Research Fellow

The Research Fellow will join a research team led by Prof. Nick Greene, that focuses on mechanisms underlying the development of the nervous system, together with the causes and treatment of associated developmental and post-natal disorders. Work in our laboratory uses mouse and cellular models to investigate the genetic and developmental basis of congenital anomalies with a particular focus on neural tube defects (NTDs), such as spina bifida. This project will investigate the impact of heat exposure on risk and mitigation of NTDs. Among non-genetic risk factors for NTDs, raised maternal temperature during pregnancy is known to increase the risk of NTDs in their baby. There is a concern that the increased frequency and severity of extreme heat events resulting from climate change may increase susceptibility to NTDs. In this project we will use mouse models to investigate this concept, and to test the hypothesis that there may be an additive interaction of heat exposure with embryonic

genetic susceptibility and sub-optimal maternal nutrition to increase risk of NTDs and/or heart defects. We will investigate the cellular and molecular mechanisms by which raised temperature causes NTDs, and test whether raised temperature compromises key metabolic networks. We will also test whether appropriately timed nutrient supplementation can ameliorate this susceptibility. This post is funded for 2 years in the first instance.

The appointee will use genetic mouse models that are established in our lab, as well as novel models that we are generating in parallel projects. They will use embryo culture and in vivo models and analyse mechanisms underlying NTDs using a range of approaches. This will include transcriptomics, functional studies, use of fluorescent reporters and biochemical analysis. Experience using mouse models, mRNA/protein expression analysis, transcriptomics and microscopy (light and confocal) will be an advantage. The successful candidate will have a PhD in an area of developmental biology, experience with use of mouse genetic models (ideally at mid-gestation stages), imaging and molecular biology.

• Annual leave

• Company pension

• Cycle to work scheme

• On-site gym

• Season ticket loan, As well as the exciting opportunities this role presents we also offer some great benefits some of which are below: 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days) Defined benefit career average revalued earnings pension scheme (CARE) Cycle to work scheme and season ticket loan On-Site nursery On-site gym Enhanced maternity, paternity and adoption pay Employee assistance programme: Staff Support Service Discounted medical insurance