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- Tasks: Explore Umami receptors using advanced NMR techniques and study small molecule interactions.
- Company: Join UEA's School of Chemistry, collaborating with PepsiCo on innovative food science research.
- Benefits: Gain hands-on experience, develop transferrable skills, and enjoy a placement at PepsiCo.
- Why this job: Dive into cutting-edge research with real-world impact on food taste and health.
- Qualifications: A 2:1 (Hons) in Chemistry, Pharmacy, Pharmacology or related field is required.
- Other info: This is a four-year funded PhD studentship starting on 1 October 2025.
The predicted salary is between 20000 - 30000 £ per year.
Primary supervisor – Dr Matthew Wallace This four-year funded PhD studentship is available in the School of Chemistry, Pharmacy and Pharmacology atUEA, in collaboration with PepsiCo as part of the BBSRC Food Consortium Collaborative Training Partnership. Umami or ‘savory’ is one of the five basic food tastes, the others being salty, sweet, bitter and sour. Monosodium glutamate is the prototypical compound known to elicit the umami taste in humans. However, a desire to lower the sodium content of foods coupled with adverse consumer perceptions of this compound has led to the search for alternatives. Short peptides, typically 2-4 amino acids long, have emerged as a promising new class of compounds along with oligonucleotides (1). However, the incredible chemical diversity available (>230,000 tetrapeptides possible from the 22 natural amino acids alone, with further synthetic modifications possible) means that it is imperative that we can predict and study in vitro which compounds are likely to be effective Umami additives to avoid the synthesis and human testing of ineffective compounds. Key to the Umami taste are the protein receptors T1R1/T1R3 to which a compound must bind to elicit a response. However, as membrane-bound proteins, these receptors are extremely challenging to study using conventional analytical approaches. In this project, you will apply cutting-edge nuclear magnetic resonance (NMR) techniques developed at UEA to study the interaction of small molecules with Umami receptors overexpressed directly on the surface of live cells (2). You will thus establish ‘rules’ determining which molecular features enhance binding to the receptors. This information will be carried forward to human tasting panels. You will also investigate how other components of food matrices inhibit binding. You will thus develop a strong and transferrable skillset in cell culture/protein expression, NMR spectroscopy, data analysis and food science. You will also have the opportunity to undertake a placement at PepsiCo. Entry requirements The standard minimum entry requirement is 2:1 (Hons) in Chemistry, Pharmacy, Pharmacology or a related discipline. Mode of study Full-time Start date 1 October 2025 #J-18808-Ljbffr
Probing the activity of Umami receptors using on-cell nuclear magnetic resonance (WALLACEM_U25S[...] employer: University of East Anglia
Contact Detail:
University of East Anglia Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Probing the activity of Umami receptors using on-cell nuclear magnetic resonance (WALLACEM_U25S[...]
✨Tip Number 1
Familiarise yourself with the latest research on Umami receptors and their role in food science. This will not only help you understand the project better but also allow you to engage in informed discussions during interviews.
✨Tip Number 2
Network with professionals in the field of chemistry and food science, especially those who have experience with NMR techniques. Attend relevant conferences or seminars to make connections that could support your application.
✨Tip Number 3
Gain practical experience in cell culture and protein expression, as these skills are crucial for the role. Consider volunteering in a lab or taking short courses to enhance your hands-on expertise.
✨Tip Number 4
Prepare thoughtful questions about the project and its implications for the food industry. Showing genuine interest and curiosity can set you apart during the interview process.
We think you need these skills to ace Probing the activity of Umami receptors using on-cell nuclear magnetic resonance (WALLACEM_U25S[...]
Some tips for your application 🫡
Understand the Project: Read the job description thoroughly to grasp the specifics of the PhD project. Familiarise yourself with the concepts of Umami receptors, NMR techniques, and the relevance of the research in food science.
Tailor Your CV: Highlight your academic achievements, particularly in Chemistry, Pharmacy, or Pharmacology. Include any relevant research experience, skills in NMR spectroscopy, or cell culture that align with the project requirements.
Craft a Compelling Cover Letter: Write a cover letter that expresses your passion for the subject matter. Discuss why you are interested in this specific PhD opportunity and how your background makes you a suitable candidate for the role.
Proofread Your Application: Before submitting, carefully proofread your CV and cover letter for any errors. Ensure that your application is clear, concise, and free from typos to make a strong impression.
How to prepare for a job interview at University of East Anglia
✨Know Your Science
Make sure you have a solid understanding of the chemistry and pharmacology concepts related to Umami receptors. Be prepared to discuss how your academic background aligns with the project, especially regarding NMR techniques and protein interactions.
✨Show Enthusiasm for Food Science
Express your passion for food science and the importance of Umami in culinary applications. Discuss any relevant projects or experiences that demonstrate your interest in this area, particularly those involving food additives or sensory analysis.
✨Prepare Questions for Your Interviewers
Have insightful questions ready for Dr Matthew Wallace and the team at PepsiCo. This shows your genuine interest in the project and helps you understand their expectations and the collaborative nature of the studentship.
✨Highlight Transferable Skills
Emphasise any skills that are transferable to this role, such as data analysis, cell culture, or experience with spectroscopy. Be specific about how these skills will help you succeed in the research environment and contribute to the project.
