Associate Principal Scientist – Antibody Engineering and Novel Modalities, Biologics Engineerin[...]

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Associate Principal Scientist – Antibody Engineering and Novel Modalities, Biologics Engineering, Oncology R&D, Cambridge

Client:

Location:

Cambridge, United Kingdom

Job Category:

–

EU work permit required:

Yes

Job Reference:

aede71d8a8fc

Job Views:

6

Posted:

05.05.2025

Expiry Date:

19.06.2025

Job Description:

We are seeking a motivated Associate Principal Scientist, with significant experience in antibody engineering and leading early drug discovery projects, to support our therapeutic discovery pipeline through the innovative use of AstraZeneca’s world-class antibody discovery technologies.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world’s most serious diseases.

Site Description

The DISC, our newly built building, will bring together the company’s R&D activities in a groundbreaking centre and headquarters, designed to reflect AstraZeneca’s innovative approach to research.

Business Area

The Biologics Engineering team is responsible for discovering and optimizing biological candidate drugs to support various therapy pipelines and developing in-house biologics discovery platforms and novel drug modalities.

Responsibilities

You will drive biologics drug delivery from early discovery to candidate nomination, working with multidisciplinary teams. You will lead projects involving large molecules like antibodies, sdAb, peptides, etc., especially in AZ’s CVRM portfolio, managing pipeline projects and pre-project target validation.

Essential Qualifications

• PhD with proven experience or BSc/higher degree with extensive antibody and protein engineering experience.
• Leadership in early drug project management for large molecules.
• Deep knowledge of large molecule modalities such as mAb, Bi/Multispecifics, VH, VHH.
• Design and execution of antibody isolation and optimization campaigns.
• Understanding of genotype/phenotype relationships in antibodies.
• Experience with molecular biology techniques like PCR, cloning, mutagenesis, and sequence analysis.
• Ability to analyze large data sets, troubleshoot, and maintain high-quality records.
• Strong problem-solving, organizational, and communication skills.

Desirable Qualifications

• Experience with bioinformatics tools like Geneious Prime.
• Experience with NGS, computational methods, and machine learning in antibody design.
• Experience working with non-standard antibody conjugates such as ADCs.

Why AstraZeneca

We are pioneers transforming cancer treatment and improving patient outcomes.

Next Steps

Apply today to join our mission to eliminate cancer as a cause of death. Competitive salary and benefits.

Additional Information

Close Date: 10/07/2024

Follow AstraZeneca on social media and LinkedIn for updates.

Posted on: 26-Jun-2024

We promote an inclusive environment and welcome applications from all qualified candidates. Reasonable adjustments are available upon request.

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