At a Glance
- Tasks: Investigate P2X receptors in cancer cells and develop new pharmacological tools.
- Company: Join a leading research team at UEA under Dr Leanne Stokes.
- Benefits: Receive a competitive stipend, tuition coverage, and gain valuable research skills.
- Other info: Full-time PhD studentship starting October 2027 with excellent career development opportunities.
- Why this job: Make a real impact in cancer research and contribute to innovative therapies.
- Qualifications: Must have a 2:1 degree in Pharmacology, Biomedicine, or related fields.
The predicted salary is between 21805 - 21805 £ per year.
About the Project
Primary Supervisor - Dr Leanne Stokes
There is a growing literature documenting the exploitation of ion channels by cancer cells. P2X receptors are ligand-gated ion channels (P2X1-7) activated by the extracellular signalling molecule ATP. Concentrations of ATP are known to be high within tumour microenvironments potentially driving cellular adaptations and exploiting downstream signalling associated with P2X receptors.
This project will undertake two main lines of investigation; i) to characterise the expression of important P2X receptors and their variants within cancer cells under different conditions, and ii) to determine the benefit of blocking various P2X receptors (either individually or through dual antagonism) to cancer cell growth and survival.
Aberrant splicing events are common within cancer and novel splice isoforms have the potential to be neo-antigens (e.g. targets for immunotherapy or markers for diagnostic/prognostic purposes). At least 18 splice variants of P2X7 have been described but very little is known about their expression levels and functionality. Nothing is known about P2X4 variants as yet. We will explore RNAseq data from public databases and together with quantitative PCR data, we will assemble this information.
Our recent work has discovered compounds that can act as dual antagonists of P2X7 and P2X4 receptors and we will compare their efficacy to individual blockade of either P2X7 or P2X4.
The aims of the project are to:
- characterise splice variant expression of P2X7 and P2X4 receptors across a range of cancer cell lines and conditions,
- generate P2X7 and P2X4-null cancer cells using CRISPR/Cas9 gene editing to further understand how these ion channels contribute to cancer cell biology, and
- test dual antagonists of P2X7/P2X4 in in vitro cancer cell survival and growth assays.
Skills developed: cell culture, molecular biology, gene editing and pharmacology plus transferable skills. This project would suit a graduate from Biomedical Science or Pharmacology.
Entry Requirements
The standard minimum entry requirement is 2:1 in Pharmacology, MPharm, Biomedicine, Biomedical Science, Biological Sciences.
Mode of Study: Full-time
Start Date: 1 October 2027
Additional Funding Information: This PhD project is in a competition for a Faculty of Science funded studentship. Funding is available to UK applicants and comprises ‘home’ tuition fees and an annual stipend for 3 years. The current UEA / institutional PhD stipend rate is £21,805 and will be subject to any agreed inflationary uplift for 2027/28.
PhD Studentship: New pharmacological tools for targeting P2X receptors in cancer in Norwich employer: University of East Anglia
The University of East Anglia (UEA) is an exceptional employer, offering a supportive work culture that prioritises employee growth and development. As a Commercialisation Administrator, you will benefit from a generous benefits package, including 34 days of annual leave, and the opportunity to contribute to meaningful projects that impact society and the economy. UEA's commitment to gender equality, recognised by its Athena Swan Silver Institutional Award, further enhances its reputation as a progressive workplace.
StudySmarter Expert Advice🤫
We think this is how you could land PhD Studentship: New pharmacological tools for targeting P2X receptors in cancer in Norwich
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We think you need these skills to ace PhD Studentship: New pharmacological tools for targeting P2X receptors in cancer in Norwich
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How to prepare for a job interview at University of East Anglia
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