and DSF)
- Protein binding assays (SPR, BLI, ELISA)
- Molecular biology Expression construct design and cloning
Qualifications
- PhD (or equivalent experience) in Biochemistry or a related subject
Required Skills
- Experience of mammalian cell culture and excellent aseptic technique (for mammalian expression role)
- Excellent knowledge of protein production techniques and workflows
- Molecular cloning
- Experience of AKTA FPLC use including method writing and optimisation
- Flexibility and willingness to learn new techniques and adopt new practices to support the company goals
- Accuracy, efficiency and attention to detail is essential
- Excellent communication and record-keeping skills
- Work in accordance with company Health and Safety policies, with particular emphasis on laboratory safety standards
- Experience using relevant software packages e.g. SnapGene, Benchling
Preferred Skills
- TCR and pHLA protein production
- Protein refolding
- Biophysical characterisation SPR and/or BLI
- ELISA
- Thermal shift assay
Protein production scientist in Oxford employer: Yellowstone Biosciences
Contact Detail:
Yellowstone Biosciences Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Protein production scientist in Oxford
✨Tip Number 1
Network like a pro! Reach out to people in the biotech field, especially those working at Yellowstone Biosciences. A friendly chat can open doors and give you insights that might just land you an interview.
✨Tip Number 2
Show off your skills! Prepare a portfolio or a presentation that highlights your experience with protein production techniques and workflows. This will help you stand out during interviews and showcase your hands-on expertise.
✨Tip Number 3
Practice makes perfect! Get comfortable with common interview questions related to mammalian cell culture and protein purification. We recommend doing mock interviews with friends or colleagues to boost your confidence.
✨Tip Number 4
Apply through our website! It’s the best way to ensure your application gets noticed. Plus, it shows you're genuinely interested in joining the team at Yellowstone Biosciences.
We think you need these skills to ace Protein production scientist in Oxford
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the Protein Production Scientist role. Highlight your experience with mammalian cell culture, protein purification, and any relevant techniques like FPLC or ELISA. We want to see how your skills match what we're looking for!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about cancer research and how your background makes you a great fit for our team. Keep it concise but engaging – we love a good story!
Show Off Your Skills: Don’t just list your skills; demonstrate them! If you've got experience with specific techniques mentioned in the job description, like SDS-PAGE or Western blotting, make sure to include examples of how you've used them in your previous roles.
Apply Through Our Website: We encourage you to apply through our website for a smoother application process. It helps us keep everything organised and ensures your application gets the attention it deserves. Plus, it’s super easy!
How to prepare for a job interview at Yellowstone Biosciences
✨Know Your Proteins
Make sure you brush up on your knowledge of protein production techniques and workflows. Be ready to discuss your experience with mammalian cell culture, purification methods, and any relevant software like SnapGene or Benchling. This will show that you're not just familiar with the theory but have practical insights too.
✨Showcase Your Aseptic Technique
Since excellent aseptic technique is crucial for this role, be prepared to talk about your experiences in maintaining sterile conditions during cell culture. You might even want to share specific examples where your attention to detail made a difference in your results.
✨Demonstrate Flexibility and Learning
Highlight your willingness to learn new techniques and adapt to the fast-paced environment at Yellowstone Biosciences. Share instances where you've successfully picked up new skills or adapted your approach to meet project goals, as this will resonate well with their collaborative culture.
✨Communicate Clearly
Strong communication skills are essential, so practice articulating your thoughts clearly and concisely. Be ready to explain complex concepts in a way that's easy to understand, and don’t forget to ask insightful questions about the team and projects to show your genuine interest.