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- Tasks: Join an interdisciplinary team to explore cutting-edge molecular biology techniques.
- Company: University of Cambridge and University of Leicester, leaders in biochemistry research.
- Benefits: Fixed-term position with a competitive salary and opportunities for professional growth.
- Why this job: Make a real impact in the field of splicing regulation and collaborate with top researchers.
- Qualifications: PhD in Biochemistry, Chemistry, Biophysics or related field required.
- Other info: Exciting research environment with a focus on equality and diversity.
The predicted salary is between 36000 - 60000 £ per year.
We are seeking a highly motivated Post-Doctoral Research Associate to work on a new BBSRC-funded project 'Molecular grammar of a cell-type specific alternative splicing regulator' as part of an interdisciplinary team based at the Department of Biochemistry, University of Cambridge and the College of Life Sciences, University of Leicester. The project builds upon the discovery of the RNA binding protein RBPMS as a regulator of smooth muscle cell specific splicing and the finding that recombinant RBPMS can confer cell specific splicing in vitro, and self-assemble into phase separated states. The project will investigate the molecular and biophysical basis of splicing regulation using an array of state of the art biophysical, structural, molecular and chemical biology techniques, including single molecule analyses of splicing complexes.
The post-holder will work within the group of Professor Chris Smith in close collaboration with Dr Katherine Stott.
Responsibilities
- Molecular cloning, cell culture and transfection
- Analysis of RNA by RT-PCR
- Protein expression and purification from E coli
- Protein modification with fluorophores, photocrosslinking reagents and PRE probes for NMR
- Preparation of nuclear extracts
- In vitro splicing assays
- A range of biophysical assays
- Photochemical crosslinking
- Submission of samples for proteomics and subsequent data analysis
The postholder will work collaboratively with a current postdoc in the Stott lab on NMR work, and with a newly appointed postdoctoral researcher in the Leicester team.
Qualifications
Candidates should hold a PhD in Biochemistry, Chemistry, Biophysics or another relevant subject.
Funding and term
Fixed-term: The funds for this post are available for 3 years, from 1st May 2026 until 30th April 2029, in the first instance.
Application process
Click the 'Apply' button below to register an account with our recruitment system and apply online. For informal enquiries, please contact Professor Chris Smith via cwjs1@cam.ac.uk. For queries regarding the application process, please contact the Biochemistry HR Team via: personnel@bioc.cam.ac.uk. Please quote reference PH48297 on your application and in any correspondence about this vacancy.
Equality, diversity and eligibility
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate - Smith Group (Fixed Term) in Cambridge employer: University of Cambridge Vet School
Contact Detail:
University of Cambridge Vet School Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Research Associate - Smith Group (Fixed Term) in Cambridge
✨Tip Number 1
Network like a pro! Reach out to your contacts in the field, attend relevant seminars or workshops, and don’t be shy about introducing yourself to potential collaborators. You never know who might have a lead on that perfect Research Associate position!
✨Tip Number 2
Prepare for interviews by brushing up on your technical skills and understanding the latest research in your area. We recommend practising common interview questions with a friend or mentor to boost your confidence and ensure you can articulate your expertise clearly.
✨Tip Number 3
Showcase your passion for the project! When you get the chance to speak with the hiring team, make sure to express your enthusiasm for their research and how your background aligns with their goals. This can really set you apart from other candidates.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, it shows you’re serious about joining our team at the University of Cambridge and contributing to groundbreaking research.
We think you need these skills to ace Research Associate - Smith Group (Fixed Term) in Cambridge
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the specific role of Research Associate. Highlight relevant experience in molecular cloning, cell culture, and any biophysical techniques you've used. We want to see how your background fits with our project!
Craft a Compelling Cover Letter: Your cover letter should tell us why you're passionate about this research area. Share your motivation for applying and how your skills align with the responsibilities outlined in the job description. This is your chance to shine!
Follow Application Instructions: Don’t forget to quote reference PH48297 in your application! It’s super important for us to keep track of applications, so make sure you include it in both your application and any correspondence.
Apply Through Our Website: We encourage you to apply directly through our website. It’s the easiest way for us to receive your application and ensures you’re considered for the role. Plus, it’s a straightforward process—just click that 'Apply' button!
How to prepare for a job interview at University of Cambridge Vet School
✨Know Your Research
Dive deep into the specifics of the project and the research being conducted by Professors Smith and Stott. Familiarise yourself with the RNA binding protein RBPMS and its role in splicing regulation. This will not only show your genuine interest but also help you engage in meaningful discussions during the interview.
✨Showcase Your Skills
Be ready to discuss your hands-on experience with techniques mentioned in the job description, like molecular cloning, RT-PCR, and protein purification. Prepare examples from your past work that highlight your proficiency in these areas, as this will demonstrate your capability to contribute effectively to the team.
✨Collaborative Spirit
Since the role involves working closely with other researchers, emphasise your teamwork skills. Share experiences where you've successfully collaborated on projects, especially in interdisciplinary settings. This will reassure the interviewers that you can thrive in a collaborative environment.
✨Prepare Questions
Have a few thoughtful questions ready for your interviewers. Inquire about the specific goals of the project or the dynamics of the team. This shows that you're not just interested in the position but are also keen on understanding how you can fit into their research landscape.
