At a Glance
- Tasks: Lead clinical pharmacology projects and perform advanced modelling and analysis.
- Company: Dynamic biotech company focused on innovative drug development.
- Benefits: Competitive salary, flexible working options, and opportunities for professional growth.
- Other info: Collaborative environment with a focus on scientific leadership and innovation.
- Why this job: Make a real impact in drug development with cutting-edge modelling techniques.
- Qualifications: PhD or MSc in life sciences, plus 5+ years in clinical development.
The predicted salary is between 60000 - 80000 € per year.
Our client, a Biotech company, now seeks a Clinical Pharmacologist with a strong quantitative background to support clinical development through clinical pharmacology, modelling & simulation, and pharmacokinetic analysis. The role is primarily technical and execution-focused, with responsibility for study-level delivery across all phases including PK analysis, PBPK and population PK/PD modelling, for the interpretation of clinical and nonclinical data, preparation of clinical pharmacology deliverables, and presentation of results in cross-functional settings.
The role requires close collaboration with Clinical Operations, Biostatistics, Regulatory, CMC, Toxicology, and Non-clinical, and the ability to translate quantitative analyses into clear, development-relevant conclusions. This position requires scientific leadership, independence, and accountability for high-quality outputs, while working in a fast-paced environment.
Responsibilities:
- Provide hands-on PK analysis and modelling support for clinical studies (Phase 1–3), including noncompartmental analysis, population PK/PD modelling, and PBPK modelling, as appropriate.
- Develop, implement, maintain, and interpret PBPK and population PK/PD models to support dose selection, study design, device/formulation bridging, special populations, and regulatory questions.
- Contribute to the design, analysis, interpretation, and reporting of clinical pharmacology components of clinical studies, under the direction of the Head of Clinical Pharmacology.
- Author and/or contribute to high-quality clinical pharmacology deliverables, including study reports or sections thereof, protocols, investigator brochures, modelling reports, and responses to regulatory questions.
- Integrate clinical pharmacology and pharmacometrics insights with nonclinical PK/ADME, clinical safety, and efficacy data to support development decisions.
- Support cross-functional teams by presenting analyses and modelling results at study team meetings, internal governance forums, and selected external interactions.
- Collaborate effectively with Clinical Operations, Biostatistics, and external vendors/CROs to ensure appropriate data flow, analysis standards, and timelines.
- Critically evaluate data quality, assumptions, and limitations in PK and modelling analyses, and clearly communicate uncertainty and impact on development decisions.
Requirements:
- BSc in Life Science, plus Post-graduate qualification (i.e. PhD or MSc) in a relevant life sciences or quantitative discipline (e.g. clinical pharmacology, pharmacometrics, pharmaceutical sciences, biomedical, or similar).
- 5+ years of experience in pharmaceutical, biotechnology, and/or CRO environments, with hands-on involvement in clinical development programs.
- Hands-on PK analysis experience using Phoenix WinNonlin.
- Hands-on PBPK modelling experience using tools such as Simulations Plus GastroPlus, SimCYP and/or PK-Sim/MoBi, including model development, verification, and interpretation.
- Experience using R (RStudio) and/or Python for data handling, analysis, and visualization.
- Preference for population PK/PD modelling experience using Phoenix NLME, including model development and application.
- Demonstrated ability to analyse complex datasets, build and interpret models, and communicate results clearly and practically to multidisciplinary audiences.
- Willing to expand into adjacent areas (e.g. DMPK, TK, clinical trial operational support) as required by program needs.
Principal Clinical Pharmacologist, PBPK/PD Modelling in Manchester employer: The RFT Group
Join a leading Biotech company that prioritises innovation and collaboration, offering a dynamic work environment where your expertise in clinical pharmacology and modelling will directly impact the development of life-changing therapies. With a strong commitment to employee growth, you will have access to continuous learning opportunities and the chance to work alongside cross-functional teams, fostering a culture of scientific excellence and accountability. Located in a vibrant area, this role not only promises meaningful work but also a supportive atmosphere that values your contributions and encourages professional advancement.
StudySmarter Expert Advice🤫
We think this is how you could land Principal Clinical Pharmacologist, PBPK/PD Modelling in Manchester
✨Network Like a Pro
Get out there and connect with people in the industry! Attend conferences, webinars, or local meetups related to clinical pharmacology. You never know who might have the inside scoop on job openings or can refer you directly to hiring managers.
✨Show Off Your Skills
When you land an interview, be ready to showcase your hands-on experience with PK analysis and modelling. Bring examples of your work, like reports or models you've developed, to demonstrate your expertise and how you can contribute to their team.
✨Tailor Your Approach
Make sure to tailor your discussions during interviews to highlight your experience with PBPK and population PK/PD modelling. Use specific examples that relate to the role and show how your skills align with their needs.
✨Apply Through Our Website
Don’t forget to check out our website for the latest job openings! Applying through our platform not only keeps you updated but also gives you a better chance of being noticed by recruiters who are looking for candidates just like you.
We think you need these skills to ace Principal Clinical Pharmacologist, PBPK/PD Modelling in Manchester
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to highlight your experience in clinical pharmacology and modelling. We want to see how your skills align with the role, so don’t be shy about showcasing your hands-on PK analysis and PBPK modelling experience!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you’re passionate about this role and how your background makes you the perfect fit. We love seeing enthusiasm and a clear understanding of the position.
Showcase Your Technical Skills:Don’t forget to mention your technical skills, especially with tools like Phoenix WinNonlin and Simulations Plus. We’re looking for someone who can hit the ground running, so let us know how you’ve used these tools in your previous roles.
Apply Through Our Website:We encourage you to apply through our website for a smoother application process. It helps us keep everything organised and ensures your application gets the attention it deserves. Good luck!
How to prepare for a job interview at The RFT Group
✨Know Your PK and PBPK Inside Out
Make sure you brush up on your pharmacokinetics (PK) and physiologically-based pharmacokinetic (PBPK) modelling knowledge. Be prepared to discuss specific examples of how you've applied these concepts in previous roles, especially using tools like Phoenix WinNonlin or Simulations Plus GastroPlus.
✨Showcase Your Collaboration Skills
This role requires close collaboration with various teams. Think of examples where you've successfully worked with cross-functional teams, such as Clinical Operations or Biostatistics. Highlight how you communicated complex data and findings to non-experts.
✨Prepare for Technical Questions
Expect technical questions related to population PK/PD modelling and data analysis. Review your experience with R or Python for data handling and be ready to explain your approach to model development and interpretation clearly.
✨Demonstrate Leadership and Accountability
The position calls for scientific leadership and accountability. Prepare to discuss instances where you've taken the lead on projects or analyses, ensuring high-quality outputs. Show that you can work independently while still being a team player.
