At a Glance
- Tasks: Lead clinical pharmacology projects and perform advanced PK analysis and modelling.
- Company: Dynamic biotech company focused on innovative drug development.
- Benefits: 12-month contract with competitive pay and opportunities for professional growth.
- Other info: Fast-paced environment with opportunities to expand your skill set.
- Why this job: Make a real impact in drug development while collaborating with top industry experts.
- Qualifications: BSc in Life Science plus postgraduate qualification; 5+ years in pharma or biotech.
The predicted salary is between 60000 - 80000 £ per year.
Our client, a Biotech company, now seeks a Clinical Pharmacologist with a strong quantitative background to support clinical development through clinical pharmacology, modelling & simulation, and pharmacokinetic analysis. This is a 12 month fixed term contract role and this hire must be resident in the UK.
The role is primarily technical and execution‐focused, with responsibility for study‐level delivery across all phases including PK analysis, PBPK and population PK/PD modelling, for the interpretation of clinical and nonclinical data, preparation of clinical pharmacology deliverables, and presentation of results in cross‐functional settings.
The role requires close collaboration with Clinical Operations, Biostatistics, Regulatory, CMC, Toxicology, and Non‐clinical, and the ability to translate quantitative analyses into clear, development‐relevant conclusions. This position requires scientific leadership, independence, and accountability for high‐quality outputs, while working in a fast-paced environment.
Responsibilities:- Provide hands‐on PK analysis and modelling support for clinical studies (Phase 1–3), including noncompartmental analysis, population PK/PD modelling, and PBPK modelling, as appropriate.
- Develop, implement, maintain, and interpret PBPK and population PK/PD models to support dose selection, study design, device/formulation bridging, special populations, and regulatory questions.
- Contribute to the design, analysis, interpretation, and reporting of clinical pharmacology components of clinical studies, under the direction of the Head of Clinical Pharmacology.
- Author and/or contribute to high‐quality clinical pharmacology deliverables, including study reports or sections thereof, protocols, investigator brochures, modelling reports, and responses to regulatory questions.
- Integrate clinical pharmacology and pharmacometrics insights with nonclinical PK/ADME, clinical safety, and efficacy data to support development decisions.
- Support cross‐functional teams by presenting analyses and modelling results at study team meetings, internal governance forums, and selected external interactions.
- Collaborate effectively with Clinical Operations, Biostatistics, and external vendors/CROs to ensure appropriate data flow, analysis standards, and timelines.
- Critically evaluate data quality, assumptions, and limitations in PK and modelling analyses, and clearly communicate uncertainty and impact on development decisions.
- BSc in Life Science, plus Post‐graduate qualification (i.e. PhD or MSc) in a relevant life sciences or quantitative discipline (e.g. clinical pharmacology, pharmacometrics, pharmaceutical sciences, biomedical, or similar).
- 5+ years of experience in pharmaceutical, biotechnology, and/or CRO environments, with hands‐on involvement in clinical development programs.
- Hands‐on PK analysis experience using Phoenix WinNonlin.
- Hands‐on PBPK modelling experience using tools such as Simulations Plus GastroPlus, SimCYP and/or PK‐Sim/MoBi, including model development, verification, and interpretation.
- Experience using R (RStudio) and/or Python for data handling, analysis, and visualization.
- Preference for population PK/PD modelling experience using Phoenix NLME, including model development and application.
- Demonstrated ability to analyse complex datasets, build and interpret models, and communicate results clearly and practically to multidisciplinary audiences.
- Willing to expand into adjacent areas (e.g. DMPK, TK, clinical trial operational support) as required by program needs.
Principal Clinical Pharmacometrician in High Wycombe employer: The RFT Group
As a leading Biotech company, we pride ourselves on fostering a collaborative and innovative work environment that empowers our employees to excel in their roles. With a strong focus on professional development, we offer numerous opportunities for growth and advancement, alongside competitive benefits tailored to support your well-being. Located in the UK, our dynamic team thrives on scientific leadership and independence, making it an ideal place for passionate individuals looking to make a meaningful impact in clinical pharmacology.
StudySmarter Expert Advice🤫
We think this is how you could land Principal Clinical Pharmacometrician in High Wycombe
✨Tip Number 1
Network like a pro! Reach out to your connections in the biotech and pharmaceutical sectors. Attend industry events or webinars, and don’t be shy about introducing yourself. You never know who might have the inside scoop on job openings!
✨Tip Number 2
Prepare for interviews by brushing up on your technical skills. Since this role is all about PK analysis and modelling, make sure you can confidently discuss your experience with tools like Phoenix WinNonlin and Simulations Plus. Practice explaining complex concepts in simple terms.
✨Tip Number 3
Showcase your collaborative spirit! This role requires working closely with various teams, so be ready to share examples of how you've successfully collaborated in the past. Highlight your ability to communicate insights clearly across different functions.
✨Tip Number 4
Don’t forget to apply through our website! We’ve got loads of opportunities that might just be the perfect fit for you. Plus, it’s a great way to ensure your application gets seen by the right people.
We think you need these skills to ace Principal Clinical Pharmacometrician in High Wycombe
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the Principal Clinical Pharmacometrician role. Highlight your relevant experience in PK analysis and modelling, and don’t forget to mention any specific tools you’ve used like Phoenix WinNonlin or Simulations Plus.
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you're the perfect fit for this role. Mention your quantitative background and how it aligns with the responsibilities outlined in the job description.
Showcase Your Collaboration Skills:Since this role involves working closely with various teams, make sure to highlight your collaboration skills. Share examples of how you've successfully worked with cross-functional teams in the past.
Apply Through Our Website:We encourage you to apply through our website for a smoother application process. It’s the best way for us to receive your application and get you on our radar!
How to prepare for a job interview at The RFT Group
✨Know Your PK Inside Out
Make sure you brush up on your pharmacokinetic analysis skills, especially using Phoenix WinNonlin. Be ready to discuss specific examples from your past experience where you've successfully applied these techniques in clinical studies.
✨Showcase Your Modelling Skills
Prepare to talk about your hands-on experience with PBPK modelling tools like Simulations Plus GastroPlus or SimCYP. Have a couple of case studies in mind that demonstrate how you developed and interpreted models to support dose selection or study design.
✨Communicate Clearly
Since the role involves presenting analyses to cross-functional teams, practice explaining complex data in simple terms. Think about how you can convey your findings to non-experts without losing the technical essence.
✨Collaborative Mindset
Be ready to discuss how you've worked with various teams, such as Clinical Operations and Biostatistics. Highlight any experiences where you facilitated data flow or ensured analysis standards were met, showcasing your ability to work in a fast-paced environment.
