At a Glance
- Tasks: Lead clinical pharmacology projects and perform advanced modelling and analysis.
- Company: Join a dynamic biotech company focused on innovative drug development.
- Benefits: Competitive salary, professional growth, and collaborative work environment.
- Other info: Fast-paced environment with opportunities for career advancement.
- Why this job: Make a real impact in drug development with cutting-edge modelling techniques.
- Qualifications: PhD or MSc in life sciences, plus 5+ years in clinical development.
The predicted salary is between 60000 - 80000 £ per year.
Our client, a Biotech company, now seeks a Clinical Pharmacologist with a strong quantitative background to support clinical development through clinical pharmacology, modelling & simulation, and pharmacokinetic analysis. The role is primarily technical and execution-focused, with responsibility for study-level delivery across all phases including PK analysis, PBPK and population PK/PD modelling, for the interpretation of clinical and nonclinical data, preparation of clinical pharmacology deliverables, and presentation of results in cross-functional settings. The role requires close collaboration with Clinical Operations, Biostatistics, Regulatory, CMC, Toxicology, and Non-clinical, and the ability to translate quantitative analyses into clear, development-relevant conclusions. This position requires scientific leadership, independence, and accountability for high-quality outputs, while working in a fast-paced environment.
Responsibilities:
- Provide hands-on PK analysis and modelling support for clinical studies (Phase 1–3), including noncompartmental analysis, population PK/PD modelling, and PBPK modelling, as appropriate.
- Develop, implement, maintain, and interpret PBPK and population PK/PD models to support dose selection, study design, device/formulation bridging, special populations, and regulatory questions.
- Contribute to the design, analysis, interpretation, and reporting of clinical pharmacology components of clinical studies, under the direction of the Head of Clinical Pharmacology.
- Author and/or contribute to high-quality clinical pharmacology deliverables, including study reports or sections thereof, protocols, investigator brochures, modelling reports, and responses to regulatory questions.
- Integrate clinical pharmacology and pharmacometrics insights with nonclinical PK/ADME, clinical safety, and efficacy data to support development decisions.
- Support cross-functional teams by presenting analyses and modelling results at study team meetings, internal governance forums, and selected external interactions.
- Collaborate effectively with Clinical Operations, Biostatistics, and external vendors/CROs to ensure appropriate data flow, analysis standards, and timelines.
- Critically evaluate data quality, assumptions, and limitations in PK and modelling analyses, and clearly communicate uncertainty and impact on development decisions.
Requirements:
- BSc in Life Science, plus Post-graduate qualification (i.e. PhD or MSc) in a relevant life sciences or quantitative discipline (e.g. clinical pharmacology, pharmacometrics, pharmaceutical sciences, biomedical, or similar).
- 5+ years of experience in pharmaceutical, biotechnology, and/or CRO environments, with hands-on involvement in clinical development programs.
- Hands-on PK analysis experience using Phoenix WinNonlin.
- Hands-on PBPK modelling experience using tools such as Simulations Plus GastroPlus, SimCYP and/or PK-Sim/MoBi, including model development, verification, and interpretation.
- Experience using R (RStudio) and/or Python for data handling, analysis, and visualization.
- Preference for population PK/PD modelling experience using Phoenix NLME, including model development and application.
- Demonstrated ability to analyse complex datasets, build and interpret models, and communicate results clearly and practically to multidisciplinary audiences.
- Willing to expand into adjacent areas (e.g. DMPK, TK, clinical trial operational support) as required by program needs.
For further details, please contact Larry on +353 1 – 2302400.
Principal Clinical Pharmacologist, PBPK/PD Modelling in Wolverhampton employer: The RFT Group
As a leading Biotech company, we pride ourselves on fostering a collaborative and innovative work environment that empowers our employees to excel in their roles. With a strong focus on professional development, we offer numerous opportunities for growth and advancement, alongside competitive benefits that support work-life balance. Join us in our fast-paced setting where your expertise in clinical pharmacology will directly contribute to groundbreaking advancements in healthcare.
StudySmarter Expert Advice🤫
We think this is how you could land Principal Clinical Pharmacologist, PBPK/PD Modelling in Wolverhampton
✨Network Like a Pro
Get out there and connect with people in the industry! Attend conferences, webinars, or local meetups related to clinical pharmacology. You never know who might have a lead on your dream job!
✨Show Off Your Skills
When you get the chance to chat with potential employers, make sure to highlight your hands-on experience with PK analysis and modelling. Share specific examples of how you've tackled challenges in past projects to demonstrate your expertise.
✨Tailor Your Approach
Before any interview, do your homework on the company and the role. Be ready to discuss how your background in PBPK/PD modelling aligns with their needs. This shows you're genuinely interested and prepared!
✨Apply Through Our Website
Don't forget to check out our website for open positions! Applying directly through us not only streamlines the process but also gives you a better chance of being noticed by hiring managers.
We think you need these skills to ace Principal Clinical Pharmacologist, PBPK/PD Modelling in Wolverhampton
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to highlight your experience in clinical pharmacology and modelling. We want to see how your skills align with the role, so don’t be shy about showcasing your hands-on PK analysis and PBPK modelling experience!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you’re passionate about this role and how your background makes you the perfect fit. Remember, we love seeing candidates who can translate complex analyses into clear conclusions.
Showcase Your Technical Skills:Don’t forget to highlight your technical skills, especially with tools like Phoenix WinNonlin and Simulations Plus GastroPlus. We’re looking for someone who can hit the ground running, so make sure we know what you bring to the table!
Apply Through Our Website:We encourage you to apply through our website for a smoother application process. It’s the best way for us to keep track of your application and ensure it gets the attention it deserves. Good luck!
How to prepare for a job interview at The RFT Group
✨Know Your Stuff
Make sure you brush up on your PK analysis and PBPK modelling skills. Be ready to discuss specific tools like Phoenix WinNonlin and Simulations Plus GastroPlus, as well as your experience with R or Python. The more you can demonstrate your technical expertise, the better!
✨Showcase Your Collaboration Skills
This role involves working closely with various teams, so be prepared to share examples of how you've successfully collaborated in the past. Highlight any experiences where you integrated insights from different disciplines to support development decisions.
✨Prepare for Technical Questions
Expect to face some challenging technical questions during the interview. Review common scenarios related to population PK/PD modelling and be ready to explain your thought process in analysing complex datasets. Practice articulating your approach clearly and confidently.
✨Communicate Clearly
Since you'll need to present results to cross-functional teams, focus on how you communicate complex information. Prepare a few examples of how you've effectively conveyed technical findings to non-technical audiences, ensuring they understand the implications for clinical development.
