At a Glance
- Tasks: Analyse extrachromosomal DNA evolution and develop detection methods for cancer research.
- Company: Join a leading university with a vibrant, collaborative research environment.
- Benefits: 41 days holiday, pension scheme, gym access, and employee support services.
- Other info: Encouraging diverse applicants to foster creativity and innovation.
- Why this job: Make a real impact in cancer research while working with cutting-edge genomic technologies.
- Qualifications: PhD in relevant field, experience in genomics, and programming skills in C++, Python, or R.
The predicted salary is between 55000 - 65000 £ per year.
We are seeking a collaborative and self‑motivated bioinformatician post‑doctoral fellow to work on extrachromosomal DNA (ecDNA) in a vibrant, highly collegiate environment. ecDNA are circular genomic structures that can drive ultra‑high copy number amplification and correlate with poor clinical outcomes. This project will analyse ecDNA evolution over time using single‑cell RNA/ATAC sequencing and develop a ctDNA‐based approach for detecting and monitoring ecDNA to support biomarker and treatment development.
The research will utilise existing whole‑genome sequencing data from the TRACERx lung‑cancer evolution and PEACE research autopsy programmes, and will be part of the eDyNAmiC Cancer Grand Challenge. The work will involve analysing large multi‑region matched primary and metastatic tumour datasets, developing computational pipelines for ecDNA detection, and integrating ctDNA biomarker data to provide translational insights.
Successful applicants should have a proven track record of publications, previous experience with genomics data analysis, and fluency in at least one of the following programming languages: C++, Python or R. Strong skills in genomics and desirably experience in tumour biology, ctDNA/blood‑based biomarkers, evolutionary biology, statistics or mathematics are required.
Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B, with payment at Grade 7 backdated to the date of final submission of the PhD thesis.
What we offer:
- 41 days holiday (including 27 days annual leave, 8 bank holidays and 6 closure days)
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle‑to‑work scheme and season ticket loan
- On‑site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme: Staff Support Service
Our commitment to Equality, Diversity and Inclusion: As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, fairness and inclusiveness, and to being a place where everyone belongs. We especially encourage applications from candidates likely to be underrepresented in UCL’s workforce, including people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.
Research Fellow - Bioinformatics – Extrachromosomal DNA and tumour evolution Scientist employer: UK Dementia Research Institute
As a Research Fellow in Bioinformatics at UCL, you will thrive in a dynamic and inclusive environment that champions collaboration and innovation. With exceptional benefits such as 41 days of holiday, a defined benefit pension scheme, and a commitment to diversity, UCL not only supports your professional growth but also fosters a culture where every voice is valued. Join us in London, where your contributions to cutting-edge cancer research will make a meaningful impact on patient outcomes.
Contact Details:
UK Dementia Research Institute Recruitment Team
StudySmarter Expert Advice🤫
We think this is how you could land Research Fellow - Bioinformatics – Extrachromosomal DNA and tumour evolution Scientist
✨Network Like a Pro
Get out there and connect with folks in the bioinformatics field! Attend conferences, join online forums, or even hit up local meetups. The more people you know, the better your chances of landing that dream role.
✨Show Off Your Skills
When you get the chance to chat with potential employers, don’t hold back! Share your experience with genomics data analysis and programming languages like Python or R. Let them see how your skills can contribute to their projects.
✨Tailor Your Approach
Before reaching out to companies, do your homework! Understand their research focus and how your background in ecDNA and tumour evolution fits in. A personalised approach shows you’re genuinely interested and can make you stand out.
✨Apply Through Our Website
Don’t forget to check out our website for job openings! Applying directly through us not only streamlines the process but also gives you a better shot at being noticed. We’re excited to see what you bring to the table!
We think you need these skills to ace Research Fellow - Bioinformatics – Extrachromosomal DNA and tumour evolution Scientist
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to highlight your experience with genomics data analysis and programming languages like C++, Python, or R. We want to see how your skills align with the role of a Research Fellow in bioinformatics.
Craft a Compelling Cover Letter:Your cover letter should tell us why you're passionate about ecDNA research and how your background makes you a great fit for our team. Be sure to mention any relevant publications or projects that showcase your expertise.
Showcase Your Collaborative Spirit:Since we value collaboration, make sure to include examples of how you've worked effectively in teams. Highlight any interdisciplinary projects or experiences that demonstrate your ability to thrive in a collegiate environment.
Apply Through Our Website:Don't forget to apply through our website! It’s the best way to ensure your application gets to us directly. Plus, it shows you're keen on joining our vibrant community at StudySmarter.
How to prepare for a job interview at UK Dementia Research Institute
✨Know Your Stuff
Make sure you brush up on your knowledge of extrachromosomal DNA and tumour evolution. Familiarise yourself with the latest research and methodologies in bioinformatics, especially single-cell RNA/ATAC sequencing. This will not only help you answer technical questions but also show your genuine interest in the field.
✨Showcase Your Skills
Prepare to discuss your experience with programming languages like C++, Python, or R. Be ready to provide examples of how you've used these skills in previous projects, particularly in genomics data analysis. Highlight any publications or significant contributions you've made in this area.
✨Ask Insightful Questions
Interviews are a two-way street! Prepare thoughtful questions about the research team's current projects, the eDyNAmiC Cancer Grand Challenge, and how your role would contribute to their goals. This shows that you're not just interested in the position, but also in the team's work and future direction.
✨Emphasise Collaboration
Since the role requires a collaborative spirit, be ready to share examples of how you've successfully worked in teams before. Discuss how you handle differing opinions and how you contribute to a positive team environment. This will demonstrate that you can thrive in their highly collegiate setting.
