At a Glance
- Tasks: Lead clinical trials for innovative Huntington's disease therapies and manage research teams.
- Company: UCL Huntington’s Disease Centre, a leader in neurodegenerative research.
- Benefits: Competitive salary, 41 days holiday, and opportunities for professional growth.
- Other info: International applicants welcome; potential for future NHS consultant roles.
- Why this job: Make a real difference in patients' lives through groundbreaking research.
- Qualifications: Registered medical practitioner with experience in neurology and clinical trials.
The predicted salary is between 62075 - 78670 € per year.
The UCL Huntington’s Disease Centre, based in the Department of Neurodegenerative Disease at the UCL Queen Square Institute of Neurology, is led by Professor Sarah Tabrizi (Director) and Professor Gillian Bates (Co Director). Established in 2015 in a purpose‑built environment, the Centre brings together laboratory based mechanistic research and clinical neuroscience to enable the translation of fundamental discoveries into early phase, first in human studies. The Centre integrates preclinical research, biomarker development and clinical trial delivery, including proof of concept studies conducted through the Leonard Wolfson Experimental Neurology Centre, ahead of larger multi‑centre phase II and III clinical trials.
About the role: You will primarily support the clinical development aims of a range of antisense oligonucleotide, gene therapy, and small molecule huntingtin lowering trials led by Professor Sarah Tabrizi at the UCL Huntington’s Disease Centre in collaboration with UCLH and the Leonard Wolfson Experimental Neurology Centre (LWENC). Acting as Chief Sub‑Investigator you will lead on the day‑to‑day management of all clinical trials led by Professor Tabrizi.
Key responsibilities include:
- Training and supervision of Clinical Research Fellows working on the trials.
- Providing information to patients about the studies ensuring informed consent is obtained from participants.
- Performing clinical and neurological assessments in accordance with Good Clinical Practice (GCP).
- Completing case report forms in accordance with study protocols.
- Responding to data queries and feedback from study monitoring.
- Performing lumbar punctures and associated procedures for cerebrospinal fluid (CSF) collection.
- Conducting procedures relating to the intrathecal drug administration.
- Providing rare out‑of‑hours medical care/advice for trial participants.
- Participating in the multidisciplinary HD and neurogenetics clinics at the NHNN.
An honorary contract will be sought from UCLH NHS Foundation Trust, for which a DBS check will be required. The post is available to start from 03 August 2026 and is supported by philanthropic funding for two years in the first instance. There may be the possibility for a successful candidate that has their CCT to apply for a future Honorary Consultant appointment at UCLH NHNN, with concomitant NHS responsibilities, subject to NHS eligibility requirements and a successful Honorary Consultant interview process.
About you: You’ll be a registered medical practitioner permitted to practise in the UK, will have completed general medical training to ST6 or equivalent level, and have experience of working in Neurology and an interest in Huntington’s disease. Substantial experience of working in Huntington’s disease clinical trials, in‑depth knowledge of GCP and clinical trial governance, and demonstrable experience and proficiency in lumbar puncture are also essential for this role. This role meets the eligibility requirements for a skilled worker certificate of sponsorship or a global talent visa under UK Visas and Immigration legislation. Therefore, UCL welcomes applications from international applicants who require a visa.
What we offer: The role is offered in the range of £62,075 – £78,670 per annum including London Allowance, on the CL, RDPS, or StR scale, dependent on NHS contract and/or stage of clinical training. As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below: 41 Days holiday (27 days annual leave 8
Senior Clinical Research Fellow in London employer: UK Dementia Research Institute
The UCL Huntington’s Disease Centre is an exceptional employer, offering a dynamic work environment that fosters innovation and collaboration in the field of neurodegenerative diseases. With a strong emphasis on employee growth, you will have access to extensive training opportunities and the chance to lead groundbreaking clinical trials, all while being part of a supportive team dedicated to making a meaningful impact on patient care. Located in the heart of London, the Centre provides a unique blend of academic excellence and practical experience, ensuring that your contributions are both valued and impactful.
Contact Detail:
UK Dementia Research Institute Recruiting Team
StudySmarter Expert Advice🤫
We think this is how you could land Senior Clinical Research Fellow in London
✨Tip Number 1
Network like a pro! Reach out to professionals in the field of neurology and clinical research. Attend conferences, webinars, or local meet-ups to make connections that could lead to job opportunities.
✨Tip Number 2
Prepare for interviews by brushing up on your knowledge of Huntington's disease and recent advancements in clinical trials. We want you to be able to discuss your experience confidently and show your passion for the role.
✨Tip Number 3
Don’t forget to showcase your skills! During interviews, highlight your experience with lumbar punctures and GCP compliance. We need to see how your expertise aligns with the responsibilities of the role.
✨Tip Number 4
Apply through our website! It’s the best way to ensure your application gets noticed. Plus, we love seeing candidates who are proactive about their job search.
We think you need these skills to ace Senior Clinical Research Fellow in London
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the role of Senior Clinical Research Fellow. Highlight your experience in neurology and clinical trials, especially any work related to Huntington's disease. We want to see how your background aligns with what we're looking for!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you're passionate about this role and how your skills make you a perfect fit. Don’t forget to mention your experience with GCP and lumbar punctures, as these are key for us.
Showcase Your Team Spirit:Since you'll be training and supervising Clinical Research Fellows, it's important to demonstrate your leadership skills. Share examples of how you've worked in teams or led projects in the past. We love seeing collaboration in action!
Apply Through Our Website:We encourage you to apply through our website for a smooth application process. It’s the best way for us to receive your application and keep track of everything. Plus, it shows you’re keen on joining our team at StudySmarter!
How to prepare for a job interview at UK Dementia Research Institute
✨Know Your Stuff
Make sure you brush up on the latest research and developments in Huntington's disease and clinical trials. Familiarise yourself with the specific trials led by Professor Tabrizi, as well as the methodologies used in antisense oligonucleotide and gene therapy. This will show your genuine interest and expertise during the interview.
✨Showcase Your Experience
Be ready to discuss your previous experience in neurology and clinical trials, especially any work related to Huntington's disease. Prepare specific examples of your involvement in trials, your understanding of Good Clinical Practice (GCP), and how you've managed patient interactions and informed consent processes.
✨Practice Clinical Scenarios
Since the role involves performing lumbar punctures and other clinical procedures, it’s a good idea to prepare for questions or scenarios related to these tasks. Think about how you would handle complications or patient concerns, and be ready to demonstrate your clinical judgement and skills.
✨Engage with the Team
The role requires collaboration with various teams, so be prepared to discuss how you work within multidisciplinary settings. Highlight your leadership experience, especially in training and supervising others, and express your enthusiasm for contributing to a team dedicated to advancing Huntington's disease research.
