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- Tasks: Join a team to model ALS using iPSCs and analyse transcriptomic changes.
- Company: Nuffield Department of Medicine, a leader in innovative medical research.
- Benefits: Full-time position with a 2-year contract, contributing to impactful research.
- Why this job: Make a difference in understanding ALS and contribute to groundbreaking discoveries.
- Qualifications: MSc in relevant fields and experience with neurodegenerative diseases and iPSC culture.
- Other info: Collaborative environment with opportunities for professional growth and development.
The predicted salary is between 30000 - 50000 ÂŁ per year.
We are seeking to appoint a Research Assistant to join the Nuffield Department of Medicine to work on modelling Amyotrophic Lateral Sclerosis (ALS) using induced pluripotent stem cells (iPSCs) and transcriptomic analysis of derived neurons. The project investigates transcriptomic changes linked to early stages of Motor Neuron Disease (MND) and ALS, focusing on the misregulation of TDP-43 and associated RNA processing defects. The work aims to identify and validate transcriptomic changes, potential drug targets and biomarkers, and to develop and optimize neuronal models to characterise disease mechanisms.
Responsibilities
- Culture and characterise iPSC-derived neuronal models and generate novel cell lines using CRISPRâCas9 genome editing.
- Utilise mRNAâ and iCLIPâsequencing approaches to analyse RNA expression and regulation changes.
- Undertake cellular and biochemical assays using advanced cell and molecular biology and imaging techniques.
- Conduct a small molecule screen in collaboration with the Oxford Drug Discovery Institute.
- Design, test and optimise antisense oligonucleotides to alter RNA processing defects.
- Contribute to data analysis and interpretation with support from bioinformatics and imaging teams.
- Assist in scientific reports, publications and presentations.
- Adapt and develop experimental protocols, contribute to laboratory management and collaborative projects, and comply with health and safety regulations.
Qualifications
- MSc degree in Neuroscience, Biology, Molecular Biology, Biochemistry, Biomedical Sciences, Genetics/Genomics or a related area.
- Experience and knowledge of neurodegenerative diseases such as ALS.
- Experience in iPSCâderived neuron culture and sterile technique.
- Prior knowledge of conducting small molecule screens.
- Experience in molecular biology techniques including cloning, RTâPCR, immunoblotting, immunofluorescence and microscopy.
- Highly motivated, able to interpret and optimise experimental work, work collaboratively across teams, and demonstrate excellent communication skills including presenting research results in laboratory and external meetings.
Application Information
Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.
Contract and Funding
This position is offered full time on a fixed term contract for 2 years and is funded by the MND Association.
Deadline
Only applications received before 12 midday on 31 March 2026 will be considered.
Research Assistant - Modelling ALS in iPSCs and transcriptomics of derived neurons employer: University of Oxford
Contact Detail:
University of Oxford Recruiting Team
StudySmarter Expert Advice đ¤Ť
We think this is how you could land Research Assistant - Modelling ALS in iPSCs and transcriptomics of derived neurons
â¨Tip Number 1
Network like a pro! Reach out to people in the field of neuroscience and ALS research. Attend seminars, webinars, or local meetups to connect with potential colleagues and mentors. You never know who might have a lead on a job or can give you insider tips!
â¨Tip Number 2
Show off your skills! When you get the chance for an interview, be ready to discuss your experience with iPSC culture and molecular biology techniques. Bring examples of your work or even a portfolio if you can. This will help us see how you can contribute to our team.
â¨Tip Number 3
Donât just apply anywhere; focus on roles that excite you! Check out our website for openings that match your skills and interests. Tailor your application to highlight how your background in neurodegenerative diseases makes you a perfect fit for the Research Assistant role.
â¨Tip Number 4
Follow up after interviews! A quick thank-you email can go a long way. It shows your enthusiasm for the position and keeps you fresh in the interviewer's mind. Plus, itâs a great opportunity to reiterate why youâre the best candidate for the job!
We think you need these skills to ace Research Assistant - Modelling ALS in iPSCs and transcriptomics of derived neurons
Some tips for your application đŤĄ
Craft a Compelling Supporting Statement: Your supporting statement is your chance to shine! Make sure you clearly explain how your skills and experiences align with the selection criteria. Use specific examples to show us what you can bring to the table.
Tailor Your CV: Donât just send a generic CV! Tailor it to highlight your relevant experience in neurodegenerative diseases, iPSC culture, and molecular biology techniques. We want to see how your background fits perfectly with our research goals.
Be Clear and Concise: Keep your application clear and to the point. Avoid jargon and make sure your writing is easy to understand. We appreciate straightforward communication, so letâs keep it simple!
Apply Through Our Website: Remember to apply through our website! Itâs the best way to ensure your application gets to us. Plus, youâll find all the details you need right there, making the process smoother for you.
How to prepare for a job interview at University of Oxford
â¨Know Your Science
Make sure you brush up on the latest research related to ALS and iPSCs. Being able to discuss recent findings or breakthroughs will show your passion and knowledge in the field, which is crucial for a role like this.
â¨Prepare Your Examples
Think of specific instances where you've used techniques like CRISPR-Cas9 or conducted small molecule screens. Be ready to explain your thought process and the outcomes, as this will demonstrate your hands-on experience and problem-solving skills.
â¨Show Your Team Spirit
This role involves collaboration across various teams, so be prepared to talk about your experiences working in a team setting. Highlight how youâve contributed to group projects and how you handle feedback and communication.
â¨Tailor Your Supporting Statement
When writing your supporting statement, directly address each selection criterion mentioned in the job description. Use clear examples from your past experiences that align with the responsibilities of the role to make a strong case for yourself.