Principal Scientist / Associate Director, Biology

Principal Scientist / Associate Director, Biology

Join to apply for the Principal Scientist / Associate Director, Biology role at Transition Bio, Inc.

Principal Scientist / Associate Director, Biology

Join to apply for the Principal Scientist / Associate Director, Biology role at Transition Bio, Inc.

Direct message the job poster from Transition Bio, Inc.

Transition Bio is an innovative, early-stage biotechnology company with the vision of being the world leader in drug discovery targeting biomolecular condensates. Our multidisciplinary teams bring together expertise in cell biology, biophysics, biochemistry, medicinal chemistry, engineering, and data science to build first-in-class technology platforms for condensate analysis and therapeutic discovery.

We are looking for aPrincipal Scientist or Associate Director of Biology to join our team in Cambridge, UK. This is an exciting opportunity to contribute to cutting-edge science in an innovative and collaborative biotech environment. The ideal candidate will bringstrong hands-on experimental expertise in cell biology andexperience managing CROs forrunning in vivo PK/PD and efficacy studies to support our advancing pipeline.

Key Responsibilities include, but are not limited to:

• Design and execute in vitro and in vivo studies to support target validation, compound optimization, and mechanism-of-action investigations.
• Manage in vivo studies at external partners, including pharmacokinetics (PK), pharmacodynamics (PD), and efficacy studies in relevant disease models.
• Maintain a strong hands-on presence in the lab, developing and optimizing assays for compound profiling, biomarker analysis, and cellular readouts.
• Build and maintain productive CRO relationships, including study design, troubleshooting, and timeline/data quality oversight.
• Work cross-functionally with chemistry, DMPK, and data science teams to drive projects from early discovery to preclinical development.
• Mentor and guide junior scientists while fostering a high-performing and collaborative culture.
• Analyze, interpret, and present data to scientific and strategic stakeholders across the organization.

Required Qualifications and Experience:

• PhD in Cell Biology, Pharmacology, or a related field, and/or accomplished relevant industry experience in biotech or pharma.
• Hands-on experience in establishing and running cell-based assays for drug discovery, including reporter assays, imaging-based phenotyping, or biomarker readouts.
• Demonstrated experience running in vivo PK/PD and efficacy studies in Oncology and/or Neurodegeneration at CROs, including study design, execution, and data interpretation.
• Prior CRO management and experience overseeing outsourced biology studies.
• Excellent communication, problem-solving, and organizational skills.
• Ability to thrive in a dynamic, fast-paced biotech environment.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

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