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- Tasks: Join a pioneering research team to develop innovative drug discovery methods.
- Company: University of Dundee, a leading institution in life sciences research.
- Benefits: Competitive salary, collaborative environment, and access to cutting-edge technology.
- Why this job: Make a real impact on health by researching molecular glues for neurodegenerative diseases.
- Qualifications: Experience in structural or chemical biology and protein-ligand interactions.
- Other info: Dynamic, diverse workplace with excellent career growth opportunities in a beautiful setting.
The predicted salary is between 31000 - 38000 £ per year.
Overview
This is an outstanding opportunity to join a recently established Research Centre that is pioneering new models of translational chemical biology and advancing the frontiers of molecular glue research. You will gain experience in world-leading, collaborative, and high-impact research at the forefront of drug discovery, with access to strong academic and industrial partnerships. We are seeking a highly motivated Postdoctoral Researcher in Structural and/or Chemical Biology to join the research group of Dr Peter Cossar at the Centre for Targeted Protein Degradation (CeTPD), University of Dundee.
The Cossar Lab integrates molecular biophysics, structural biology, and organic synthesis to develop chemical tools that address key questions in proximity-induced drug discovery, with a focus on targeting intrinsically disordered protein complexes. This Royal Society-funded position focuses on identifying molecular glues that stabilise disease-relevant protein complexes involved in Motor Neuron Disease (MND) and Frontotemporal Dementia (FTD). The position is available from the 1st of October 2025, and for a fixed-term of 3 years. The appointment will be made on University\\\’s Grade 7 salary scale (£37,174- £45,413), dependent on experience.
Your priorities
- Development of recombinant and/or cellular assays to monitor complex assembly
- Development of Native Mass Spectrometry screening platform
- Conduct fragment-based drug screening campaigns (non-covalent and covalent)
- Biophysically and structurally characterize hit compound binding
- Collaborate with team members to advance these hits into lead compounds
Who we\\\’re looking for
- Familiarity with either one of the two techniques
- Protein mass spectrometry for chemical biology and biophysics (strong preference for native MS)
- protein-ligand structural biology (X-ray or cryo-EM) including structure-refinement tools (e.g., CCP4, PHENIX, Coot, DIALS, Cryo-Spark, Relion)
- Experienced with biophysical assay design and troubleshooting
- Experience with studying protein-ligand interactions and structure-based drug design
- Cloning and DNA construct design is a plus
- Experienced with bacterial, insect and/or human recombinant protein expression systems
For further information about this position please contact Dr Peter Cossar at p.cossar001@dundee.ac.uk. To find out more about Group/Unit/Team/School please visit CeTPD at the University of Dundee.
About the department and location
The Protein Degradation Centre is located in a beautiful setting overlooking the estuary of the River Tay, close to some of Scotland\\\’s most spectacular mountain scenery. It is embedded within the University of Dundee\\\’s School of Life Sciences, one of the premier research centres in the world recently assessed as the top UK University for Life Sciences research in the 2014 Research Excellence Framework (REF), and again in the most recent REF2021. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities. The University of Dundee main city-centre campus is at the heart of Dundee – an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology, that is developing into a major cultural hub. Just a short walk from the V&A Museum of Design Dundee, we\\\’re close to both the train and bus stations.
The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well as a full range of disability services, create an enjoyable and inclusive place to work.
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Postdoctoral Research Assistant - CeTPD - UOD1992 employer: University of Dundee
Contact Detail:
University of Dundee Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Postdoctoral Research Assistant - CeTPD - UOD1992
✨Tip Number 1
Network like a pro! Reach out to current or former employees at the University of Dundee, especially in the CeTPD. A friendly chat can give you insider info and maybe even a referral.
✨Tip Number 2
Prepare for your interview by diving deep into the research being done at the Cossar Lab. Show us that you’re not just familiar with the techniques but genuinely excited about contributing to the team’s goals.
✨Tip Number 3
Practice your pitch! Be ready to explain how your skills in structural and chemical biology align with the projects at CeTPD. We want to hear how you can make an impact right from the start.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, it shows you’re serious about joining our vibrant community.
We think you need these skills to ace Postdoctoral Research Assistant - CeTPD - UOD1992
Some tips for your application 🫡
Tailor Your Application: Make sure to customise your CV and cover letter for the Postdoctoral Research Assistant role. Highlight your relevant experience in structural and chemical biology, and don’t forget to mention any specific techniques you’re familiar with, like protein mass spectrometry or protein-ligand interactions.
Show Your Passion: Let us see your enthusiasm for the research area! In your cover letter, share why you’re excited about the work being done at the CeTPD and how your background aligns with our goals in drug discovery and molecular glue research.
Be Clear and Concise: When writing your application, keep it straightforward. Use clear language and avoid jargon unless necessary. We want to understand your qualifications and motivations without wading through unnecessary fluff!
Apply Through Our Website: Don’t forget to submit your application through our official website! It’s the best way to ensure your application gets to the right people. Plus, you’ll find all the details you need about the position there.
How to prepare for a job interview at University of Dundee
✨Know Your Research
Dive deep into the research being conducted at the Centre for Targeted Protein Degradation. Familiarise yourself with Dr Peter Cossar's work and the specific projects related to molecular glue research. This will not only show your genuine interest but also help you ask insightful questions during the interview.
✨Highlight Relevant Experience
Make sure to emphasise your familiarity with techniques like protein mass spectrometry and structural biology. Prepare specific examples of your past work that align with the job description, especially any experience with biophysical assay design or studying protein-ligand interactions.
✨Prepare for Technical Questions
Expect technical questions related to your expertise in structural and chemical biology. Brush up on key concepts and methodologies, and be ready to discuss how you've applied them in your previous roles. Practising with a peer can help you articulate your thoughts clearly.
✨Show Your Collaborative Spirit
The role involves collaboration with team members, so be prepared to discuss your teamwork experiences. Share examples of how you've successfully worked in a team setting, particularly in a research environment, and how you contributed to advancing projects together.
