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- Tasks: Lead research on synaptic dysfunction in neurodegeneration and manage iPSC-derived neuronal cultures.
- Company: Join a collaborative team at the University of Sheffield, focused on impactful neuroscience research.
- Benefits: 41 days annual leave, flexible working, generous pension, and professional development opportunities.
- Why this job: Make a real difference in understanding neurodegenerative diseases while advancing your career.
- Qualifications: PhD in neuroscience or related field; experience with iPSC models and synaptic biology preferred.
- Other info: Supportive environment with diverse staff networks and recognition awards for outstanding contributions.
The predicted salary is between 33500 - 46000 ÂŁ per year.
Overview
Applications are invited for a postdoctoral research associate (PDRA) to join a collaborative research programme investigating the role of synaptic dysfunction and impaired neurotransmission in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD).
You will work within a team of two PDRAs and two senior research technicians under a 5-year MRC-funded collaborative research programme.
In this post you will lead the maintenance of curated iPSCs and the generation of iPSC‑derived neuronal cultures in which synaptic function will be examined using state‑of‑the‑art electrophysiological and microscopy‑based assays.
Candidates are strongly encouraged to contact Prof Kurt De Vos (k.de_vos@sheffield.ac.uk) and Dr Matthew Livesey (m.r.livesey@sheffield.ac.uk) to discuss the project prior to application.
Main Duties And Responsibilities
- Undertake research in line with project requirements.
- To set‑up and run experiments in relation to the project in consultation with the PIs
- Manage data collection, analysis and storage on a day‑to‑day basis.
- Work independently and as part of a team to deliver the research objectives in line with the project outline.
- Direct the work of supporting technicians
- Liaise closely with other academics, advisers and administrators relevant to the study.
- Take a lead role in the analysis, interpretation and writing up of data
- Read and review literature as appropriate.
- Assist in the writing of the project reports and publications.
- Contribute to conference presentations, research advisory group meetings
- Attend and contribute to project/lab meetings and research advisory group meetings.
- Support project reporting requirements, including research project progress reports and finance management and reporting
- Contribute to the supervision and support of PhD students and MSc students working in the lab
- Carry out other duties, commensurate with the grade and remit of the post
Person Specification
Our diverse community of staff and students recognises the unique abilities, backgrounds, and beliefs of all. We foster a culture where everyone feels they belong and is respected. Even if your past experience doesn\’t match perfectly with this role\’s criteria, your contribution is valuable, and we encourage you to apply. Please ensure that you reference the application criteria in the application statement when you apply.
Criteria
Essential Or Desirable
- A PhD in neuroscience, molecular/cell biology or a related discipline (applicants near completion of their PhD are welcome to apply)
- Essential Application Experience working with human in vitro iPSC-based models (iPSC maintenance, deriving defined cell types from iPSCs)
- Essential Application and Interview Demonstrable experience in molecular, biochemistry and cell biology
- Essential Application and Interview Demonstrable experience in synaptic biology
- Desirable Application and Interview Demonstrable Experience In Primary Rodent (mouse/rat) Neuron Cultures
- Desirable Application and Interview Demonstrable experience in lentiviral and AAV viral vectors
- Desirable Application and Interview Demonstrable experience in assays of neuronal or synaptic function (electrophysiology, imaging (e.g., pHluorin)-based assays)
- Desirable Application and Interview Previous experience with Drosophila
- Desirable Application and Interview Experience working on neurodegenerative diseases
- Desirable Application and Interview Experience of delivering high quality research
- Essential Application and Interview
Grade
7.3
Salary
ÂŁ38,784
Work arrangement
Full‑time
Duration
ASAP – 3 years with possible extension to 4 years
Line manager
Professor Kurt de Vos
Direct reports
Professor Kurt de Vos
Our website
https://sheffield.ac.uk/sitran
For informal enquiries about this job please contact Prof Kurt De Vos (k.de_vos@sheffield.ac.uk) and Dr Matthew Livesey (m.r.livesey@sheffield.ac.uk)
Next steps in the recruitment process
It is anticipated that the selection process will take place shortly after the advert closing date. We plan to let candidates know if they have progressed to the selection stage as soon as possible. If you need any support, equipment or adjustments to enable you to participate in any element of the recruitment process you can contact the Staffing Team at clinmed‑staffing@sheffield.ac.uk.
Our vision and strategic plan
We are the University of Sheffield. This is our vision: sheffield.ac.uk/vision (opens in new window).
What We Offer
- A minimum of 41 days annual leave including bank holiday and closure days (pro rata) with the ability to purchase more.
- Flexible working opportunities, including hybrid working for some roles.
- Generous pension scheme.
- A wide range of discounts and rewards on shopping, eating out and travel.
- A variety of staff networks, providing opportunities for social interaction, peer support and personal development (for example, Race Equality, LGBT+, Women’s and Parent’s networks).
- Recognition Awards to reward staff who go above and beyond in their role.
- A commitment to your development access to learning and mentoring scheme integrated with our Academic Career Pathways
- A range of generous family‑friendly policies
- paid time off for parenting and caring emergencies
- support for those going through the menopause
- paid time off and support for fertility treatment
- and more
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Research Associate - Synaptic dysfunction in neurodegeneration employer: The University of Sheffield
Contact Detail:
The University of Sheffield Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Research Associate - Synaptic dysfunction in neurodegeneration
✨Tip Number 1
Get in touch with Prof Kurt De Vos or Dr Matthew Livesey before applying. A quick chat can give you insights into the project and show your genuine interest, which can really set you apart from other candidates.
✨Tip Number 2
Show off your skills during interviews! Be ready to discuss your experience with iPSC models and synaptic biology. Bring examples of your past work to demonstrate how you can contribute to the team.
✨Tip Number 3
Network like a pro! Attend relevant conferences or seminars where you might meet people from the lab or similar fields. Building connections can lead to valuable recommendations and insider tips.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, it shows you’re serious about joining our team at Sheffield.
We think you need these skills to ace Research Associate - Synaptic dysfunction in neurodegeneration
Some tips for your application 🫡
Know Your Stuff: Before you start writing, make sure you understand the role and its requirements. Dive into the job description and highlight the key skills and experiences they’re looking for. This will help us tailor your application to show you’re the perfect fit!
Be Personal: When writing your application, don’t just list your qualifications. Share your passion for neuroscience and neurodegeneration! We want to see your personality shine through, so let us know why this role excites you and how you can contribute to our team.
Showcase Relevant Experience: Make sure to reference the essential and desirable criteria in your application statement. Highlight your experience with iPSC models, synaptic biology, and any relevant research projects. This is your chance to show us what you’ve got!
Check Your Work: Before hitting send, give your application a thorough proofread. Typos and errors can distract from your amazing qualifications. If possible, ask a friend or colleague to review it too. We want to see your best work when you apply through our website!
How to prepare for a job interview at The University of Sheffield
✨Know Your Research
Before the interview, dive deep into the specifics of synaptic dysfunction and neurodegeneration. Familiarise yourself with recent studies and breakthroughs in ALS and FTD. This will not only show your passion but also help you engage in meaningful discussions with the interviewers.
✨Showcase Your Skills
Be ready to discuss your experience with iPSC models and any relevant techniques you've mastered, like electrophysiology or microscopy. Prepare specific examples of how you've successfully applied these skills in past projects, as this will demonstrate your hands-on expertise.
✨Prepare Questions
Think of insightful questions to ask about the research programme and the team dynamics. This shows your genuine interest in the role and helps you assess if it's the right fit for you. Questions about collaboration opportunities or future project directions can be particularly engaging.
✨Emphasise Teamwork
Since this role involves working closely with other researchers and technicians, highlight your ability to collaborate effectively. Share examples of how you've contributed to team projects in the past, focusing on communication and support for others, which are key in a research environment.
