Find a job 
Featured Companies 
Featured Universities 
For Companies At a Glance
- Tasks: Join a dynamic team to research zebrafish models for brain diseases and contribute to groundbreaking studies.
- Company: Be part of the Geoffrey Jefferson Brain Research Centre at the University of Manchester.
- Benefits: Enjoy a fantastic pension scheme, health services, generous leave, and discounts at major retailers.
- Other info: Flexible working options available in a supportive, multi-disciplinary environment.
- Why this job: Make a real impact in neuroscience while working with innovative zebrafish disease models.
- Qualifications: Experience in zebrafish disease modelling and strong in vivo skills are essential.
The predicted salary is between 30000 - 40000 £ per year.
This is an outstanding opportunity for a Research Technician, with a background in zebrafish disease modelling, to work within the Brain Inflammation group under the supervision of Dr Paul Kasher. The post holder will be part of the Geoffrey Jefferson Brain Research Centre, which is based at the University of Manchester. The candidate will support the aims of a 12-month Pilot grant funded by Alzheimer’s Research UK. This innovative project will characterise white matter defects in a newly described zebrafish model of COL4A1-related cerebral small vessel disease (cSVD). The overarching aim of this pilot study is to assess whether vascular dementia-like phenotypes exist in a new zebrafish model of cSVD and determine whether we can use the advantages of zebrafish disease modelling to identify VaD modifiers in future studies.
Specifically, we hypothesise that myelin/WM pathology and cognitive deficits accompany the neurovascular phenotypes observed in the mutant col4a1 zebrafish model of cSVD. Furthermore, as we have previously shown that MMP9 inhibition can reduce ICH severity in this model, we further hypothesise that MMP9 inhibition can also attenuate myelin/WM pathology.
Objectives
- Determine the extent of white matter pathology in the brains of the col4a1Δ20 zebrafish line during larval and adult stages.
- Quantify cognitive impairment phenotypes in the col4a1Δ20 zebrafish line in adulthood.
- Define the role of MMP9 expression on white matter and/or cognitive behaviours in the col4a1Δ20 zebrafish line.
Addressing these three objectives will validate the col4a1Δ20 zebrafish line as an essential model for drug discovery in the context of VaD in future pre‑clinical studies. This position offers an ideal opportunity for an enthusiastic, well‑motivated individual to work as part of a sociable multi‑disciplinary team. The ideal candidate will have excellent in vivo (zebrafish) skills, and will be able to work with minimal supervision. Experience of zebrafish disease modelling is essential for the position.
Benefits
- Fantastic market‑leading Pension scheme
- Excellent employee health and wellbeing services including an Employee Assistance Programme
- Exceptional starting annual leave entitlement, plus bank holidays
- Additional paid closure over the Christmas period
- Local and national discounts at a range of major retailers
As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit. Our University is positive about flexible working – you can find out more here. Hybrid working arrangements may be considered.
Research Technician in Neuroscience employer: The University of Manchester
Contact Detail:
The University of Manchester Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Research Technician in Neuroscience
✨Tip Number 1
Network like a pro! Reach out to your connections in the neuroscience field, especially those who might know about zebrafish research. Attend relevant seminars or workshops to meet potential colleagues and mentors – you never know who might have the inside scoop on job openings!
✨Tip Number 2
Prepare for interviews by brushing up on your zebrafish disease modelling knowledge. Be ready to discuss your hands-on experience and how it relates to the specific objectives of the role. Practise answering common interview questions with a focus on your skills and how they align with the team’s goals.
✨Tip Number 3
Show your enthusiasm! When you get the chance to chat with potential employers, let your passion for neuroscience and zebrafish research shine through. Share your ideas on how you can contribute to the project and the team – it’ll make you stand out from the crowd!
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets noticed. Plus, we love seeing candidates who take the initiative to engage directly with us. So, go ahead and submit your application – we’re excited to see what you bring to the table!
We think you need these skills to ace Research Technician in Neuroscience
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your experience with zebrafish disease modelling and any relevant skills. We want to see how your background aligns with the exciting research we're doing at the Geoffrey Jefferson Brain Research Centre.
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Tell us why you're passionate about neuroscience and how you can contribute to our team. Be sure to mention specific projects or experiences that relate to the role.
Showcase Your Team Spirit: We're all about collaboration here at StudySmarter. In your application, highlight any experiences where you've worked in a multi-disciplinary team. We love seeing candidates who thrive in a sociable environment!
Apply Through Our Website: Don't forget to submit your application through our website! It’s the best way for us to keep track of your application and ensure it gets the attention it deserves. We can't wait to hear from you!
How to prepare for a job interview at The University of Manchester
✨Know Your Zebrafish Inside Out
Make sure you brush up on your knowledge of zebrafish disease modelling, especially in relation to cSVD. Be ready to discuss specific techniques you've used and how they relate to the objectives of the project. This shows you're not just familiar with the species but also understand its relevance to the research.
✨Show Enthusiasm for the Research
Express genuine interest in the project and the Brain Inflammation group. Talk about why this research excites you and how it aligns with your career goals. A positive attitude can make a big difference and show that you're a great fit for the team.
✨Prepare Questions for Your Interviewers
Think of insightful questions to ask Dr Paul Kasher or other team members. This could be about the future direction of the research or how the team collaborates. It demonstrates your engagement and helps you assess if the role is right for you.
✨Highlight Your Teamwork Skills
Since this position involves working within a multi-disciplinary team, be prepared to share examples of how you've successfully collaborated in the past. Emphasise your ability to work independently as well, as the job requires minimal supervision.