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- Tasks: Explore novel painkilling mechanisms and conduct groundbreaking research in a collaborative environment.
- Company: University of Warwick, a leading institution in life sciences and neuroscience.
- Benefits: Competitive salary, access to state-of-the-art facilities, and opportunities for professional growth.
- Why this job: Join a diverse team and contribute to innovative pain research that could change lives.
- Qualifications: PhD in relevant field and a passion for neuroscience and pain research.
- Other info: Work in a cutting-edge research facility with excellent career development prospects.
The predicted salary is between 36000 - 60000 £ per year.
We have discovered a novel painkilling mechanism activated by an unusual agonist of the adenosine A1 receptor (A1R). This agonist, BnOCPA, seems only to activate one of the six Gi/o Gα subunits that adenosine receptors can couple to — the Gob subunit. Since this subunit is found at low levels in the heart, BnOCPA does not affect blood pressure or heart rate, but still acts as a potent analgesic in a preclinical model of neuropathic pain.
In this project, funded by the MRC, we will investigate the cellular and molecular mechanisms of BnOCPA and a related derivative, and test BnOCPA in neuropathic and inflammatory pain models. The project involves three labs at the University of Warwick (Frenguelli, Wall and Zhang). Each group brings specific expertise to the project and different aspects will be overseen as required. The three groups are part of the Neuroscience Research Cluster in the School of Life Sciences at Warwick University.
We are a diverse group of neuroscientists who study a variety of physiological and pathological processes occurring in the nervous system. Through in silico, molecular, cellular and whole animal approaches, we investigate fundamental properties of synaptic transmission and plasticity, the influence of pathogenic proteins, and the impact and mechanisms of stress, pain and epilepsy.
The labs are located in the Interdisciplinary Biomedical Research Building (IBRB), a new £54m state-of-the-art research facility that combines cutting-edge research infrastructure with award-winning architecture.
Contact Details
- Name: Bruno Frenguelli
- Email: b.g.frenguelli@warwick.ac.uk
Further details and application information are not provided in this description.
Postdoctoral Research Fellow in Pain Research in Coventry employer: University of Warwick
Contact Detail:
University of Warwick Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Postdoctoral Research Fellow in Pain Research in Coventry
✨Tip Number 1
Network like a pro! Reach out to current or former researchers at the University of Warwick, especially those in the Neuroscience Research Cluster. A friendly chat can give you insider info and maybe even a foot in the door.
✨Tip Number 2
Show your passion for pain research! When you get the chance to speak with potential colleagues or during interviews, share your enthusiasm for the project and how your skills align with their goals. We love seeing genuine interest!
✨Tip Number 3
Prepare for technical questions! Brush up on your knowledge about adenosine receptors and pain mechanisms. Being able to discuss these topics confidently will show that you're ready to dive into the research right away.
✨Tip Number 4
Apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, it shows you’re serious about joining our team at the University of Warwick.
We think you need these skills to ace Postdoctoral Research Fellow in Pain Research in Coventry
Some tips for your application 🫡
Tailor Your Application: Make sure to customise your application to highlight how your skills and experiences align with the specific requirements of the Postdoctoral Research Fellow position. We want to see how you can contribute to our exciting research on BnOCPA!
Showcase Your Research Experience: Don’t hold back on detailing your previous research projects, especially those related to pain mechanisms or neuroscience. We love seeing how your background fits into our work at the University of Warwick.
Be Clear and Concise: Keep your application clear and to the point. We appreciate well-structured applications that make it easy for us to see your qualifications and enthusiasm for the role.
Apply Through Our Website: Remember to submit your application through our official website. It’s the best way for us to receive your details and ensures you’re considered for this fantastic opportunity in our team!
How to prepare for a job interview at University of Warwick
✨Know Your Research Inside Out
Make sure you’re well-versed in the specifics of the painkilling mechanism involving BnOCPA. Be prepared to discuss its implications, how it interacts with the adenosine A1 receptor, and the significance of the Gob subunit. This shows your genuine interest and expertise in the project.
✨Familiarise Yourself with the Labs
Research the three labs involved in the project: Frenguelli, Wall, and Zhang. Understand their specific expertise and how they contribute to the research. This will help you articulate how you can fit into their collaborative environment and what unique skills you bring to the table.
✨Prepare for Technical Questions
Expect questions related to molecular and cellular mechanisms, as well as experimental techniques relevant to neuropathic and inflammatory pain models. Brush up on your knowledge of in silico methods and synaptic transmission to demonstrate your technical proficiency.
✨Show Enthusiasm for Interdisciplinary Work
Highlight your excitement about working in a diverse team of neuroscientists. Discuss any previous experiences you have had in interdisciplinary settings and how you can contribute to the collaborative nature of the project at the University of Warwick.
