At a Glance
- Tasks: Conduct groundbreaking research in cardiovascular pharmacology and explore drug effects on heart function.
- Company: Join a leading research team supported by the British Heart Foundation.
- Benefits: Gain valuable experience, access to cutting-edge technology, and contribute to impactful research.
- Other info: Collaborative environment with opportunities for innovative research and professional growth.
- Why this job: Make a difference in cardiac health while advancing your scientific career.
- Qualifications: PhD/DPhil in relevant field with hands-on experience in cardiovascular pharmacology.
The predicted salary is between 35000 - 45000 £ per year.
We are seeking a Postdoctoral Researcher to carry out research in cardiovascular pharmacology as part of a project supported by the British Heart Foundation, working in the group of Dr Charalampos Sigalas in the Department of Pharmacology. The aim of the post is to characterise the molecular and cellular effects induced by mutations in the cardiac Ryanodine Receptor (RyR2) which are linked to an inherited lethal cardiac disease called Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT). The project also aims to investigate the effects of selected drugs on RyR2 channel function and Ca2+-release from the sarcoplasmic reticulum of cardiac myocytes.
The successful candidate will conduct experiments using single-channel recordings of RyR2 reconstituted in artificial lipid bilayers. They will also perform Ca2+-imaging experiments in cardiac myocytes isolated from mouse hearts. You will manage your own academic research and administrative activities, adapting existing and developing new scientific techniques and experimental protocols, testing hypotheses and analysing scientific data from a variety of sources and will contribute ideas for new research projects.
The postholder will be expected to use specialist scientific equipment in a laboratory environment and perform experiments using the following techniques:
- Isolation of sarcoplasmic reticulum vesicles from cardiac muscle
- Isolation of cardiac myocytes from mouse hearts using the Langendorff perfused heart preparation
- Single-channel reconstitution in artificial lipid bilayers
- Ca2+-imaging experiments in isolated cardiac myocytes
You must have a relevant PhD/DPhil (or be close to completion), together with relevant experience in cardiovascular pharmacology. Sufficient experience in isolating sarcoplasmic reticulum vesicles and cardiac myocytes from rodent cardiac muscle; performing experiments using single-channel reconstitution in artificial lipid bilayers, and Ca2+-imaging in cardiac myocytes; and management of rodent colonies are all essential.
Postdoctoral Research Assistant in Cardiovascular Pharmacology in Oxford employer: University of Oxford
Join a leading research team at the forefront of cardiovascular pharmacology, where you will have the opportunity to contribute to groundbreaking studies supported by the British Heart Foundation. Our collaborative work culture fosters innovation and personal growth, providing you with access to state-of-the-art facilities and resources in a vibrant academic environment. With a focus on professional development, we encourage our researchers to explore new ideas and advance their careers while making a meaningful impact in the field of cardiac health.
StudySmarter Expert Advice🤫
We think this is how you could land Postdoctoral Research Assistant in Cardiovascular Pharmacology in Oxford
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We think you need these skills to ace Postdoctoral Research Assistant in Cardiovascular Pharmacology in Oxford
Some tips for your application 🫡
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