At a Glance
- Tasks: Analyse extrachromosomal DNA evolution and develop detection methods for cancer research.
- Company: Join a leading university with a vibrant, collaborative research environment.
- Benefits: 41 days holiday, pension scheme, gym access, and enhanced family leave.
- Other info: Diversity is valued; we encourage applications from underrepresented groups.
- Why this job: Make a real impact in cancer research while developing your bioinformatics skills.
- Qualifications: PhD in relevant field, experience with genomics data, and programming skills in C++, Python, or R.
The predicted salary is between 55000 - 65000 £ per year.
About the role
We are seeking a collaborative and self‑motivated bioinformatician post‑doctoral fellow to work on extrachromosomal DNA (ecDNA) in a vibrant, highly collegiate environment. ecDNA are circular genomic structures that can drive ultra‑high copy number amplification and correlate with poor clinical outcomes. This project will analyse ecDNA evolution over time using single‑cell RNA/ATAC sequencing and develop a ctDNA‐based approach for detecting and monitoring ecDNA to support biomarker and treatment development. The research will utilise existing whole‑genome sequencing data from the TRACERx lung‑cancer evolution and PEACE research autopsy programmes, and will be part of the eDyNAmiC Cancer Grand Challenge.
The work will involve analysing large multi‑region matched primary and metastatic tumour datasets, developing computational pipelines for ecDNA detection, and integrating ctDNA biomarker data to provide translational insights.
About you
Successful applicants should have a proven track record of publications, previous experience with genomics data analysis, and fluency in at least one of the following programming languages: C++, Python or R. Strong skills in genomics and desirably experience in tumour biology, ctDNA/blood‑based biomarkers, evolutionary biology, statistics or mathematics are required. Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B, with payment at Grade 7 backdated to the date of final submission of the PhD thesis.
What we offer
- 41 days holiday (including 27 days annual leave, 8 bank holidays and 6 closure days)
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle‑to‑work scheme and season ticket loan
- On‑site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme: Staff Support Service
Our commitment to Equality, Diversity and Inclusion
As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, fairness and inclusiveness, and to being a place where everyone belongs. We especially encourage applications from candidates likely to be underrepresented in UCL’s workforce, including people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.
Research Fellow - Bioinformatics – Extrachromosomal DNA and tumour evolution Scientist in London employer: UK Dementia Research Institute
As a Research Fellow in Bioinformatics at UCL, you will thrive in a dynamic and inclusive environment that champions collaboration and innovation. With exceptional benefits such as 41 days of holiday, a defined benefit pension scheme, and access to an on-site gym, UCL prioritises employee well-being and professional growth. Join us in our commitment to advancing cancer research while being part of a diverse community that values every individual's contribution.
Contact Details:
UK Dementia Research Institute Recruitment Team
StudySmarter Expert Advice🤫
We think this is how you could land Research Fellow - Bioinformatics – Extrachromosomal DNA and tumour evolution Scientist in London
✨Network Like a Pro
Get out there and connect with folks in your field! Attend conferences, workshops, or even local meetups. We all know that sometimes it’s not just what you know, but who you know that can help land that dream job.
✨Show Off Your Skills
Don’t just sit back and wait for the interview to showcase your talents. Create a portfolio or GitHub repository where you can display your projects and coding skills. This way, potential employers can see your work in action!
✨Ace the Informational Interview
Reach out to people already working in roles you’re interested in and ask for an informational interview. It’s a great way to learn more about the position and make a good impression. Plus, they might just think of you when a job opens up!
✨Apply Through Our Website
When you find a role that excites you, apply through our website! It shows you’re genuinely interested and helps us keep track of your application. Plus, we love seeing candidates who are proactive about their job search.
We think you need these skills to ace Research Fellow - Bioinformatics – Extrachromosomal DNA and tumour evolution Scientist in London
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to highlight your experience with genomics data analysis and programming languages like C++, Python, or R. We want to see how your skills align with the role, so don’t hold back on showcasing relevant projects!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you’re passionate about ecDNA research and how your background makes you a great fit for our team. Keep it engaging and personal – we love to see your enthusiasm!
Showcase Your Publications:If you’ve got a proven track record of publications, make sure to highlight them in your application. We’re looking for candidates who can demonstrate their contributions to the field, so include links or references to your work!
Apply Through Our Website:Don’t forget to apply through our website! It’s the best way to ensure your application gets into the right hands. Plus, it shows us you’re serious about joining our vibrant community at StudySmarter.
How to prepare for a job interview at UK Dementia Research Institute
✨Know Your Stuff
Make sure you brush up on your knowledge of extrachromosomal DNA and tumour evolution. Familiarise yourself with the latest research and methodologies in bioinformatics, especially those related to ctDNA and single-cell sequencing. This will not only help you answer technical questions but also show your genuine interest in the field.
✨Showcase Your Skills
Prepare to discuss your experience with programming languages like C++, Python, or R. Be ready to provide examples of how you've used these skills in previous projects, particularly in genomics data analysis. Highlight any publications or significant contributions you've made in this area to demonstrate your expertise.
✨Collaborative Spirit
Since the role emphasises collaboration, think of examples where you've successfully worked in a team. Be prepared to discuss how you handle differing opinions and contribute to a positive team environment. This will show that you're not just a great researcher but also a team player.
✨Ask Insightful Questions
Prepare thoughtful questions about the research projects, the team dynamics, and the future direction of the work. This shows that you're engaged and serious about the position. It’s also a great way to determine if the environment is the right fit for you.
