About us
The Cancer Immunology Unit at the UCL Cancer Institute is a leading research group focused on understanding the immune mechanisms that drive cancer progression and therapeutic response. Led by Professor Sergio A Quezada, our research combines cutting-edge immunology, antibody engineering and translational cancer biology to develop innovative approaches for cancer treatment.
As part of the DEPICT research programme, we are investigating how the myeloid compartment within glioblastoma responds to antibody-based immune modulation. Our multidisciplinary approach integrates advanced in vivo models, high-dimensional spectral flow cytometry and single-cell technologies to generate new biological insights and accelerate therapeutic discovery.
We are committed to fostering a collaborative, inclusive and supportive research environment where scientific excellence, innovation and reproducible research are valued.
About the role
We are seeking a talented and motivated Research Fellow to join the Cancer Immunology Unit at the UCL Cancer Institute. This position will focus on investigating myeloid cell biology in glioblastoma and understanding how these cells respond to antibody-based therapeutic interventions.
The successful candidate will design and deliver mechanistic studies using orthotopic brain tumour models, apply advanced 35-40 colour spectral flow cytometry approaches and utilise single-cell transcriptomic technologies to characterise the tumour immune microenvironment. The role also includes antibody engineering, production and functional characterisation, alongside integration of complex datasets to drive scientific discovery.
Working closely with researchers, technicians and students, you will contribute to project delivery, publications, presentations and the broader scientific activities of the research programme. This is an exciting opportunity to conduct impactful research within a world-leading cancer immunology group
About you
You will hold, or be close to completing, a PhD in immunology, cancer biology or a closely related discipline and have a strong understanding of myeloid immunology and antibody biology.
You will bring substantial hands-on experience in advanced immunology research, including high-parameter spectral flow cytometry, single-cell RNA sequencing and antibody engineering techniques. You will have practical expertise working with mouse tumour models and a strong commitment to animal welfare, rigorous experimental design and reproducible research practices.
We are looking for an independent and collaborative scientist who can troubleshoot complex experiments, analyse and interpret data effectively and communicate scientific findings clearly. Experience in spatial transcriptomics, glioblastoma biology or integrative analysis of cytometry and transcriptomic datasets would be advantageous.
What we offer
As well as the exciting opportunities this role presents we also offer some great benefits some of which are below:
• 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days)
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• On-Site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance
Please visit https://www.ucl.ac.uk/work-at-ucl/rewards-and-benefits to find out more.
Our commitment to Equality, Diversity and Inclusion
As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here:
https://www.ucl.ac.uk/equality-diversity-inclusion/
Research Fellow employer: UNIVERSITY COLLEGE LONDON
UCL's Information Services Division (ISD) is an exceptional employer, offering a dynamic work environment that fosters innovation and collaboration among over 50,000 staff and students. With a commitment to employee growth, ISD provides extensive benefits including 41 days of holiday, a defined benefit pension scheme, and opportunities for professional development in cutting-edge technology areas. Located in the heart of London, UCL promotes a diverse and inclusive culture, making it an ideal place for those looking to make a meaningful impact in higher education.
