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- Tasks: Advance research in molecular microbiology and structural biology using cryo-electron microscopy.
- Company: Imperial College London, a leading institution in life sciences research.
- Benefits: Gain hands-on experience in cutting-edge research with potential for impactful discoveries.
- Why this job: Join a pioneering project on gene transfer mechanisms and contribute to vital microbial evolution studies.
- Qualifications: PhD in structural biology or related field, with expertise in cryo-EM and protein biochemistry.
- Other info: Collaborative lab environment with opportunities for publishing and professional growth.
The predicted salary is between 36000 - 60000 £ per year.
The Imperial College London is inviting applications for a Research Associate position in the Department of Life Sciences. The position will be based in the laboratory of Tiago Dias da Costa and focuses on advancing research in molecular microbiology and structural biology. The project is funded by a Wellcome Trust Discovery Award and aims to uncover the molecular mechanisms underlying horizontal gene transfer (HGT) in bacteria. Horizontal gene transfer plays a crucial role in microbial evolution and the spread of antimicrobial resistance.
This project focuses on understanding two major mechanisms of HGT: Bacterial conjugation and Bacteriophage‑mediated transduction. The research will investigate the macromolecular nanomachines that enable these processes, with particular emphasis on the structural biology of conjugation systems and bacteriophages. The project builds on studying Type IV secretion systems and bacteriophage biology. The appointed researcher will primarily use cryo‑electron microscopy (cryo‑EM) to study the structural mechanisms of gene transfer systems.
The work will involve:
- Protein expression and purification
- Structural analysis of macromolecular complexes
- Cryo‑EM grid preparation and imaging
- Single‑particle analysis (SPA) data acquisition and processing
Qualifications & Skills Required
- PhD in structural biology or a related discipline
- Expertise in cryo‑electron microscopy
- Experience in protein biochemistry and molecular biology
- Demonstrated ability to perform end‑to‑end protein structure determination workflows
- Experience in single‑particle cryo‑EM data acquisition and processing
- At least one first‑author publication in an international peer‑reviewed journal or preprint
Research Associate Opportunity in Structural Biology employer: The Phage
Contact Detail:
The Phage Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Research Associate Opportunity in Structural Biology
✨Tip Number 1
Network like a pro! Reach out to your connections in the field of structural biology and microbiology. Attend relevant seminars or workshops, and don’t be shy about introducing yourself to researchers at events. You never know who might have a lead on a job opportunity!
✨Tip Number 2
Show off your skills! If you’ve got experience with cryo-EM or protein purification, make sure to highlight that in conversations. Bring along a portfolio of your work or any publications to showcase your expertise when chatting with potential employers.
✨Tip Number 3
Be proactive! Don’t just wait for job postings to appear. Reach out directly to labs or departments you’re interested in, like Tiago Dias da Costa’s lab at Imperial College London. Express your enthusiasm for their research and ask if they have any upcoming opportunities.
✨Tip Number 4
Apply through our website! We’ve got loads of exciting Research Associate positions listed, including those related to phage research. Make sure to check it out regularly and apply directly to increase your chances of landing that dream job!
We think you need these skills to ace Research Associate Opportunity in Structural Biology
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your relevant experience in structural biology and cryo-EM. We want to see how your skills align with the research focus on horizontal gene transfer, so don’t hold back on showcasing your expertise!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you’re passionate about this project and how your background makes you a perfect fit. We love seeing enthusiasm for molecular microbiology and structural biology.
Showcase Your Publications: If you’ve got a first-author publication, make sure to mention it! This is a great way to demonstrate your research capabilities. We’re keen to see how your previous work relates to the role and the exciting research we’re doing.
Apply Through Our Website: Don’t forget to submit your application through our website! It’s the easiest way for us to keep track of your application and ensures you’re considered for this fantastic opportunity at Imperial College London.
How to prepare for a job interview at The Phage
✨Know Your Stuff
Make sure you brush up on the latest research in structural biology and molecular microbiology. Familiarise yourself with horizontal gene transfer mechanisms, especially bacterial conjugation and bacteriophage-mediated transduction. Being able to discuss recent findings or papers will show your passion and expertise.
✨Showcase Your Skills
Prepare to talk about your experience with cryo-electron microscopy and protein biochemistry. Have specific examples ready that highlight your end-to-end workflows in protein structure determination. This is your chance to shine, so don’t hold back!
✨Ask Smart Questions
Think of insightful questions to ask during the interview. Inquire about the lab's current projects or future directions in their research. This not only shows your interest but also helps you gauge if the lab environment is the right fit for you.
✨Be Yourself
While it’s important to be professional, don’t forget to let your personality shine through. The interviewers want to see if you’ll fit into their team culture. Be genuine, enthusiastic, and confident in your abilities!