At a Glance
- Tasks: Lead clinical pharmacology projects and perform advanced modelling and analysis.
- Company: Dynamic biotech company focused on innovative drug development.
- Benefits: Competitive salary, flexible working options, and opportunities for professional growth.
- Other info: Collaborative environment with a focus on scientific leadership and innovation.
- Why this job: Make a real impact in drug development with cutting-edge modelling techniques.
- Qualifications: PhD or MSc in life sciences, plus 5+ years in clinical development.
The predicted salary is between 60000 - 80000 € per year.
Our client, a Biotech company, now seeks a Clinical Pharmacologist with a strong quantitative background to support clinical development through clinical pharmacology, modelling & simulation, and pharmacokinetic analysis. The role is primarily technical and execution-focused, with responsibility for study-level delivery across all phases including PK analysis, PBPK and population PK/PD modelling, for the interpretation of clinical and nonclinical data, preparation of clinical pharmacology deliverables, and presentation of results in cross-functional settings.
The role requires close collaboration with Clinical Operations, Biostatistics, Regulatory, CMC, Toxicology, and Non-clinical, and the ability to translate quantitative analyses into clear, development-relevant conclusions. This position requires scientific leadership, independence, and accountability for high-quality outputs, while working in a fast-paced environment.
Responsibilities:- Provide hands-on PK analysis and modelling support for clinical studies (Phase 1–3), including noncompartmental analysis, population PK/PD modelling, and PBPK modelling, as appropriate.
- Develop, implement, maintain, and interpret PBPK and population PK/PD models to support dose selection, study design, device/formulation bridging, special populations, and regulatory questions.
- Contribute to the design, analysis, interpretation, and reporting of clinical pharmacology components of clinical studies, under the direction of the Head of Clinical Pharmacology.
- Author and/or contribute to high-quality clinical pharmacology deliverables, including study reports or sections thereof, protocols, investigator brochures, modelling reports, and responses to regulatory questions.
- Integrate clinical pharmacology and pharmacometrics insights with nonclinical PK/ADME, clinical safety, and efficacy data to support development decisions.
- Support cross-functional teams by presenting analyses and modelling results at study team meetings, internal governance forums, and selected external interactions.
- Collaborate effectively with Clinical Operations, Biostatistics, and external vendors/CROs to ensure appropriate data flow, analysis standards, and timelines.
- Critically evaluate data quality, assumptions, and limitations in PK and modelling analyses, and clearly communicate uncertainty and impact on development decisions.
- BSc in Life Science, plus Post-graduate qualification (i.e. PhD or MSc) in a relevant life sciences or quantitative discipline (e.g. clinical pharmacology, pharmacometrics, pharmaceutical sciences, biomedical, or similar).
- 5+ years of experience in pharmaceutical, biotechnology, and/or CRO environments, with hands-on involvement in clinical development programs.
- Hands-on PK analysis experience using Phoenix WinNonlin.
- Hands-on PBPK modelling experience using tools such as Simulations Plus GastroPlus, SimCYP and/or PK-Sim/MoBi, including model development, verification, and interpretation.
- Experience using R (RStudio) and/or Python for data handling, analysis, and visualization.
- Preference for population PK/PD modelling experience using Phoenix NLME, including model development and application.
- Demonstrated ability to analyse complex datasets, build and interpret models, and communicate results clearly and practically to multidisciplinary audiences.
- Willing to expand into adjacent areas (e.g. DMPK, TK, clinical trial operational support) as required by program needs.
Principal Clinical Pharmacologist, PBPK/PD Modelling employer: The RFT Group
As a leading Biotech company, we pride ourselves on fostering a collaborative and innovative work environment that empowers our employees to excel in their roles. With a strong focus on professional development, we offer numerous opportunities for growth and advancement, alongside competitive benefits that support work-life balance. Join us in our fast-paced setting where your expertise in clinical pharmacology will directly contribute to groundbreaking advancements in healthcare.
StudySmarter Expert Advice🤫
We think this is how you could land Principal Clinical Pharmacologist, PBPK/PD Modelling
✨Tip Number 1
Network like a pro! Reach out to your connections in the biotech and pharmaceutical sectors. Attend industry events or webinars, and don’t be shy about introducing yourself. You never know who might have the inside scoop on job openings!
✨Tip Number 2
Prepare for interviews by brushing up on your technical skills. Since this role is all about PK analysis and modelling, make sure you can confidently discuss your experience with tools like Phoenix WinNonlin and Simulations Plus. Practice explaining complex concepts in simple terms.
✨Tip Number 3
Showcase your collaborative spirit! This role involves working closely with various teams, so be ready to share examples of how you've successfully collaborated in the past. Highlight your ability to communicate insights clearly across different functions.
✨Tip Number 4
Don’t forget to apply through our website! We’ve got loads of opportunities that might just be the perfect fit for you. Plus, it’s a great way to ensure your application gets seen by the right people. Let’s get you that dream job!
We think you need these skills to ace Principal Clinical Pharmacologist, PBPK/PD Modelling
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to highlight your experience in clinical pharmacology and modelling. We want to see how your skills align with the role, so don’t be shy about showcasing your hands-on PK analysis and PBPK modelling experience!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you’re passionate about this role and how your background makes you the perfect fit. Remember, we love seeing enthusiasm for the biotech field!
Showcase Your Technical Skills:Don’t forget to mention your technical skills, especially with tools like Phoenix WinNonlin and Simulations Plus. We’re looking for someone who can hit the ground running, so let us know what you bring to the table!
Apply Through Our Website:We encourage you to apply through our website for a smoother application process. It’s the best way for us to keep track of your application and ensure it gets the attention it deserves!
How to prepare for a job interview at The RFT Group
✨Know Your Models Inside Out
Make sure you’re well-versed in PBPK and population PK/PD modelling. Be ready to discuss your hands-on experience with tools like Simulations Plus GastroPlus or Phoenix NLME. Prepare to explain how you've applied these models in past projects, as this will show your technical expertise.
✨Showcase Your Collaborative Spirit
This role requires close collaboration with various teams. Think of examples where you’ve worked cross-functionally, especially with Clinical Operations or Biostatistics. Highlight how you communicated complex data insights to non-specialists, as this will demonstrate your ability to translate quantitative analyses into actionable conclusions.
✨Prepare for Technical Questions
Expect questions that dive deep into PK analysis and modelling. Brush up on your knowledge of noncompartmental analysis and be prepared to discuss how you evaluate data quality and assumptions. Practising answers to potential technical scenarios can help you feel more confident during the interview.
✨Communicate Clearly and Confidently
Since you'll need to present results in cross-functional settings, practice articulating your findings clearly. Use simple language to explain complex concepts, and prepare a few key points about your previous work that you can share succinctly. This will help you make a strong impression on the interviewers.
