At a Glance
- Tasks: Explore how snRNA modifications regulate RNA splicing using cutting-edge techniques.
- Company: Join a prestigious RNA (epi)genetics laboratory led by Dr Alper Akay.
- Benefits: Generous stipend, mentorship, and opportunities to attend conferences and seminars.
- Other info: Collaborative environment with access to national and international labs.
- Why this job: Make impactful discoveries in RNA biology and contribute to groundbreaking research.
- Qualifications: 2:1 in Biological sciences, molecular biology, or biochemistry required.
The predicted salary is between 93 - 93 £ per hour.
How do snRNA modifications regulate RNA splicing? Our RNA (epi)genetics laboratory addresses this broad question using the nematode Caenorhabditis elegans as an animal model. RNA is at the centre of many gene regulatory processes. There are currently more than 150 distinct chemical modifications on RNA, and a greater number of proteins are required for their synthesis and recognition. Recent discoveries have shown that RNA modifications can be dynamically regulated, and they have been implicated in embryonic development, longevity, neurological diseases and cancers in humans and in animal models.
The PhD project will focus on how spliceosomal snRNA modifications regulate RNA splicing. Our lab has shown that snRNA methylation can affect splice site choice during pre-mRNA splicing. The project will use molecular biology, genetics and RNA sequencing to investigate how gene-specific splice site choice influences transcript isoform expression in C. elegans and human cells. The project will be based in Dr Akay’s group and carried out in collaboration with the groups of Dr Wilfried Haerty and Dr James Smith.
We offer a multidisciplinary and supportive research environment. The student will receive extensive support to learn a range of techniques and will interact with national and international laboratories working on RNA modifications. The student will attend conferences, seminars and cross-laboratory events. The student will receive internal and external mentorship and career development support. Our RNA (epi)genetics laboratory is funded by a prestigious UKRI Future Leaders Fellowship and provides generous resources and instrumentation. This project is particularly suitable for students interested in RNA biology, biochemistry and RNA sequencing analysis.
Entry requirements: The standard minimum entry requirement is 2:1 in Biological sciences, molecular biology, biochemistry or relevant.
Mode of study: Full-time
Start date: 1 October 2027
Additional Funding Information: This PhD project is in a competition for a Faculty of Science funded studentship. Funding is available to UK applicants and comprises ‘home’ tuition fees and an annual stipend for 3 years. The current UEA / institutional PhD stipend rate is £21,805 and will be subject to any agreed inflationary uplift for 2027/28.
PhD Studentship: Alternative splicing regulation by snRNA modifications in Norwich employer: University of East Anglia
The University of East Anglia (UEA) is an exceptional employer, offering a supportive work culture that prioritises employee growth and development. As a Commercialisation Administrator, you will benefit from a generous benefits package, including 34 days of annual leave, and the opportunity to contribute to meaningful projects that impact society and the economy. UEA's commitment to gender equality, recognised by its Athena Swan Silver Institutional Award, further enhances its reputation as a progressive workplace.
StudySmarter Expert Advice🤫
We think this is how you could land PhD Studentship: Alternative splicing regulation by snRNA modifications in Norwich
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How to prepare for a job interview at University of East Anglia
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at University of East Anglia. You might even be asked to demonstrate your understanding of these processes.
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