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- Tasks: Join a cutting-edge research team to study neuronal cell biology and Parkinson's disease.
- Company: University of Oxford's Department of Physiology, Anatomy & Genetics - a hub for innovative science.
- Benefits: Enjoy 38 days annual leave, excellent pension, and childcare services.
- Why this job: Make a real impact in neurodegenerative research while collaborating with top scientists.
- Qualifications: BSc or MSc in neuroscience or cell biology; experience in stem cell culture is a plus.
- Other info: Inclusive environment promoting diversity and sustainability in research.
The predicted salary is between 30000 - 42000 £ per year.
Department of Physiology, Anatomy & Genetics, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU
Contract & job type: Full-time, Fixed-term for 24 months
About us: At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment.
Overview of the role: We are seeking a Research Assistant to join our Laboratory of Molecular Neurodegeneration within the Department of Physiology, Anatomy and Genetics at the University of Oxford. The ideal candidate will be a motivated and skilled cell biologist with experience in stem cell culture, neuronal differentiation, and phenotypic assays. A strong background in neurobiology, cell imaging, and molecular techniques, along with excellent organizational and collaborative skills, is essential. In this role, you will be responsible for supporting a collaborative research project between the University of Oxford and Neumora, funded by the Michael J. Fox Foundation. You will perform neuronal differentiation and phenotypic testing in human induced pluripotent stem cell (iPSC)-derived dopamine neurons to evaluate novel therapeutics targeting lysosomal function in Parkinson’s disease. You will work within the state-of-the-art Neuronal Phenotyping and Stem Cell Facility and contribute to translational research at the interface of academic science and pharmaceutical drug discovery. This post is available for 24 months.
Key responsibilities:
- Apply cellular, molecular and metabolomic assay techniques in iPSC-derived neurons from patients to test novel modulators of lysosome function
- Study the effect of novel modulators of lysosome function across cell and organelle biology in iPSC-derived neuronal models of Parkinson’s
- Undertake maintenance culture and neuronal differentiation of iPSC lines and differentiation into dopamine neurons
- Contribute to wider project planning, including ideas for new research projects
- Determine the most appropriate methodologies to test hypotheses, and identify suitable alternatives if technical problems arise
- Select, follow, and adapt experimental protocols
- Gather, analyse, and present scientific data from a variety of sources
- Contribute to scientific reports and journal articles and the presentation of data/papers at conferences
- Manage own research and administrative activities, within guidelines provided by senior colleagues
- Collaborate effectively with other team members to achieve collective goals
Selection criteria:
- Hold or be near to completion of BSc or MSc degree in neuroscience or cell/molecular biology or equivalent.
- Have experience in neuronal/glial cell culture, preferably in human pluripotent stem cells
- Have experience in setting up cellular assays, including image-based experiments
- Have knowledge of neurodegenerative diseases, such as Parkinson’s
- Be highly motivated, with the capacity to think creatively and work across teams
- Show commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work.
What we offer:
- An excellent contributory pension scheme
- 38 days annual leave
- A comprehensive range of childcare services
- Family leave schemes
- Cycle and electric car loan schemes
- Employee Assistance Programme
- Membership to a variety of social and sports clubs
- Discounted bus travel and Season Ticket travel loans
How to apply: Please provide a supporting statement outlining how you meet the selection criteria along with your CV, and the details of two referees as part of your online application. The closing date for applications is 12 noon on Friday 5th December. Interviews are likely to take place during the week commencing 15th December, and will be either face to face or held on Microsoft Teams. Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.
Informal enquiries about the role may be directed to the DPAG HR Team: hr@dpag.ox.ac.uk
DPAG’s Statement of Inclusion: We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. Our policies, practices and Respectful Behaviours Framework underpin this commitment.
DPAG and Sustainability: We have signed up to The Laboratory Efficiency Assessment Framework (LEAF) and Green Impact, actively implementing and encouraging eco-friendly practices that reduce waste, promote energy efficiency, and promote bio-diversity.
Research Assistant – Neuronal cell biologist in restoring lysosomal function in Parkinson’s disease in Oxford employer: University of Oxford
Contact Detail:
University of Oxford Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Research Assistant – Neuronal cell biologist in restoring lysosomal function in Parkinson’s disease in Oxford
✨Tip Number 1
Network like a pro! Reach out to current or former employees at the University of Oxford or Neumora. A friendly chat can give you insider info and maybe even a referral, which can really boost your chances.
✨Tip Number 2
Prepare for the interview by brushing up on your knowledge of neurodegenerative diseases, especially Parkinson’s. Show us that you’re not just passionate but also well-informed about the field and the specific role.
✨Tip Number 3
Practice your presentation skills! You might need to present scientific data or ideas during the interview. Make sure you can communicate your thoughts clearly and confidently, as collaboration is key in our lab.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen. Plus, it shows us you’re serious about joining our team at DPAG.
We think you need these skills to ace Research Assistant – Neuronal cell biologist in restoring lysosomal function in Parkinson’s disease in Oxford
Some tips for your application 🫡
Craft a Compelling Supporting Statement: Your supporting statement is your chance to shine! Make sure to clearly outline how your skills and experiences align with the selection criteria. Be specific about your background in neuronal cell biology and any relevant techniques you've mastered.
Tailor Your CV: Don’t just send a generic CV! Tailor it to highlight your experience in stem cell culture, neuronal differentiation, and any other relevant skills. We want to see how you fit into our team and the exciting work we do.
Show Your Passion for Research: In your application, let us know why you're passionate about neurobiology and how you can contribute to our research on Parkinson’s disease. A little enthusiasm goes a long way in making your application stand out!
Apply Through Our Website: Make sure to submit your application through our website. It’s the easiest way for us to keep track of your application and ensures you’re considered for this fantastic opportunity at DPAG!
How to prepare for a job interview at University of Oxford
✨Know Your Science
Make sure you brush up on your knowledge of neurobiology and lysosomal function, especially in relation to Parkinson’s disease. Be prepared to discuss your experience with iPSC-derived neurons and any relevant techniques you've used in your previous research.
✨Showcase Your Skills
Highlight your hands-on experience with stem cell culture and neuronal differentiation during the interview. Bring examples of your past work, such as data from cellular assays or imaging experiments, to demonstrate your capabilities and how they align with the role.
✨Collaborative Spirit
Since this role involves working closely with a team, be ready to talk about your collaborative experiences. Share specific examples of how you've contributed to group projects and how you handle challenges when working with others.
✨Engage with Inclusion
Familiarise yourself with the department's commitment to equality, diversity, and inclusion. Be prepared to discuss how you can contribute to creating an inclusive environment and why it matters in scientific research.