MRC Postdoctoral Research Scientist in London

Overview: This opportunity aims to advance our understanding of genome architecture and epigenetic regulation using cutting-edge single-cell and multi-omics technologies.

About the Laboratory: The Vaquerizas Laboratory at the MRC Laboratory of Medical Sciences is internationally recognised for pioneering research in 3D genome organisation, epigenomics, and single-cell multiomics. Our recent work focuses on understanding key processes in human and mouse development, male infertility, and epitranscriptomics, using advanced genomic and transcriptomic technologies. We take a multidisciplinary approach, integrating molecular biology, genomics, computational biology, and systems-level analyses to address fundamental biological questions. The lab fosters a collaborative and supportive research environment, encouraging independent scientific growth and offering access to state-of-the-art core facilities and comprehensive training opportunities.

Thematic Research Interests:

• Single-cell multiomics and spatial transcriptomics
• 3D genome architecture and nuclear organisation
• Epigenomics and epitranscriptomics in development and disease
• Model systems including human, mouse, flies, worm, and beyond

Personal research interests and innovative ideas within these themes are strongly encouraged.

About the Role: This position is ideal for a candidate with a strong foundation in molecular biology who is eager to expand into computational biology. The role offers the opportunity to work hands-on with innovative single-cell and spatial technologies while being supported in developing programming and data analysis skills. Projects may include generating and analysing complex genomic datasets, contributing to method optimisation, and engaging in collaborative research initiatives across the institute.

Responsibilities:

• Design, plan, and conduct high-quality, independent research aligned with the project aims.
• Critically analyse, interpret, and present experimental data with scientific rigor and reproducibility.
• Develop, refine, and implement experimental methods, protocols, and analytical techniques.
• Stay current with relevant scientific literature and integrate new findings and methodologies into ongoing research.
• Collaborate effectively with internal lab members and external partners, including participation in interdisciplinary projects.
• Provide mentorship, training, and guidance to junior researchers and PhD students.
• Contribute to the academic life of the institute by attending and participating in lab meetings, journal clubs, and seminar programmes.
• Present research findings at national and international conferences and meetings.
• Publish results in high-quality, peer-reviewed scientific journals.
• Support the smooth running of the laboratory by contributing to shared responsibilities and day-to-day operations.
• Support the preparation of research grant applications, including contributing to the development of proposals and gathering preliminary data.

Additional Information: These are MRC Postdoctoral Research Scientist positions designed to support postdoctoral training and help establish successful research careers. During the fellowship, we are committed to providing mentorship for career development, including support for communication skills, grant writing, and scientific leadership. We offer a highly attractive benefits package, including a competitive salary and pension scheme, as well as access to world-class research facilities and training programmes.

Person Requirements:

• Education / Qualifications / Training required: PhD or due for completion in 6 months (or equivalent experience) in a relevant field (e.g., bioinformatics, computational biology, molecular biology, cell biology, biochemistry, developmental biology, genetics).
• Previous work experience required: Strong hands-on experience in genomic molecular biology methods (e.g., RNA-seq, ATAC-seq, Cut&Run), proven experience with 3D genome data generation (e.g., Micro-C or Hi-C) and analysis, previous experience with Drosophila genetics and stock management, advanced computational skills (R, Python), experience with multi-omics technologies (e.g., RNA-seq, ATAC-seq, Micro-C).
• Knowledge and experience: Strong conceptual understanding of genomics, gene regulation, developmental biology, computational biology approaches, experience in generating high-quality figures for publication, excellent written communication skills in English, first-author publication or pre-print, experience in assembling manuscripts for publication, experience presenting scientific data at national or international conferences.
• Personal skills / Behaviours / Qualities: Enthusiastic and motivated, with a genuine interest in scientific discovery and learning, independent research capability, collaborative mindset, eagerness to learn, creativity and problem-solving skills, excellent verbal communication skills in English, good interpersonal skills, commitment to knowledge sharing and mentoring, highly organised and diligent, adaptability and openness to integrating new techniques and collaborating across disciplines.

Applicants should submit one CV, a brief cover letter describing how the candidate meets the person specifications and the motivation for the post, and the names and contact details of two scientific references.

About Us: UKRI – UK Research and Innovation is an organisation that brings together the seven disciplinary research councils, Research England, and Innovate UK. Together, we build an independent organisation with a strong voice and vision ensuring the UK maintains its world-leading position in research and innovation. Supporting some of the world’s most exciting and challenging research projects, we develop and operate some of the most remarkable scientific facilities in the world.

How we support EDI in the workforce: At UKRI, we believe that everyone has a right to be treated with dignity and respect, and to be provided with equal opportunities to thrive and succeed in an environment that enables them to do so. We also value diversity of thought and experience within inclusive groups, organisations, and the wider community.

Disability Confident Employer: As users of the disability confident scheme, any candidate who opts into the scheme and best meets the essential criteria will be shortlisted for interview. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

How to apply: Online applications only preferred for this role. Please submit a CV and covering letter which clearly outlines how you fulfil the criteria specified along with your motivation for UKRI and the role. Ensure that the job reference number is included in the filename description of each document uploaded.

About the Team: The Laboratory Institute of Medical Sciences (LMS) is a Medical Research Council funded research institute at the Hammersmith Hospital campus of Imperial College London, with around 400 biomedical researchers undertaking multidisciplinary and internationally-competitive science. Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding, and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability, or age.