At a Glance
- Tasks: Lead clinical pharmacology projects and perform advanced modelling and analysis.
- Company: Dynamic biotech company focused on innovative drug development.
- Benefits: Competitive salary, professional growth, and collaborative work environment.
- Other info: Join a fast-paced team with opportunities for career advancement.
- Why this job: Make a real impact in drug development with cutting-edge modelling techniques.
- Qualifications: PhD or MSc in life sciences, plus 5+ years in clinical development.
The predicted salary is between 60000 - 80000 £ per year.
Our client, a Biotech company, now seeks a Clinical Pharmacologist with a strong quantitative background to support clinical development through clinical pharmacology, modelling & simulation, and pharmacokinetic analysis. The role is primarily technical and execution‐focused, with responsibility for study‐level delivery across all phases including PK analysis, PBPK and population PK/PD modelling, for the interpretation of clinical and nonclinical data, preparation of clinical pharmacology deliverables, and presentation of results in cross‐functional settings. The role requires close collaboration with Clinical Operations, Biostatistics, Regulatory, CMC, Toxicology, and Non‐clinical, and the ability to translate quantitative analyses into clear, development‐relevant conclusions. This position requires scientific leadership, independence, and accountability for high‐quality outputs, while working in a fast-paced environment.
Responsibilities:
- Provide hands‐on PK analysis and modelling support for clinical studies (Phase 1–3), including noncompartmental analysis, population PK/PD modelling, and PBPK modelling, as appropriate.
- Develop, implement, maintain, and interpret PBPK and population PK/PD models to support dose selection, study design, device/formulation bridging, special populations, and regulatory questions.
- Contribute to the design, analysis, interpretation, and reporting of clinical pharmacology components of clinical studies, under the direction of the Head of Clinical Pharmacology.
- Author and/or contribute to high‐quality clinical pharmacology deliverables, including study reports or sections thereof, protocols, investigator brochures, modelling reports, and responses to regulatory questions.
- Integrate clinical pharmacology and pharmacometrics insights with nonclinical PK/ADME, clinical safety, and efficacy data to support development decisions.
- Support cross‐functional teams by presenting analyses and modelling results at study team meetings, internal governance forums, and selected external interactions.
- Collaborate effectively with Clinical Operations, Biostatistics, and external vendors/CROs to ensure appropriate data flow, analysis standards, and timelines.
- Critically evaluate data quality, assumptions, and limitations in PK and modelling analyses, and clearly communicate uncertainty and impact on development decisions.
Requirements:
- BSc in Life Science, plus Post‐graduate qualification (i.e. PhD or MSc) in a relevant life sciences or quantitative discipline (e.g. clinical pharmacology, pharmacometrics, pharmaceutical sciences, biomedical, or similar).
- 5+ years of experience in pharmaceutical, biotechnology, and/or CRO environments, with hands‐on involvement in clinical development programs.
- Hands‐on PK analysis experience using Phoenix WinNonlin.
- Hands‐on PBPK modelling experience using tools such as Simulations Plus GastroPlus, SimCYP and/or PK‐Sim/MoBi, including model development, verification, and interpretation.
- Experience using R (RStudio) and/or Python for data handling, analysis, and visualization.
- Preference for population PK/PD modelling experience using Phoenix NLME, including model development and application.
- Demonstrated ability to analyse complex datasets, build and interpret models, and communicate results clearly and practically to multidisciplinary audiences.
- Willing to expand into adjacent areas (e.g. DMPK, TK, clinical trial operational support) as required by program needs.
Principal Clinical Pharmacologist, PBPK/PD Modelling in Milton Keynes employer: The RFT Group
Join a leading Biotech company that values innovation and collaboration, offering a dynamic work environment where your expertise in clinical pharmacology and modelling will directly impact the development of life-changing therapies. With a strong commitment to employee growth, you will have access to continuous learning opportunities and the chance to work alongside cross-functional teams, ensuring your contributions are recognised and valued. Located in a vibrant area, this role not only promises professional fulfilment but also a supportive culture that prioritises work-life balance and employee well-being.
StudySmarter Expert Advice🤫
We think this is how you could land Principal Clinical Pharmacologist, PBPK/PD Modelling in Milton Keynes
✨Network Like a Pro
Get out there and connect with people in the industry! Attend conferences, webinars, or local meetups related to clinical pharmacology. You never know who might have a lead on your dream job or can introduce you to someone who does.
✨Show Off Your Skills
When you get the chance to chat with potential employers, make sure to highlight your hands-on experience with PK analysis and modelling. Share specific examples of how you've tackled challenges in past projects to demonstrate your expertise.
✨Tailor Your Approach
Before any interview, do your homework on the company and the role. Understand their current projects and challenges in PBPK/PD modelling. This way, you can tailor your responses to show how you can add value to their team.
✨Apply Through Our Website
Don’t forget to check out our website for open positions! Applying directly through us not only streamlines the process but also shows your commitment to joining our team. Let’s get you that Principal Clinical Pharmacologist role!
We think you need these skills to ace Principal Clinical Pharmacologist, PBPK/PD Modelling in Milton Keynes
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the role of Principal Clinical Pharmacologist. Highlight your quantitative background and any relevant experience in PK analysis and modelling. We want to see how your skills align with what we're looking for!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you're passionate about clinical pharmacology and how your experience makes you a great fit for our team. Keep it concise but impactful, and don’t forget to mention your hands-on experience with PBPK modelling.
Showcase Your Technical Skills:In your application, be sure to highlight your technical skills, especially in tools like Phoenix WinNonlin and Simulations Plus GastroPlus. We love seeing candidates who can demonstrate their ability to analyse complex datasets and communicate results effectively.
Apply Through Our Website:We encourage you to apply through our website for a smoother application process. It helps us keep track of your application and ensures you don’t miss out on any important updates. Plus, it’s super easy!
How to prepare for a job interview at The RFT Group
✨Know Your Models Inside Out
Make sure you’re well-versed in PBPK and population PK/PD modelling. Be ready to discuss your hands-on experience with tools like Simulations Plus GastroPlus or Phoenix NLME. Prepare to explain how you've applied these models in past projects, as this will show your technical expertise.
✨Prepare for Cross-Functional Collaboration
Since the role involves working closely with various teams, think of examples where you’ve successfully collaborated with Clinical Operations, Biostatistics, or Regulatory teams. Highlight your ability to communicate complex data clearly to different audiences, as this is crucial for the position.
✨Showcase Your Analytical Skills
Be prepared to discuss how you critically evaluate data quality and assumptions in your analyses. Bring examples of how you’ve communicated uncertainty and its impact on development decisions. This will demonstrate your scientific leadership and accountability.
✨Stay Current with Industry Trends
Familiarise yourself with the latest trends in clinical pharmacology and modelling. Being able to discuss recent advancements or regulatory changes can set you apart. It shows that you’re not just knowledgeable but also passionate about the field.
