Find a job 
Featured Companies 
Featured Universities 
For Companies At a Glance
- Tasks: Lead a team in characterising T cell activation and bi-specific TCR molecules.
- Company: Join a pioneering biotech firm focused on innovative cancer therapies.
- Benefits: Enjoy competitive salary, flexible working hours, and opportunities for professional growth.
- Why this job: Make a real impact in immunology while leading a passionate team in cutting-edge research.
- Qualifications: PhD in biology with 5+ years in biotech or pharma R&D; strong lab and leadership skills required.
- Other info: Potential for team expansion and collaboration with top industry leaders.
The predicted salary is between 48000 - 72000 £ per year.
The successful candidate will be accountable for the successful and appropriate in vitro and in vivo characterisation of binding specificity of candidate and T cell activation and T cell-mediated killing of bi-specific TCR molecules to cells. This role requires strong team leadership, scientific understanding, and expertise in immunology, T cell assays, cellular biology, and molecular biology. Experience with lentiviral transduction and cloning is desirable.
You will have responsibility for leading the day-to-day running of the preclinical biology group.
Key Responsibilities- Lead the day-to-day operations of the preclinical biology group.
- Develop and implement biological assays to ensure candidate soluble TCRs translate to potent and safe clinical molecules.
- Oversee all biological testing activities related to soluble TCR molecules generated by the Protein Engineering team.
- Manage a team of cell biologists, initially comprising 3-4 individuals, with potential for team expansion as candidate targets are nominated.
- Determine and implement appropriate in vitro testing strategies for efficacy, safety, and underlying molecular mechanisms of soluble TCRs, including establishing assays and sourcing cell lines and tissue samples.
- In the future there may be the opportunity to implement appropriate in vivo testing strategies, utilising outsourced resources if required.
- Collaborate effectively with the leadership team, including the Head of Protein Engineering and Head of Protein Production, to guide optimization and development of clinical soluble TCRs.
- PhD in a relevant biological subject with at least 5 years of subsequent biotechnology and/or pharmaceutical industry experience in R&D teams.
- Direct hands-on laboratory experience in testing the safety and efficacy of soluble high-affinity TCR molecules.
- Deep familiarity with traditional cell biology and molecular biology techniques, including cell binding assays, T cell activation, and T cell killing both in vitro and in vivo.
- Experience in generating isogenic cell lines using lentiviral transduction, growing a large array of cell lines, human organoids, and primary human cells.
- Expertise in complex multi-color flow cytometry, EliSpot assays, luminometry, fluorescence, and in vivo assays of safety and efficacy.
- Proven leadership skills, including successful development and implementation of scientific strategies, and ability to work with other leaders and support staff.
- Experience in managing, mentoring, developing, and motivating teams of scientists.
- Experience in managing budgets, agreeing and delivering timelines of work, and writing reports.
- Ability to present work to the Senior Leadership Team.
- Ability to publish and present work done by your team and in partnership with other Yellowstone teams.
- Familiarity with requirements for development and submission of preclinical data packages for a Clinical Trial Authorisation to MHRA and a New Drug Application to the FDA and EMA.
Group Leader - Cell Biology employer: Yellowstone Biosciences
Contact Detail:
Yellowstone Biosciences Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Group Leader - Cell Biology
✨Tip Number 1
Network with professionals in the biotechnology and pharmaceutical industries. Attend relevant conferences or seminars where you can meet experts in cell biology and immunology, as this can lead to valuable connections and insights about the role.
✨Tip Number 2
Showcase your leadership skills by participating in team projects or initiatives within your current role. Highlight any experience you have in managing teams or mentoring others, as this is crucial for the Group Leader position.
✨Tip Number 3
Stay updated on the latest advancements in T cell therapies and bi-specific TCR molecules. Familiarise yourself with recent publications and breakthroughs in the field, as this knowledge will demonstrate your passion and commitment during interviews.
✨Tip Number 4
Prepare to discuss specific examples of your hands-on laboratory experience, particularly with techniques like lentiviral transduction and flow cytometry. Being able to articulate your practical skills will set you apart from other candidates.
We think you need these skills to ace Group Leader - Cell Biology
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in cell biology, immunology, and T cell assays. Emphasise any leadership roles you've held and specific projects that align with the responsibilities of the Group Leader position.
Craft a Compelling Cover Letter: In your cover letter, express your passion for the role and the company. Discuss your PhD and how your 5+ years of experience in biotechnology or pharmaceuticals make you a strong candidate. Mention specific skills like lentiviral transduction and team management.
Showcase Leadership Experience: Highlight your proven leadership skills by providing examples of how you've successfully managed teams and developed scientific strategies. This is crucial for the Group Leader role, so be specific about your achievements.
Demonstrate Technical Expertise: Detail your hands-on laboratory experience and familiarity with techniques such as flow cytometry and EliSpot assays. Make sure to mention any experience with preclinical data packages and regulatory submissions, as this will strengthen your application.
How to prepare for a job interview at Yellowstone Biosciences
✨Showcase Your Leadership Skills
As a Group Leader, demonstrating your leadership abilities is crucial. Prepare examples of how you've successfully managed teams in the past, highlighting your mentoring and development strategies for team members.
✨Demonstrate Technical Expertise
Be ready to discuss your hands-on experience with relevant techniques such as T cell assays, flow cytometry, and lentiviral transduction. Providing specific examples of your work will show your depth of knowledge and suitability for the role.
✨Understand the Company’s Goals
Research the company’s current projects and objectives, especially in relation to bi-specific TCR molecules. This will allow you to align your answers with their goals and demonstrate your genuine interest in contributing to their success.
✨Prepare for Collaborative Scenarios
Since collaboration with other departments is key, think of instances where you've worked cross-functionally. Be prepared to discuss how you can effectively communicate and collaborate with the Protein Engineering and Production teams.
