Join us at the world-leading CRUK Cambridge Institute. We're a unique department of the University of Cambridge, core funded by Cancer Research UK's charitable activities, and we're eagerly searching for an experienced Senior Scientific Associate to join our Bioanalytical Mass Spectrometry Core Facility.
The core facility provides technical advice, direction, and service to scientists at all levels of the Institute and external collaborators. The core facility offers a diverse analytical service for the quantification of therapeutic molecules to a wide range of research and clinical based projects and trials (requiring GCP compliance).
The successful candidate will be responsible for the daily maintenance, calibration, and operation of Sciex Triple quadrupole and QTOF instruments (6500, and 6600) and associated UHPLC systems. They will be ensuring mass spectrometry equipment is running optimally, developing quantitative LC-MS/MS based assays together with other members of the core facility team, alongside validating LC-MS/MS based assays to the current OECD M10 guidelines to support clinical trials and providing a metabolomics service to the Institute research groups.
The Senior Scientific Associate within the Core Facility is an experienced scientist in both Liquid Chromatography hyphenated to mass spectrometry (LC-MS/MS) of small molecules/drug compounds, metabolomics, antibody-drug-conjugates (ADC), antibody-oligonucleotide conjugates (AOC), antibody-biopolymer conjugate (ABC), and bioanalysis (e.g. pharmacokinetics, toxicological assessments, and ICH GCP E6 (R3) compliant sample analysis for clinical trials). The role holder will act independently to provide sample analysis and LC-MS/MS scientific and technical support, training to other team members and members of research groups including Research Assistants, Postdoctoral Research Associates, Clinical Fellows and PhD students. The role is a hands‑on technical specialist role ensuring the day to day running of LC-MS/MS instrumentation, fit for purpose method development, GCP regulated and non‑regulated sample analysis, metabolomics data analysis, reporting, and instrument maintenance responsibilities to maintain an uninterrupted service.
Candidates will ideally have a postgraduate qualification or equivalent experience in a relevant discipline, coupled with advanced scientific and laboratory knowledge in the LC-MS/MS and experience in a GCP regulated environment as Analytical Project Manager. Experience in the analysis of large molecule therapeutics would be advantageous (proteins, mAb & ADCs).
We are principally seeking a Grade 7 Senior Scientific Associate, but will consider appointing at Grade 8 Principal Scientific Associate level (£42,254-£56,535) for an exceptionally experienced candidate.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.
Closing date: 31st August 2026
Interview Date: To be confirmed
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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Senior Scientific Associate (Bioanalytical Mass Spectrometry) in Cambridge employer: University of Cambridge
The University of Cambridge offers a dynamic and collaborative work environment, particularly within the Department of Oncology, where you will play a pivotal role in advancing cancer research. With a strong emphasis on employee growth, you will have access to professional development opportunities and the chance to work alongside leading experts in the field. The university's commitment to innovation and excellence ensures that your contributions will have a meaningful impact on clinical care and research outcomes.
