At a Glance
- Tasks: Investigate neurodegenerative diseases and contribute to groundbreaking research in a collaborative environment.
- Company: Join a leading research institute focused on dementia and neurodegeneration.
- Benefits: 41 days holiday, pension scheme, gym access, and flexible working options.
- Other info: Inclusive workplace committed to diversity and career advancement for all.
- Why this job: Make a real impact in the fight against neurodegenerative diseases while developing your skills.
- Qualifications: BSc in Biomedical Sciences with experience in iPSC culture and molecular biology techniques.
The predicted salary is between 30000 - 40000 € per year.
The Research Department of Neurodegenerative Disease is focused on the study of neurodegenerative diseases causing dementia and related disorders. The Department has a strong focus on mechanistic dissection of genetic, molecular cellular and neuropathological processes which underlie neurodegeneration in particular diseases and across the neurodegeneration spectrum. A related touchstone of our research is to identify pathophysiological mechanisms and markers that link molecular pathology to clinical phenotypes of neurodegenerative disease. The Department has strong collaborative links with the UK Dementia Research Institute and with the ARUK UCL Drug Discovery Institute.
The Isaacs lab, based in the Department, investigates the molecular mechanisms underlying frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We are particularly interested in the C9orf72 gene, which is a common cause of both FTD and ALS and the CHMP2B gene, which is a rare cause of FTD. We use a multidisciplinary approach including disease modelling in mice, Drosophila, primary neurons and iPS cell-derived neurons. We combine these model systems with analysis of patient tissue in order to ensure the relevance of our work to the disease process we are studying. We are also working to translate our research findings into potential therapies using gene therapy and high-throughput screening approaches.
About the role: We have developed novel approaches for interrogating C9orf72 sense and antisense repeat-derived transcripts. You will assess the contributions of these pathologies to cellular dysfunction in C9orf72 ALS patient and control iPS lines. The role will include differentiation of iPSCs into cortical and motor neuron subtypes using transcription factor based, and small molecule-mediated, differentiation, survival assays and molecular analyses of C9orf72- and TDP-43-associated pathologies. The post is available immediately and funded by Target ALS until 31 December 2027 in the first instance.
About you: You will have a BSc in a relevant discipline, such as Biomedical Sciences, together with experience in iPSC culture and neuronal differentiation. You will also have experience with molecular biology techniques, including qPCR, as well as immunostaining, microscopy and image analysis. Excellent communication, interpersonal, organisational and time management skills are essential for this role.
What we offer: As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below:
- 41 Days holiday (27 days annual leave, 8 bank holiday and 6 closure days)
- Additional 5 days’ annual leave purchase scheme
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle to work scheme and season ticket loan
- On-site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme: Staff Support Service
We will consider applications to work on a part-time, flexible, and job share basis wherever possible.
Our commitment to Equality, Diversity and Inclusion: The Institute prides itself on operating in an all-inclusive environment irrespective of personal, physical, or social characteristics. Teamwork is highly valued, individual strengths are recognised and celebrated, and we are committed to advancing the careers of everyone. 12% of Institute staff are actively working on Equality, Diversity and Inclusion (EDI) initiatives; visit our EDI website for more information about our initiatives and priorities. The Institute also holds an Athena SWAN Gold award, in recognition of our commitment and demonstrable impact in advancing gender equality. As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all roles, and women in Grade 9 and 10 roles.
Research Technician employer: UK Dementia Research Institute
As a leading research institution in the field of neurodegenerative diseases, we offer an exceptional work environment that fosters collaboration and innovation. Our commitment to employee growth is evident through our extensive benefits package, including 41 days of holiday, a defined benefit pension scheme, and opportunities for flexible working arrangements. Located in London, we pride ourselves on our inclusive culture, where diversity is celebrated and teamwork is paramount, making it an ideal place for passionate individuals to contribute to meaningful research.
Contact Detail:
UK Dementia Research Institute Recruiting Team
StudySmarter Expert Advice🤫
We think this is how you could land Research Technician
✨Tip Number 1
Network like a pro! Reach out to people in the field of neurodegenerative diseases, especially those connected to the UK Dementia Research Institute. A friendly chat can lead to opportunities that aren’t even advertised yet.
✨Tip Number 2
Show off your skills! When you get an interview, be ready to discuss your experience with iPSC culture and molecular biology techniques. Bring examples of your work or even a portfolio to demonstrate your expertise.
✨Tip Number 3
Be prepared for technical questions! Brush up on your knowledge about C9orf72 and TDP-43 pathologies. Understanding these topics will show your genuine interest and help you stand out during interviews.
✨Tip Number 4
Apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, it shows you’re serious about joining our team and contributing to groundbreaking research.
We think you need these skills to ace Research Technician
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the Research Technician role. Highlight your experience with iPSC culture, molecular biology techniques, and any relevant projects that showcase your skills in neurodegenerative disease research.
Craft a Compelling Cover Letter:Your cover letter should tell us why you're passionate about neurodegenerative diseases and how your background fits with our research focus. Be specific about your experiences and how they relate to the work we do at the Isaacs lab.
Showcase Your Skills:Don’t forget to mention your excellent communication, organisational, and time management skills. These are essential for the role, so give us examples of how you've demonstrated these in past experiences.
Apply Through Our Website:We encourage you to apply through our website for a smooth application process. It’s the best way to ensure your application gets to the right people and stands out in our system!
How to prepare for a job interview at UK Dementia Research Institute
✨Know Your Science
Make sure you brush up on the latest research related to neurodegenerative diseases, especially focusing on C9orf72 and TDP-43. Being able to discuss recent findings or breakthroughs in these areas will show your genuine interest and understanding of the field.
✨Showcase Your Skills
Prepare to talk about your experience with iPSC culture and neuronal differentiation. Be ready to provide specific examples of techniques you've used, like qPCR or immunostaining, and how they relate to the role you're applying for.
✨Communicate Effectively
Since excellent communication skills are essential for this role, practice explaining complex scientific concepts in a clear and concise manner. This will not only help you during the interview but also demonstrate your ability to work collaboratively within a team.
✨Ask Insightful Questions
Prepare thoughtful questions about the department's research focus and collaborative projects, such as those with the UK Dementia Research Institute. This shows that you're engaged and eager to contribute to their ongoing work.
