Senior Research Associate In Neuroscience

We are looking for a highly motivated postdoctoral research associate to join our team investigating the neurobiological basis memory and the role played by neuromodulator transmitter systems.

Within the hippocampus memory representations are stored and updated in a way that depends on uncertainty. This process relies on inputs that signpost new information and regulate the extent to which it is incorporated in future estimates by synaptic plasticity. We will test our central hypothesis that this signposting is performed by functionally overlapping neuromodulator systems interacting in an integrated fashion to signal different types of error and uncertainty. This signal enables appropriate updating of memories stored in the hippocampus providing realistic expectations on which to base decision making in uncertain situations, a fundamental process whose disruption is a core feature of multiple psychiatric disorders.

The role will involve electrophysiology and 2-photon imaging in rodent brain slices to measure where neuromodulation by acetylcholine, dopamine, noradrenaline and serotonin occurs in the hippocampal network and how this impacts network function and synaptic plasticity. These findings will inform a novel theoretical framework which will be iteratively refined by experiments to selectively manipulate neuromodulator release and downstream targets, providing mechanisms for how neuromodulators integrate to control synaptic plasticity. Ultimately this project will fundamentally reappraise the principles of neuromodulation and its therapeutic potential.

This is a highly collaborative project integrating expertise in neuromodulators and synaptic physiology (Mellor, Bristol), hippocampal representations (Dombeck, Northwestern) and computational modelling (Clopath, Imperial College). The team science approach will require individuals who think creatively and flourish in collaborative environments.

The role is part of a 7 year project that includes multiple posts within the team and is supported by the Wellcome Trust. The role is fixed term for 42 months with potential to extend.

What will you be doing?

You will:

• Conduct experiments in rodent brain slice tissue using electrophysiology and 2-photon microscopy.
• Stimulate and measure synaptic and neuronal responses using optogenetics and glutamate uncaging.
• Analyse large datasets using appropriate analytical approaches.
• Present data at meetings and to the research group.
• Collaborate across multiple teams.
• Update stakeholders regularly with progress and options for discussion.
• Develop research ideas, write papers and explore independent funding options.

You should apply if

You have:

• PhD in a relevant discipline, or equivalent research experience in an academic, industrial or clinical setting equivalent to a PhD
• A background in neuroscience and a passion for understanding the neurobiological basis of memory.
• Expertise in patch clamp electrophysiology and recording techniques (ideally in brain slices) is essential and experience with 2-photon imaging is desirable.
• Experience with data handling and analysis.
• A desire to work as part of a collaborative research team.

Senior Research Associate in Neuroscience London, GB