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- Tasks: Lead clinical pharmacology projects and perform advanced modelling and analysis.
- Company: Join a dynamic biotech company focused on innovative drug development.
- Benefits: Competitive salary, professional growth, and collaborative work environment.
- Other info: Fast-paced environment with opportunities for career advancement.
- Why this job: Make a real impact in drug development with cutting-edge modelling techniques.
- Qualifications: PhD or MSc in life sciences, plus 5+ years in clinical development.
The predicted salary is between 60000 - 80000 £ per year.
Our client, a Biotech company, now seeks a Clinical Pharmacologist with a strong quantitative background to support clinical development through clinical pharmacology, modelling & simulation, and pharmacokinetic analysis. The role is primarily technical and execution-focused, with responsibility for study-level delivery across all phases including PK analysis, PBPK and population PK/PD modelling, for the interpretation of clinical and nonclinical data, preparation of clinical pharmacology deliverables, and presentation of results in cross-functional settings. The role requires close collaboration with Clinical Operations, Biostatistics, Regulatory, CMC, Toxicology, and Non-clinical, and the ability to translate quantitative analyses into clear, development-relevant conclusions. This position requires scientific leadership, independence, and accountability for high-quality outputs, while working in a fast-paced environment.
Responsibilities:
- Provide hands-on PK analysis and modelling support for clinical studies (Phase 1–3), including noncompartmental analysis, population PK/PD modelling, and PBPK modelling, as appropriate.
- Develop, implement, maintain, and interpret PBPK and population PK/PD models to support dose selection, study design, device/formulation bridging, special populations, and regulatory questions.
- Contribute to the design, analysis, interpretation, and reporting of clinical pharmacology components of clinical studies, under the direction of the Head of Clinical Pharmacology.
- Author and/or contribute to high-quality clinical pharmacology deliverables, including study reports or sections thereof, protocols, investigator brochures, modelling reports, and responses to regulatory questions.
- Integrate clinical pharmacology and pharmacometrics insights with nonclinical PK/ADME, clinical safety, and efficacy data to support development decisions.
- Support cross-functional teams by presenting analyses and modelling results at study team meetings, internal governance forums, and selected external interactions.
- Collaborate effectively with Clinical Operations, Biostatistics, and external vendors/CROs to ensure appropriate data flow, analysis standards, and timelines.
- Critically evaluate data quality, assumptions, and limitations in PK and modelling analyses, and clearly communicate uncertainty and impact on development decisions.
Requirements:
- BSc in Life Science, plus Post-graduate qualification (i.e. PhD or MSc) in a relevant life sciences or quantitative discipline (e.g. clinical pharmacology, pharmacometrics, pharmaceutical sciences, biomedical, or similar).
- 5+ years of experience in pharmaceutical, biotechnology, and/or CRO environments, with hands-on involvement in clinical development programs.
- Hands-on PK analysis experience using Phoenix WinNonlin.
- Hands-on PBPK modelling experience using tools such as Simulations Plus GastroPlus, SimCYP and/or PK-Sim/MoBi, including model development, verification, and interpretation.
- Experience using R (RStudio) and/or Python for data handling, analysis, and visualization.
- Preference for population PK/PD modelling experience using Phoenix NLME, including model development and application.
- Demonstrated ability to analyse complex datasets, build and interpret models, and communicate results clearly and practically to multidisciplinary audiences.
- Willing to expand into adjacent areas (e.g. DMPK, TK, clinical trial operational support) as required by program needs.
For further details, please contact Larry on +353 1 – 2302400.
Principal Clinical Pharmacologist, PBPK/PD Modelling in Shrewsbury employer: The RFT Group
Contact Detail:
The RFT Group Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Principal Clinical Pharmacologist, PBPK/PD Modelling in Shrewsbury
✨Tip Number 1
Network like a pro! Reach out to your connections in the biotech and pharmaceutical sectors. Attend industry events or webinars, and don’t be shy about introducing yourself. You never know who might have the inside scoop on job openings!
✨Tip Number 2
Prepare for interviews by brushing up on your technical skills. Since this role is all about PK analysis and modelling, make sure you can confidently discuss your experience with tools like Phoenix WinNonlin and Simulations Plus. Practice explaining complex concepts in simple terms.
✨Tip Number 3
Showcase your collaborative spirit! This role requires working closely with various teams, so be ready to share examples of how you've successfully collaborated in the past. Highlight your ability to communicate insights clearly across different functions.
✨Tip Number 4
Don’t forget to apply through our website! We’ve got loads of opportunities that might just be the perfect fit for you. Plus, it’s a great way to ensure your application gets seen by the right people.
We think you need these skills to ace Principal Clinical Pharmacologist, PBPK/PD Modelling in Shrewsbury
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to highlight your experience in clinical pharmacology and modelling. We want to see how your skills align with the role, so don’t be shy about showcasing your hands-on PK analysis and PBPK modelling experience!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you’re passionate about this role and how your background makes you the perfect fit. We love seeing enthusiasm and a clear understanding of the position.
Showcase Your Technical Skills: Don’t forget to mention your technical skills, especially with tools like Phoenix WinNonlin and Simulations Plus GastroPlus. We’re looking for someone who can hit the ground running, so highlight any relevant software experience you have!
Apply Through Our Website: We encourage you to apply through our website for a smoother application process. It helps us keep everything organised and ensures your application gets the attention it deserves. Let’s get started on this journey together!
How to prepare for a job interview at The RFT Group
✨Know Your PK and PBPK Inside Out
Make sure you brush up on your pharmacokinetics (PK) and physiologically-based pharmacokinetic (PBPK) modelling knowledge. Be prepared to discuss specific examples from your past experience where you've applied these concepts in clinical studies, as this will show your technical expertise and relevance to the role.
✨Showcase Your Collaboration Skills
Since the role involves working closely with various teams like Clinical Operations and Biostatistics, think of examples that highlight your ability to collaborate effectively. Prepare to share how you've successfully integrated insights from different disciplines to drive project outcomes.
✨Prepare for Technical Questions
Expect to face technical questions related to your hands-on experience with tools like Phoenix WinNonlin or Simulations Plus GastroPlus. Practise explaining your modelling processes and the rationale behind your analyses, as this will demonstrate your depth of knowledge and problem-solving skills.
✨Communicate Clearly and Confidently
You’ll need to present complex data and results to multidisciplinary audiences, so practice articulating your findings in a clear and concise manner. Use simple language to explain your analyses and conclusions, ensuring that even those without a technical background can understand your insights.