At a Glance
- Tasks: Explore novel painkilling mechanisms and conduct groundbreaking research in a collaborative environment.
- Company: University of Warwick, a leading institution in life sciences and neuroscience.
- Benefits: Competitive salary, access to state-of-the-art facilities, and opportunities for professional growth.
- Other info: Work in a cutting-edge research facility with excellent career development prospects.
- Why this job: Join a diverse team and contribute to innovative pain research that could change lives.
- Qualifications: PhD in relevant field and a passion for neuroscience and pain research.
The predicted salary is between 36000 - 60000 £ per year.
We have discovered a novel painkilling mechanism activated by an unusual agonist of the adenosine A1 receptor (A1R). This agonist, BnOCPA, seems only to activate one of the six Gi/o Gα subunits that adenosine receptors can couple to — the Gob subunit. Since this subunit is found at low levels in the heart, BnOCPA does not affect blood pressure or heart rate, but still acts as a potent analgesic in a preclinical model of neuropathic pain.
In this project, funded by the MRC, we will investigate the cellular and molecular mechanisms of BnOCPA and a related derivative, and test BnOCPA in neuropathic and inflammatory pain models. The project involves three labs at the University of Warwick (Frenguelli, Wall and Zhang). Each group brings specific expertise to the project and different aspects will be overseen as required. The three groups are part of the Neuroscience Research Cluster in the School of Life Sciences at Warwick University.
We are a diverse group of neuroscientists who study a variety of physiological and pathological processes occurring in the nervous system. Through in silico, molecular, cellular and whole animal approaches, we investigate fundamental properties of synaptic transmission and plasticity, the influence of pathogenic proteins, and the impact and mechanisms of stress, pain and epilepsy.
The labs are located in the Interdisciplinary Biomedical Research Building (IBRB), a new £54m state-of-the-art research facility that combines cutting-edge research infrastructure with award-winning architecture.
Contact Details
- Name: Bruno Frenguelli
- Email: b.g.frenguelli@warwick.ac.uk
Further details and application information are not provided in this description.
Postdoctoral Research Fellow in Pain Research in Coventry employer: University of Warwick
The University of Warwick is an exceptional employer for those seeking a Postdoctoral Research Fellow position in Pain Research, offering a vibrant work culture that fosters collaboration and innovation within its state-of-the-art Interdisciplinary Biomedical Research Building. With a commitment to employee growth through diverse research opportunities and access to leading experts in neuroscience, the university provides a supportive environment for advancing your career while contributing to groundbreaking discoveries in pain management.
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