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- Tasks: Lead biotransformation studies and support drug discovery projects with your analytical expertise.
- Company: Vertex, a global biotech company focused on scientific innovation.
- Benefits: Competitive salary, professional development, and a collaborative work environment.
- Why this job: Make a real impact in drug discovery while driving innovation in biotransformation science.
- Qualifications: Deep knowledge of mass spectrometry and biotransformation; PhD preferred.
- Other info: On-site role with opportunities for mentorship and career growth.
The predicted salary is between 36000 - 60000 £ per year.
Vertex is seeking a highly motivated and experienced Senior Principal Biotransformation Scientist to join our Oxford team. The successful candidate will play a leading role in the delivery of biotransformation and metabolite characterization support to our drug discovery and development projects.
The successful candidate will have a deep analytical background in high resolution mass spectrometry and metabolite identification with an established track record for designing, executing and interpreting bespoke biotransformation studies. They will be responsible for the delivery of critical in vitro and in vivo biotransformation knowledge to aid medicinal chemistry design and influence key decisions impacting drug discovery and clinical development.
Key Duties and Responsibilities:- Provide mass spectrometry and metabolite identification expertise to the DMPK organization, keeping abreast of new scientific developments related to biotransformation science.
- Proactively apply deep biotransformation scientific expertise to design and deliver metabolism studies in line with DMPK and project key deliverables.
- Understand, interpret, and communicate biotransformation data to Project Representatives and key stakeholders to aid medicinal chemistry design and influence key decisions.
- Be able to troubleshoot, problem-solve and define best practice for biotransformation studies.
- Drive innovation by investigating and implementing new analytical technologies and procedures.
- Contribute to the wider global biotransformation strategy to grow biotransformation science at Vertex.
- Create internal and external networks to drive science within their discipline.
- Author study reports.
- Ensure high levels of data integrity and data accessibility.
- Provide training and mentoring to more junior biotransformation colleagues.
- Proven ability of metabolite characterisation and quantification using high resolution mass spectrometry and state-of-the-art metabolite acquisition and processing software.
- Deep knowledge of biotransformations with extensive proven experience applying this to drug discovery and development programs.
- Good understanding of in vitro and in vivo approaches used to understand biotransformation issues.
- Ability to work in a matrix environment and problem solve with an extensive track record of generating high quality data and reports.
- Excellent communication, interpersonal and team working skills.
- Track record of developing more junior biotransformation scientists.
- BSc or equivalent in relevant field (PhD desirable) or equivalent relevant working experience.
Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Senior Principal Scientist Biotransformation in Oxford employer: Vertex Pharmaceuticals
Contact Detail:
Vertex Pharmaceuticals Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Principal Scientist Biotransformation in Oxford
✨Tip Number 1
Network like a pro! Reach out to your connections in the biotransformation field and let them know you're on the lookout for opportunities. A friendly chat can lead to insider info about job openings that aren't even advertised yet.
✨Tip Number 2
Prepare for interviews by brushing up on your mass spectrometry knowledge and recent advancements in biotransformation science. We want you to shine when discussing how your expertise can drive innovation at Vertex!
✨Tip Number 3
Showcase your problem-solving skills! Be ready to share examples of how you've tackled challenges in previous roles, especially those related to metabolite identification and data integrity. This will demonstrate your fit for the Senior Principal Scientist role.
✨Tip Number 4
Don't forget to apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, it shows you're serious about joining our team at Vertex.
We think you need these skills to ace Senior Principal Scientist Biotransformation in Oxford
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your experience in biotransformation and mass spectrometry. We want to see how your skills align with the role, so don’t be shy about showcasing your relevant projects!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you’re passionate about biotransformation and how your background makes you the perfect fit for our team. Let us know what excites you about working at Vertex.
Showcase Your Problem-Solving Skills: In your application, highlight specific examples where you've tackled challenges in biotransformation studies. We love candidates who can think on their feet and drive innovation, so share those success stories!
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way to ensure your application gets into the right hands. Plus, it shows us you’re serious about joining our team!
How to prepare for a job interview at Vertex Pharmaceuticals
✨Know Your Science
Brush up on your knowledge of biotransformation and mass spectrometry. Be ready to discuss specific studies you've designed or executed, and how they contributed to drug discovery. This shows you’re not just familiar with the theory but have practical experience.
✨Communicate Clearly
Practice explaining complex biotransformation data in simple terms. You’ll need to communicate effectively with project representatives and stakeholders, so being able to break down your findings will demonstrate your expertise and teamwork skills.
✨Showcase Problem-Solving Skills
Prepare examples of challenges you've faced in biotransformation studies and how you resolved them. Vertex values innovation and troubleshooting, so highlighting your ability to think critically and adapt will set you apart.
✨Network and Collaborate
Think about how you can contribute to building internal and external networks. Be ready to discuss how you’ve collaborated with others in your field and how you plan to drive science forward at Vertex. This shows you’re a team player who’s invested in the bigger picture.
