At a Glance
- Tasks: Join a dynamic team to advance drug discovery through innovative protein biochemistry techniques.
- Company: Transition Bio, a cutting-edge biotech firm linked to Cambridge and Harvard.
- Benefits: Collaborative environment, professional growth, and the chance to work on groundbreaking projects.
- Other info: Fast-paced, multidisciplinary setting with opportunities for career advancement.
- Why this job: Make a real impact in drug discovery while working with diverse, talented professionals.
- Qualifications: MSc in relevant fields or BSc with industry experience; hands-on lab skills required.
The predicted salary is between 42750 - 52250 £ per year.
Transition Bio is an innovative, early-stage biotechnology company with the vision of being the world leader in drug discovery targeting biological condensates.
At Transition Bio, multidisciplinary teams with diverse skillsets in biology, biophysics, chemistry, engineering, and machine learning work closely together, building first-in-class technology for high-throughput screening to aid hit identification and driving drug discovery.
With close affiliation to Cambridge and Harvard universities, our approach is truly original and encompasses a growing collection of novel technologies and methodologies.
The Opportunity
We are seeking a talented and enthusiastic Research Associate with a strong background in protein science.
The successful candidate will enjoy working collaboratively within a multidisciplinary team and applying a broad range of molecular biology, protein biochemistry and biophysical techniques to support and advance our drug discovery projects.
You will have the opportunity to contribute to innovative therapeutic projects in a dynamic research environment where scientific excellence, collaboration and innovation are at the core of everything we do.
Key Responsibilities
- Design and generate constructs for recombinant protein expression using molecular biology techniques, including PCR, Gibson Assembly, site directed mutagenesis, plasmid preparation and sequence verification.
- Recombinant expression of proteins in bacterial, insect cell (Sf9/baculovirus) and mammalian systems.
- Protein purification using ÄKTA FPLC systems and a range of techniques including affinity, ion exchange and size exclusion chromatography (SEC).
- Assess protein quality and stability using biochemical and biophysical methods such as SDS-PAGE, Western blotting, SEC, differential scanning fluorimetry (DSF), and other analytical techniques.
- Work closely with senior members of the team to assist in developing, optimising and executing biochemical and biophysical assays such as HTRF, Alpha Screen, GCI (similar to SPR) to support target validation and small-molecule drug discovery projects.
- Assist in experimental data analysis, preparation of technical reports and scientific presentations.
- Maintain accurate experimental records in accordance with company quality standards.
- Plan, prioritise and execute experiments both independently and in collaboration with scientists across biology, chemistry and computational disciplines.
- Required Qualifications and Experience
- MSc (or equivalent) in Biochemistry, Molecular Biology, Chemical Biology, or Biotechnology.
Candidates with a BSc degree and relevant industrial experience will also be considered.
- Hands-on lab experience in molecular biology, including construct design, cloning, plasmid preparation and sequence analysis.
- Practical experience in recombinant protein expression and purification using bacterial and insect cell or mammalian expression systems.
- Experience with operating chromatography systems e. g. ÄKTA and familiarity with a broad range of protein purification techniques.
- Knowledge of biochemical and biophysical assays. Familiarity with HTRF, Alpha Screen, SPR, GCI, BLI, MST, DSF or related technologies is highly desirable.
- Experience supporting assay development or high-throughput screening would be advantageous.
Strong analytical and problem-solving skills with the ability to troubleshoot experiments and interpret data.
- Excellent written and verbal communication skills, with experience preparing technical reports, scientific documentation and project presentations.
- A proactive, collaborative and can-do attitude and the ability to thrive in a fast-paced, multidisciplinary environment.
- Previous experience working within the biotechnology or pharmaceutical industry.
- Experience with baculovirus generation and insect cell culture.
- Familiarity with automated liquid handling systems or high-throughput screening platforms.
- Experience working with challenging protein targets such as intrinsically-disordered proteins and proteins that undergo phase separation.
- Experience using scientific data analysis software such as Graph Pad Prism, Benchling, Dotmatics.
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Research Associate, Protein Biochemistry and Biophysics in Cambridge employer: Transition Bio, Inc.
Transition Bio is an exceptional employer that fosters a collaborative and innovative work culture, ideal for those passionate about advancing drug discovery. Located in close proximity to prestigious institutions like Cambridge and Harvard, employees benefit from unique networking opportunities and access to cutting-edge research methodologies. With a strong emphasis on employee growth and development, the company encourages team members to contribute to groundbreaking therapeutic projects in a dynamic environment where scientific excellence is paramount.
StudySmarter Expert Advice🤫
We think this is how you could land Research Associate, Protein Biochemistry and Biophysics in Cambridge
✨Get Involved in Local Research Communities
Tap into local biotechnology meetups and research forums. These are great places to mingle with industry professionals, share your passion, and even discover unadvertised job openings. It's all about getting your face known in the field!
✨Leverage University Alumni Networks
If you're a recent grad, don’t underestimate the power of your university’s alumni network! Reach out to alumni working in biotechnology to gather tips about job openings at companies like Transition Bio, Inc.. You'd be surprised how willing people are to help out a fellow grad!
✨Show Off Your Projects
Curate a portfolio showcasing any research projects or internships you've completed in biotechnology. This tangible evidence of your skills can really impress employers when you chat with them at networking events or interviews. It's about making that killer first impression!
✨Stay Up-to-Date with Industry Trends
Biotech is a fast-paced field, so keeping yourself updated with the latest advancements is crucial. Attend industry conferences, webinars, or workshops to broaden your knowledge and meet potential employers. Plus, it’ll give you fantastic talking points for your interviews at places like Transition Bio, Inc.!
We think you need these skills to ace Research Associate, Protein Biochemistry and Biophysics in Cambridge
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Transition Bio, Inc. that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at Transition Bio, Inc..
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Transition Bio, Inc. does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at Transition Bio, Inc.
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Transition Bio, Inc.. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
✨Show Your Teamwork Skills
Biotech often involves collaboration across multiple disciplines. Be ready to share stories that highlight your teamwork and communication skills, especially in research projects. Think about working with different teams at university or any internships – this is where you can show how well you fit into Transition Bio, Inc.'s culture.
✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at Transition Bio, Inc.. This shows your passion for the industry!
