At a Glance
- Tasks: Lead clinical trials for innovative therapies in Huntington's disease and manage research teams.
- Company: UCL Huntington’s Disease Centre, a leader in neurodegenerative research.
- Benefits: Competitive salary, 41 days holiday, pension scheme, and on-site gym.
- Other info: Flexible working options and commitment to diversity and inclusion.
- Why this job: Make a real difference in patients' lives through groundbreaking research.
- Qualifications: Registered medical practitioner with experience in neurology and clinical trials.
The predicted salary is between 62075 - 78670 € per year.
The UCL Huntington’s Disease Centre, based in the Department of Neurodegenerative Disease at the UCL Queen Square Institute of Neurology, is led by Professor Sarah Tabrizi (Director) and Professor Gillian Bates (Co Director). Established in 2015 in a purpose‑built environment, the Centre brings together laboratory based mechanistic research and clinical neuroscience to enable the translation of fundamental discoveries into early phase, first in human studies. The Centre integrates preclinical research, biomarker development and clinical trial delivery, including proof of concept studies conducted through the Leonard Wolfson Experimental Neurology Centre, ahead of larger multi‑centre phase II and III clinical trials.
About the role: You will primarily support the clinical development aims of a range of antisense oligonucleotide, gene therapy, and small molecule huntingtin lowering trials led by Professor Sarah Tabrizi at the UCL Huntington’s Disease Centre in collaboration with UCLH and the Leonard Wolfson Experimental Neurology Centre (LWENC). Acting as Chief Sub‑Investigator you will lead on the day‑to‑day management of all clinical trials led by Professor Tabrizi. Key responsibilities include:
- Training and supervision of Clinical Research Fellows working on the trials
- Providing information to patients about the studies ensuring informed consent is obtained from participants
- Performing clinical and neurological assessments in accordance with Good Clinical Practice (GCP)
- Completing case report forms in accordance with study protocols
- Responding to data queries and feedback from study monitoring
- Performing lumbar punctures and associated procedures for cerebrospinal fluid (CSF) collection
- Providing rare out‑of‑hours medical care/advice for trial participants
- Participating in the multidisciplinary HD and neurogenetics clinics at the NHNN
An honorary contract will be sought from UCLH NHS Foundation Trust, for which a DBS check will be required. The post is available to start from 03 August 2026 and is supported by philanthropic funding for two years in the first instance. There may be the possibility for a successful candidate that has their CCT to apply for a future Honorary Consultant appointment at UCLH NHNN, with concomitant NHS responsibilities, subject to NHS eligibility requirements and a successful Honorary Consultant interview process.
About you: You’ll be a registered medical practitioner permitted to practise in the UK, will have completed general medical training to ST6 or equivalent level, and have experience of working in Neurology and an interest in Huntington’s disease. Substantial experience of working in Huntington’s disease clinical trials, in‑depth knowledge of GCP and clinical trial governance, and demonstrable experience and proficiency in lumbar puncture are also essential for this role. This role meets the eligibility requirements for a skilled worker certificate of sponsorship or a global talent visa under UK Visas and Immigration legislation. Therefore, UCL welcomes applications from international applicants who require a visa.
What we offer: The role is offered in the range of £62,075 – £78,670 per annum including London Allowance, on the CL, RDPS, or StR scale, dependent on NHS contract and/or stage of clinical training. As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below:
- 41 Days holiday (27 days annual leave, 8 bank holiday and 6 closure days)
- Additional 5 days’ annual leave purchase scheme
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle to work scheme and season ticket loan
- On‑site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme: Staff Support Service
We will consider applications to work on a part‑time, flexible, and job share basis wherever possible.
Our commitment to Equality, Diversity and Inclusion: The Institute prides itself on operating in an all‑inclusive environment irrespective of personal, physical, or social characteristics. Teamwork is highly valued, individual strengths are recognised and celebrated, and we are committed to advancing the careers of everyone. 12% of Institute staff are actively working on Equality, Diversity and Inclusion (EDI) initiatives; visit our EDI website for more information about our initiatives and priorities. The Institute also holds an Athena SWAN Gold award, in recognition of our commitment and demonstrable impact in advancing gender equality. As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all roles, and women in Grade 9 and 10 roles.
Senior Clinical Research Fellow employer: UK Dementia Research Institute
The UCL Huntington’s Disease Centre offers an exceptional work environment for the Senior Clinical Research Fellow role, combining cutting-edge research with clinical practice in a purpose-built facility. Employees benefit from generous leave policies, a supportive culture that values diversity and inclusion, and opportunities for professional growth within a prestigious institution. With a commitment to advancing careers and fostering teamwork, UCL is dedicated to creating a workplace where every individual can thrive and contribute to meaningful advancements in neurodegenerative disease research.
Contact Detail:
UK Dementia Research Institute Recruiting Team
StudySmarter Expert Advice🤫
We think this is how you could land Senior Clinical Research Fellow
✨Tip Number 1
Network like a pro! Reach out to professionals in the field of neurology and clinical research. Attend conferences, webinars, or local meetups to connect with people who can give you insights or even refer you to opportunities.
✨Tip Number 2
Prepare for interviews by brushing up on your knowledge of Huntington’s disease and recent advancements in clinical trials. We recommend practising common interview questions and scenarios related to your role to show you're ready to hit the ground running.
✨Tip Number 3
Showcase your experience! When you get the chance to speak about your past roles, highlight specific projects or trials you've worked on, especially those involving GCP and lumbar punctures. This will demonstrate your hands-on expertise.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen. Plus, we love seeing candidates who are proactive and engaged with our mission at StudySmarter.
We think you need these skills to ace Senior Clinical Research Fellow
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to highlight your experience in neurology and clinical trials, especially any work related to Huntington's disease. We want to see how your background aligns with the role, so don’t hold back on showcasing relevant skills!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you’re passionate about this role and how your experience makes you the perfect fit. We love seeing genuine enthusiasm for the work we do at the UCL Huntington’s Disease Centre.
Showcase Your Clinical Skills:Since this role involves hands-on clinical work, be sure to highlight your proficiency in lumbar punctures and any other relevant procedures. We want to know you can hit the ground running and contribute to our clinical trials from day one!
Apply Through Our Website:Don’t forget to apply through our website! It’s the best way to ensure your application gets to us directly. Plus, it shows you’re serious about joining our team at the UCL Huntington’s Disease Centre.
How to prepare for a job interview at UK Dementia Research Institute
✨Know Your Stuff
Make sure you brush up on your knowledge of Huntington's disease and the latest advancements in clinical trials. Familiarise yourself with the specific antisense oligonucleotide and gene therapy approaches mentioned in the job description. This will show your genuine interest and expertise during the interview.
✨Demonstrate Your Experience
Be ready to discuss your previous experience in clinical trials, especially in neurology. Prepare examples that highlight your proficiency in lumbar punctures and your understanding of Good Clinical Practice (GCP). This will help the interviewers see how you can contribute to their ongoing projects.
✨Showcase Your Leadership Skills
As a Chief Sub-Investigator, you'll be leading a team. Think of instances where you've trained or supervised others, and be prepared to share these experiences. Highlight your ability to manage day-to-day operations effectively while ensuring compliance with study protocols.
✨Ask Thoughtful Questions
Prepare some insightful questions about the UCL Huntington’s Disease Centre and its research focus. This not only shows your enthusiasm for the role but also helps you gauge if the environment aligns with your career goals. Consider asking about future projects or collaborations they have in mind.
