Principal Clinical Pharmacometrician in Ipswich

Our client, a Biotech company, now seeks a Clinical Pharmacologist with a strong quantitative background to support clinical development through clinical pharmacology, modelling & simulation, and pharmacokinetic analysis. This is a 12 month fixed term contract role and this hire must be resident in the UK.

The role is primarily technical and execution-focused, with responsibility for study-level delivery across all phases including PK analysis, PBPK and population PK/PD modelling, for the interpretation of clinical and nonclinical data, preparation of clinical pharmacology deliverables, and presentation of results in cross-functional settings. The role requires close collaboration with Clinical Operations, Biostatistics, Regulatory, CMC, Toxicology, and Non-clinical, and the ability to translate quantitative analyses into clear, development-relevant conclusions. This position requires scientific leadership, independence, and accountability for high-quality outputs, while working in a fast-paced environment.

Responsibilities:

• Provide hands-on PK analysis and modelling support for clinical studies (Phase 1–3), including noncompartmental analysis, population PK/PD modelling, and PBPK modelling, as appropriate.
• Develop, implement, maintain, and interpret PBPK and population PK/PD models to support dose selection, study design, device/formulation bridging, special populations, and regulatory questions.
• Contribute to the design, analysis, interpretation, and reporting of clinical pharmacology components of clinical studies, under the direction of the Head of Clinical Pharmacology.
• Author and/or contribute to high-quality clinical pharmacology deliverables, including study reports or sections thereof, protocols, investigator brochures, modelling reports, and responses to regulatory questions.
• Integrate clinical pharmacology and pharmacometrics insights with nonclinical PK/ADME, clinical safety, and efficacy data to support development decisions.
• Support cross-functional teams by presenting analyses and modelling results at study team meetings, internal governance forums, and selected external interactions.
• Collaborate effectively with Clinical Operations, Biostatistics, and external vendors/CROs to ensure appropriate data flow, analysis standards, and timelines.
• Critically evaluate data quality, assumptions, and limitations in PK and modelling analyses, and clearly communicate uncertainty and impact on development decisions.

Requirements:

• BSc in Life Science, plus Post-graduate qualification (i.e. PhD or MSc) in a relevant life sciences or quantitative discipline (e.g. clinical pharmacology, pharmacometrics, pharmaceutical sciences, biomedical, or similar).
• 5+ years of experience in pharmaceutical, biotechnology, and/or CRO environments, with hands-on involvement in clinical development programs.
• Hands-on PK analysis experience using Phoenix WinNonlin.
• Hands-on PBPK modelling experience using tools such as Simulations Plus GastroPlus, SimCYP and/or PK-Sim/MoBi, including model development, verification, and interpretation.
• Experience using R (RStudio) and/or Python for data handling, analysis, and visualization.
• Preference for population PK/PD modelling experience using Phoenix NLME, including model development and application.
• Demonstrated ability to analyse complex datasets, build and interpret models, and communicate results clearly and practically to multidisciplinary audiences.
• Willing to expand into adjacent areas (e.g. DMPK, TK, clinical trial operational support) as required by program needs.