At a Glance
- Tasks: Conduct groundbreaking research on EBV and its impact on immune responses.
- Company: Join the University of Birmingham, a leader in medical research and innovation.
- Benefits: Competitive salary, professional development, and a supportive research environment.
- Other info: Be part of a diverse team committed to equality and sustainability.
- Why this job: Make a real difference in understanding rare diseases and contribute to vital research.
- Qualifications: PhD in immunology or virology with experience in myeloid-derived suppressor cells.
The predicted salary is between 36636 - 46049 £ per year.
Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health
Location: University of Birmingham, Edgbaston, Birmingham UK
Full time starting salary is normally in the range £36,636 to £46,049 with potential progression once in post to £48,822
Grade: 7 Full Time, Fixed Term contract up to July 2027
Closing date: 4th August 2026
Background
The research project is designed to help us understand how Epstein Barr virus drives (EBV) the pathogenesis of EBV-associated haemophagocytic lymphohistiocytosis (EBV-HLH). EBV-HLH is a rare but life-threatening hyperinflammatory disease that is poorly recognised clinically, often diagnosed late and has poor clinical outcomes. The EBV-HLH patients harbour large numbers of myeloid-derived suppressor cells that inhibit cytotoxic T cell growth and function, enabling the survival and expansion of the EBV-infected T/NK cell clones. However, we don’t yet understand how these MDSCs are generated, how they inhibit CTL function or how they alter the immune microenvironment to perpetuate the disease.
This project has four key aims:
- To determine how the EBV-infected cells drive the generation of PMN-MDSCs;
- To identify the key differences in the immune microenvironment compared to healthy controls;
- To use the metagenomics performed by the Breuer lab in UCL to design FlowRNA assays for the different viruses;
- To compare and contrast the changes to the immune microenvironment including MDSCs that are driven by different viruses.
Role Summary
To plan and deliver research in line with the University of Birmingham research strategy. To carry out research described in the Histionode grant. Analyse and interpret research findings and results. Contribute to generating funding. Contribute to patient and public understanding of EBV-associated HLH.
Main Duties
The responsibilities may include some but not all of the responsibilities outlined below:
- Develop research objectives and proposals for own or joint research, with assistance of a mentor if required;
- Contribute to writing bids for research funding;
- Analyse and interpret data;
- Apply knowledge in a way which develops new intellectual understanding;
- Disseminate research findings for publication, research seminars etc;
- Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline;
- Contribute to developing new models, techniques and methods;
- Undertake management/administration arising from research;
- Contribute to Departmental/School research-related activities and research-related administration;
- Contribute to public engagement activities of manifest benefit to the College and the University, often under supervision of a project leader;
- Collect research data; this may be through a variety of research methods, such as scientific experimentation, literature reviews, and research interviews;
- Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters;
- Provide guidance, as required, to support staff and any students who may be assisting with the research;
- Deal with problems that may affect the achievement of research objectives and deadlines;
- Promote equality and value diversity acting as a role model and fostering an inclusive environment.
Person Specification
- First degree in biological or biomedical sciences and a PhD (or near to completion) in immunology or virology;
- Extensive experience working with myeloid-derived suppressor cells, neutrophils and Epstein Barr virus;
- Fluency in optimising and performing high dimensional multicolour flow cytometry, culture of primary human lymphocytes and analysis of large data sets. Programming is desirable but not essential;
- High level analytical capability;
- Ability to communicate complex information clearly;
- Ability to assess resource requirements and use resources effectively;
- Understanding of and ability to contribute to broader management/administration processes;
- Contribute to the planning and organising of the specific research project;
- Co-ordinate own work with others to avoid conflict or duplication of effort;
- Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly.
Research Fellow - Department of Immunology and Immunotherapy - 107732 - Grade 7 in Birmingham employer: University of Birmingham
The University of Birmingham is an exceptional employer, offering a dynamic work environment that fosters creativity and collaboration. With a strong commitment to employee development, staff have access to numerous growth opportunities and professional training, all while enjoying the benefits of a flexible working arrangement. Located in a vibrant city, the university promotes a culture of inclusivity and support, making it an ideal place for those seeking meaningful and rewarding employment.
StudySmarter Expert Advice🤫
We think this is how you could land Research Fellow - Department of Immunology and Immunotherapy - 107732 - Grade 7 in Birmingham
✨Get Involved in Local Research Communities
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We think you need these skills to ace Research Fellow - Department of Immunology and Immunotherapy - 107732 - Grade 7 in Birmingham
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show University of Birmingham that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at University of Birmingham.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that University of Birmingham does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at University of Birmingham
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at University of Birmingham. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
✨Show Your Teamwork Skills
Biotech often involves collaboration across multiple disciplines. Be ready to share stories that highlight your teamwork and communication skills, especially in research projects. Think about working with different teams at university or any internships – this is where you can show how well you fit into University of Birmingham's culture.
✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at University of Birmingham. This shows your passion for the industry!
