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- Tasks: Conduct innovative research in bacteriophage engineering and test therapeutic applications.
- Company: The University of Sheffield, a leader in microbiology and genomics research.
- Benefits: Opportunity to publish research and contribute to groundbreaking phage therapy.
- Why this job: Join a dynamic team and make a real impact against antibiotic-resistant infections.
- Qualifications: PhD in Microbiology, Genomics, or related field; strong lab experience required.
- Other info: Collaborative environment with opportunities for independent research and career growth.
The predicted salary is between 36000 - 60000 £ per year.
The University of Sheffield is inviting applications for a self-funded PhD position in Bacteriophage Engineering aimed at developing novel therapeutic strategies to target antibiotic-resistant enterococci. The project focuses on using bacteriophages as precision tools for combating multi-drug-resistant pathogens, with an emphasis on engineering phages to expand their host range.
This project is ideal for individuals with a PhD or those nearing completion of their PhD in microbiology, genomics, or molecular biology, who are interested in applying their expertise to the emerging field of phage therapy. The successful candidate will have the opportunity to engage in cutting‑edge research, potentially leading to significant contributions in the fight against antibiotic-resistant infections.
The successful applicant will be part of a dynamic research team under the supervision of Dr. Stephane Mesnage and Prof. G. Stafford. The research will provide an excellent opportunity for independent work in the areas of bacteriology, bioinformatics, genomics, and microbiology. The research will focus on bacteriophage engineering and its potential as a therapeutic strategy against Vancomycin‑Resistant Enterococci (VRE), which are responsible for both hospital‑acquired and community infections.
The specific objectives of the project include:
- Characterizing receptor binding proteins of phages targeting enterococci and investigating the molecular mechanisms that enable these phages to recognize bacterial cell wall structures.
- Engineering recombinant phages to modify their host range using techniques such as golden gate assembly and error‑prone PCR.
- Testing the therapeutic potential of recombinant phages against planktonic cultures, biofilms, and in host‑pathogen interaction models, including zebrafish.
Key Responsibilities:
- Conduct independent and innovative research in bacteriophage engineering
- Characterize and modify phage receptor binding proteins
- Engineer phages with extended host ranges for therapeutic applications
- Test phage efficacy in both planktonic and biofilm cultures, and in zebrafish infection models
- Publish research findings in peer‑reviewed journals
Required Qualifications:
- A PhD in Microbiology, Genomics, Molecular Biology, or a related field (or be in the process of completing your PhD)
- Strong laboratory experience in bacteriology, molecular biology techniques, or phage biology
Required Skills:
- Experience in bacteriophage biology and protein engineering
- Strong analytical and bioinformatics skills
- Excellent written and verbal communication skills
- Ability to work independently and in a collaborative environment
PhD Project in Bacteriophage Engineering in Sheffield employer: The Phage
Contact Detail:
The Phage Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land PhD Project in Bacteriophage Engineering in Sheffield
✨Tip Number 1
Network like a pro! Reach out to your contacts in the microbiology and genomics fields. Attend conferences or seminars where you can meet researchers and professionals who might know about opportunities in bacteriophage engineering.
✨Tip Number 2
Show off your skills! Prepare a portfolio showcasing your research, publications, and any relevant projects. This will help you stand out when discussing your experience with potential supervisors or collaborators.
✨Tip Number 3
Be proactive! Don’t just wait for job postings. Reach out directly to labs or research groups that interest you, like Dr. Stephane Mesnage’s team. Express your enthusiasm for their work and inquire about potential openings.
✨Tip Number 4
Apply through our website! We’ve got loads of resources to help you land that PhD position. Make sure to check out our tips and tools to enhance your application process and increase your chances of success.
We think you need these skills to ace PhD Project in Bacteriophage Engineering in Sheffield
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your relevant experience in microbiology, genomics, or molecular biology. We want to see how your skills align with the exciting work we're doing in bacteriophage engineering!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Tell us why you're passionate about phage therapy and how your background makes you a perfect fit for this PhD project. Keep it engaging and personal!
Showcase Your Research Experience: We love seeing hands-on experience! Be sure to detail any independent research you've conducted, especially if it relates to bacteriology or phage biology. This will help us understand your capabilities.
Apply Through Our Website: Don't forget to submit your application through our website! It’s the easiest way for us to keep track of your application and ensures you don’t miss out on any important updates.
How to prepare for a job interview at The Phage
✨Know Your Phages
Make sure you brush up on your knowledge of bacteriophages and their role in combating antibiotic resistance. Be prepared to discuss recent advancements in phage therapy and how they relate to the project at The University of Sheffield.
✨Showcase Your Skills
Highlight your laboratory experience and any specific techniques you've mastered, especially in bacteriology and molecular biology. Be ready to provide examples of how you've applied these skills in previous research or projects.
✨Prepare for Technical Questions
Expect questions about engineering phages and modifying host ranges. Familiarise yourself with techniques like golden gate assembly and error-prone PCR, and be ready to explain how you would apply them in this research context.
✨Engage with the Team
Demonstrate your ability to work collaboratively by discussing how you’ve successfully worked in teams before. Mention any experiences where you contributed to a dynamic research environment, as this will resonate well with the supervisors.