At a Glance
- Tasks: Explore cutting-edge DNA polymerases for biotechnology and develop innovative solutions.
- Company: Join the University of Nottingham and Nottingham Trent in a collaborative research environment.
- Benefits: Fully funded PhD studentship with access to world-class training and resources.
- Other info: Embrace diversity and inclusion in a supportive research community.
- Why this job: Make a real impact in sustainable biotechnology while advancing your scientific career.
- Qualifications: Ideal for graduates in Bioscience, Biochemistry, or related fields with strong academic backgrounds.
The predicted salary is between 18000 - 25000 € per year.
About the Project
Thanks to £14m of funding awarded by the Biotechnology and Biological Sciences Research Council (BBSRC), the University of Nottingham and Nottingham Trent in partnership with the National Biofilms Innovation Centre (NBIC) are offering fully funded innovative four-year cohort-based training in frontier science.
We invite applications for a BBSRC fully funded CASE studentship to investigate (NE)B‑Family DNA polymerases for Biotechnology. This sits under our Biotechnology for Sustainable Growth theme and is offered through partnership with New England Biolabs.
Archaeal family B DNA polymerases are a cornerstone of biotechnology. Enzymes such as Vent, Deep Vent, Phusion, and Q5 are family B DNA polymerases (PolB) that originate from Archaea – they have been developed by New England Biolabs (NEB) for PCR amplification and next‑generation DNA sequencing applications. Such enzymes require robust strand displacement activities, which are found in PolB but not in PolD, the D‑family DNA polymerase exclusive to Archaea.
The goal of the PhD project is to develop a new class of DNA polymerase for biotechnology, while providing functional insights into the assembly of the archaeal DNA replication machinery and the unique mechanisms of DNA replication in Archaea.
Why choose this project?
The lab of Thorsten Allers works on DNA replication, recombination, and repair in Archaea. We use Haloferax volcanii as a model for archaeal genetics – this species is easy to grow and has a wide range of genetic tools, most of which have been developed in our lab. H. volcanii is ideal to investigate the rules of life and to develop new tools for biotechnology.
In the initial phase of the project, the student will acquire experimental skills in microbial genetics, molecular biology, and bioinformatics. The project will involve the generation of plasmids and strains to carry out genetic screens of H. volcanii PolB and PolD variants. Strains with polymerase variants will be tested for the efficiency and accuracy of DNA synthesis in vivo, using microbiological techniques including growth competition and mutation accumulation assays, microscopy and flow cytometry, pulsed‑field gel electrophoresis, and genomic technologies including nanopore DNA sequencing.
Collaborating Partner
New England Biolabs (NEB) is a world‑renowned biotechnology company that makes and supplies enzymes, reagents, and tools used in molecular biology and genetic research.
Requirements
Applications are invited from candidates with backgrounds in Bioscience, Biochemistry, Microbiology, Biotechnology, Chemistry, Chemical/Biochemical/Process Engineering, Environmental Science, Pharmacy, Computer Science, Maths or related disciplines who have/expect to graduate with a first/upper‑second UK honours degree, or equivalent qualifications gained outside the UK. Applications are also welcome from candidates with a 2:2 undergraduate degree or lower, who hold a Masters degree in a relevant area or three or more years of full‑time work experience relevant to the undergraduate degree, or to the PhD projects you are applying for. This project is open only to those with home fee status.
Equality, Diversity and Inclusion
The Nottingham BBSRC DLA is committed to equality, diversity and inclusion in its recruitment practices and throughout the delivery of our PhD programme. For 2026 recruitment, we are operating a Guaranteed Interview Scheme for applicants from Black and Black mixed backgrounds who hold home fee status.
PhD Studentship: BBSRC – DLA PhD Studentship: (NE)B-Family DNA polymerases for Biotechnology in Nottingham employer: University Of Nottingham
The University of Nottingham and Nottingham Trent, in collaboration with the National Biofilms Innovation Centre, offer an exceptional environment for PhD students, providing fully funded training in cutting-edge biotechnology research. With a strong emphasis on equality, diversity, and inclusion, students benefit from a supportive work culture that fosters innovation and collaboration, alongside opportunities for personal and professional growth in a vibrant academic setting.
StudySmarter Expert Advice🤫
We think this is how you could land PhD Studentship: BBSRC – DLA PhD Studentship: (NE)B-Family DNA polymerases for Biotechnology in Nottingham
✨Tip Number 1
Network like a pro! Reach out to current PhD students or faculty members in your field. They can provide insights about the application process and might even give you a heads-up on opportunities before they’re advertised.
✨Tip Number 2
Prepare for interviews by practising common questions related to your research interests. We recommend doing mock interviews with friends or mentors to build confidence and refine your answers.
✨Tip Number 3
Showcase your passion for the project! When discussing your interest in the (NE)B-Family DNA polymerases, highlight any relevant experience or projects that align with the research goals. This will make you stand out!
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets the attention it deserves. Plus, we love seeing candidates who are proactive about their applications.
We think you need these skills to ace PhD Studentship: BBSRC – DLA PhD Studentship: (NE)B-Family DNA polymerases for Biotechnology in Nottingham
Some tips for your application 🫡
Tailor Your Application:Make sure to customise your application to highlight how your background and skills align with the project. We want to see your passion for biosciences and how you can contribute to our research on (NE)B-Family DNA polymerases.
Showcase Relevant Experience:Don’t forget to include any relevant experience, whether it’s academic or practical. If you've worked with microbial genetics or molecular biology, let us know! This will help us see how you fit into the team.
Be Clear and Concise:Keep your writing clear and to the point. We appreciate well-structured applications that are easy to read. Avoid jargon unless it's necessary, and make sure your enthusiasm shines through!
Apply Through Our Website:Remember to submit your application through our official website. It’s the best way to ensure we receive all your details correctly and can process your application smoothly.
How to prepare for a job interview at University Of Nottingham
✨Know Your Science
Make sure you brush up on the key concepts related to (NE)B-Family DNA polymerases and their applications in biotechnology. Familiarise yourself with the specific enzymes mentioned, like Vent and Phusion, and understand their roles in PCR and DNA sequencing.
✨Showcase Your Skills
Prepare to discuss your experimental skills in microbial genetics, molecular biology, and bioinformatics. Be ready to share any relevant projects or experiences that demonstrate your ability to generate plasmids, conduct genetic screens, or use genomic technologies.
✨Ask Insightful Questions
Think of thoughtful questions to ask about the project and the lab environment. Inquire about the specific techniques used in the lab, the collaborative nature of the research, or how the team approaches challenges in their work. This shows your genuine interest and engagement.
✨Emphasise Teamwork and Collaboration
Highlight your ability to work in a team, especially in a research setting. Discuss any past experiences where you collaborated with others on scientific projects, as this is crucial for success in a cohort-based training programme.
