The project will investigate the contribution of solute transport mechanisms, with particular emphasis on the TMEM16A anion channel, to the regulation of cardiac pericyte function. The work builds on collaborative studies and will benefit from complementary clinical research, as well as access to specialist expertise and clinical samples through collaborations with Cardiology at the John Radcliffe Hospital in Oxford.
The principal objective of the project is to investigate the mechanisms controlling cardiac pericyte tone under normal and ischaemic conditions. In particular, the project aims to identify and characterise ion channels and associated signalling mechanisms that could represent novel therapeutic targets for complications of cardiac ischaemia, including the coronary no-reflow phenomenon.
You will be expected to manage your own academic research and administrative activities, adapt existing and develop new scientific techniques and experimental protocols, and test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. The role will also involve contributing ideas for new research projects and for generating research income, and collaborating in the preparation and presentation of scientific reports and journal articles.
You must hold a relevant PhD/DPhil (or be close to completion), together with relevant experience and should also have proven experience in electrophysiology (patch-clamp) and/or ion imaging in heterologous expression systems and/or native cells (eg vascular) and/or live or immunostaining imaging of microvasculature in isolated tissue preparations. Knowledge of ion channel pharmacology and molecular physiology and/or vascular physiology and pharmacology is essential as is previous experience of contributing to publications/presentations and excellent communication skills.
The post is available from 1 January 2027 on a fixed-term basis for two years, funded by the British Heart Foundation.
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Postdoctoral Research Assistant in Vascular Ion Channel Pathways in Oxford employer: University of Oxford
The Department of Politics and International Relations at the University of Oxford is an exceptional employer, offering a collaborative and intellectually stimulating environment where finance professionals can thrive. With a commitment to equality, diversity, and inclusion, along with generous benefits such as 38 days of annual leave and a robust family leave scheme, employees are supported in both their professional and personal lives. This role not only provides the opportunity to influence strategic financial decisions within a world-renowned department but also fosters continuous growth and development in a vibrant academic community.
