At a Glance
- Tasks: Join a cutting-edge research team to develop innovative small molecules and characterise protein interactions.
- Company: University of Dundee's CeTPD, a leader in translational chemical biology and drug discovery.
- Benefits: Gain experience in world-class research with opportunities for collaboration and career growth.
- Other info: Collaborative environment with opportunities to present findings at international conferences.
- Why this job: Make a real impact in drug discovery while working with top scientists in an exciting field.
- Qualifications: Ph.D. in relevant fields with expertise in structural biology and biophysics.
The predicted salary is between 41760 - 51040 £ per year.
We are seeking an exceptional Structural Biologist / Molecular Biophysicist to join an interdisciplinary, cross-institutional research team dedicated to developing an innovative new class of small molecules termed Phosphatase Targeting Chimeras (PhosTACs). The appointed researcher will be based within the state-of-the-art laboratories of the University of Dundee's CeTPD and will focus on the structural and biophysical characterisation of protein-ligand interactions and protein-protein complexes relevant to the PhosTACs programme, to understand binding modes and structure-activity relationships (SAR) and guide the design of improved molecules.
This is a broader and more independent role than a standard support post: the successful candidate will be expected to take increasing ownership of structural enablement of newly identified small-molecule binders, to drive structure-guided design decisions and to help lead this workstream across the collaboration. This is a unique opportunity to gain experience in world-leading, collaborative and cutting-edge research in one of the hottest areas of modern translational chemical biology and drug discovery, within an academia-industry partnership with exciting prospects for the future.
Your priorities will include:
- Characterising the binding of small-molecule bifunctional PhosTACs and their binding components to their target phosphatase and phospho-proteins components, using a range of structural and biophysical techniques including but not limited to X-ray crystallography, cryo-EM, NMR spectroscopy, and in-solution biophysical methods such as SPR, ITC and fluorescence-based assays.
- Designing constructs and expressing and purifying proteins to enable compound evaluation.
- Executing and optimising binding assays in vitro to profile novel compounds.
- Driving structure-guided design of PhosTACs by determining structure-activity relationships (SAR) in vitro, and taking a leading role in translating these into design recommendations for the wider team.
- Developing team science, working with colleagues across disciplines and institutions to enable breakthroughs.
- Presenting findings to the collaboration team and externally at international conferences.
Who we're looking for:
- A Ph.D. in structural biology, biophysics, biochemistry, chemical/molecular biology or a related discipline.
- Highly experienced in structural biology and biophysics, with an emphasis on structure-based drug design.
- Strong background in protein structure determination by X-ray crystallography, cryo-EM and/or NMR spectroscopy.
- Experience with biophysical techniques and assays to study protein-ligand binding and protein-protein interactions is strongly desired.
- Strong interpersonal, time management and communication skills.
- An open and collaborative approach to science.
- Capable of working in a diverse, cross-institutional team, but able to plan and work independently.
For further information about this position please contact Professor Alessio Ciulli.
Postdoctoral Scientist in Dundee employer: University of Dundee
The University of Dundee is an exceptional employer, offering a vibrant and collaborative academic environment where innovation thrives. As a Senior Computational Chemist, you will have access to cutting-edge resources and the opportunity to contribute to meaningful drug discovery projects, all while benefiting from professional growth and development within a supportive team. Located in a city known for its rich cultural heritage and commitment to research excellence, this role promises not only career advancement but also a fulfilling work-life balance.
StudySmarter Expert Advice🤫
We think this is how you could land Postdoctoral Scientist in Dundee
✨Get Involved in Local Research Communities
Tap into local biotechnology meetups and research forums. These are great places to mingle with industry professionals, share your passion, and even discover unadvertised job openings. It's all about getting your face known in the field!
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Biotech is a fast-paced field, so keeping yourself updated with the latest advancements is crucial. Attend industry conferences, webinars, or workshops to broaden your knowledge and meet potential employers. Plus, it’ll give you fantastic talking points for your interviews at places like University of Dundee!
We think you need these skills to ace Postdoctoral Scientist in Dundee
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show University of Dundee that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at University of Dundee.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that University of Dundee does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at University of Dundee
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at University of Dundee. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
✨Show Your Teamwork Skills
Biotech often involves collaboration across multiple disciplines. Be ready to share stories that highlight your teamwork and communication skills, especially in research projects. Think about working with different teams at university or any internships – this is where you can show how well you fit into University of Dundee's culture.
✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at University of Dundee. This shows your passion for the industry!
