At a Glance
- Tasks: Drive innovative non-clinical PKPD strategies and collaborate on drug development projects.
- Company: UCB, a global biopharmaceutical leader focused on neurology and immunology.
- Benefits: Hybrid work model, supportive culture, and opportunities for career growth.
- Other info: Join a diverse team dedicated to pushing boundaries and creating value.
- Why this job: Make a real impact on patients' lives through cutting-edge research and collaboration.
- Qualifications: PhD in relevant field and expertise in PKPD methods and drug development.
The predicted salary is between 63000 - 77000 £ per year.
Make your mark for patients. We are looking for a Principal Scientist, Non-Clinical PKPD, who is innovative and agile to join us in our Clinical Development Sciences Group, based at the R&D site in Slough, UK, then Windlesham, Surrey (2027).
About the role: The Non-Clinical PKPD group sits within the Quantitative Clinical Pharmacology (QCP) function of Early Clinical Development & Translational Science (ECD-TS) Department. Our goal is to use integrated quantitative approaches as an essential strategic driver from target to market to bring differentiated solutions to patients. We are driving the quantitative integrated strategy of pharmacokinetics and pharmacology (e.g. PKPD, Systems modelling and clinical pharmacology/pharmacometrics) together with DMPK activities throughout the entirety of the lifetime of projects, from target identification through to life cycle management.
Who you'll work with: We operate and collaborate closely with colleagues in Development Sciences, which, as a department, is responsible for providing strategy and support in bioanalysis, immunogenicity, safety, pathology, and regulatory activities. Work with external partners, academic institutions, CROs and consultants as required.
What you'll do:
- Develop and drive the nonclinical PKPD strategy for projects.
- Communicate effectively ensuring implementation in projects.
- Ensure translation from in vitro data and in vivo nonclinical studies to prediction of efficacy and safety in patients.
- Initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build a thorough knowledge of drug pharmacology and PKPD, leading to quantitative translation to the clinic.
- Build PKPD models of sufficient complexity to allow hypothesis testing and inform decision-making.
- Represent the interests of QCP internally and externally in matters relevant to mechanistic PKPD and contribute to enhancing the scientific reputation of Non-Clinical PKPD, QCP and UCB.
- Provide required support and input into regulatory study protocols, reports and summaries, and regulatory submission documents.
Interested? For this role you will need the following education, experience and skills:
- PhD in relevant discipline (pharmacology, pharmaceutical sciences, pharmacokinetics/pharmacodynamics, system biology or related fields).
- Good understanding of pharmacology and pharmacologic processes related to disease and drug mechanisms.
- Expertise and proven application of PKPD methods and concepts in support of drug discovery and development; systems modelling experience would be advantageous.
- Demonstrated experience in developing and executing effective non-clinical PKPD strategies from early discovery through to clinic.
- Demonstrated experience and leadership skills working within a matrix environment with a wide range of internal stakeholders including Non-Clinical Safety, Bioanalysis, Clinical Pharmacology and Translational Medicine.
- Experience in using modelling and simulation packages such as Phoenix, Berkeley Madonna, R and Monolix.
Are you ready to 'go beyond' to create value and make your mark for patients? If this sounds like you, then we would love to hear from you!
About us: UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are over 9,000 people in all four corners of the globe, inspired by patients and driven by science.
Why work with us? At UCB, we don't just complete tasks, we create value. We aren't afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected, and has equal opportunities to do their best work. We 'go beyond' to create value for our patients, and always with a human focus, whether that's on our patients, our employees, or our planet. Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential. At UCB, we've embraced a hybrid-first approach to work, bringing teams together in local hubs to foster collaborative curiosity. Unless expressly stated in the description or precluded by the nature of the position, roles are hybrid with 40% of your time spent in the office. UCB is an equal opportunity employer. All employment decisions will be made without regard to any characteristic protected by applicable laws.
Principal Scientist PK/PD in High Wycombe employer: Ucb Group
UCB is an exceptional employer that fosters a collaborative and innovative work culture, where employees are encouraged to push boundaries and create meaningful value for patients. Located in Slough, our hybrid-first approach allows for flexibility while working alongside experienced scientists in a supportive environment that prioritises personal growth and career development. Join us to be part of a team that values inclusivity and empowers you to make your mark in the biopharmaceutical industry.
