At a Glance
- Tasks: Investigate Wnt/β-catenin signalling using cutting-edge techniques like CRISPR and live-cell imaging.
- Company: Join the Institute of Cancer Research, a leading global cancer research institute.
- Benefits: Competitive salary, pension, professional development, and access to state-of-the-art facilities.
- Other info: Dynamic, supportive environment with a focus on diversity and inclusion.
- Why this job: Make a real impact in cancer research while collaborating with top experts in the field.
- Qualifications: PhD in biological science or related field; experience in molecular biology and cell biology required.
The predicted salary is between 36000 - 60000 £ per year.
Key Information
- Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review.
- This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application.
- Duration of Contract: Fixed Term for 3 years initially.
- Hours per week: 35 hours per week (Full Time).
- Location: Chelsea.
- Closing Date: 30 November 2025.
Job Details
Under the guidance of Professor Sebastian Guettler, we are seeking to recruit a Postdoctoral Training Fellow to investigate the molecular mechanisms of Wnt/β-catenin signalling, using a combination of mammalian genetics, cell biology, proteomics and biochemistry. The successful candidate will apply mammalian genetics (CRISPR), cellular biochemistry, proteomics and light microscopy (including live‑cell imaging) to investigate the mechanisms of Wnt/β-catenin signalling in normal physiology and cancer. The particular focus of the project will be on studying the molecular mechanisms underlying the activities and regulation of the β‑catenin destruction complex and its dysregulation in APC‑mutant cancers, particularly colorectal cancer. The position will offer a stimulating balance of independence and collaboration. The candidate will join a multidisciplinary, collaborative and international team with a core expertise in biochemistry, structural biology (electron microscopy, X‑ray crystallography), biophysics and genetics, and established collaborations in chemistry and proteomics.
About You
The successful candidate must have a PhD in a biological science or any other area relevant to the proposed research, and experience in contemporary molecular biology, mammalian genetics, cell biology and biochemistry. Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years.
Department/Directorate Information
Work in the Structural Biology of Cell Signalling Team, led by Professor Sebastian Guettler, in the ICR Divisions of Structural Biology and Cell and Molecular Biology, centres on the molecular mechanisms of Wnt/β-catenin signalling and telomere maintenance, both of which play key roles in stem cells and a wide range of cancers. A long‑standing interest of the team is to understand how ADP‑ribosylation, a complex and extremely versatile post‑translational modification, controls both these systems, and how the ADP‑ribosyltransferase tankyrase is regulated.
What We Offer
- A dynamic and supportive research environment
- Access to state‑of‑the‑art facilities and professional development opportunities
- Collaboration with leading researchers in the field
- Competitive salary and pension
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Sebastian Guettler via e‑mail.
About The Institute Of Cancer Research
The ICR is committed to supporting overseas applicants applying for roles. The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here. At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.
Postdoctoral Training Fellow - Biochemistry and Cell Biology of Wnt - β-catenin signalling employer: The Institute Of Cancer Research
The Institute of Cancer Research (ICR) is an exceptional employer, offering a dynamic and supportive research environment in Chelsea, where you can collaborate with leading researchers in the field of cancer biology. With access to state-of-the-art facilities, competitive salaries, and a strong commitment to professional development, the ICR fosters a culture of inclusivity and innovation, making it an ideal place for Postdoctoral Training Fellows to thrive and grow in their careers.
Contact Details:
The Institute Of Cancer Research Recruitment Team
StudySmarter Expert Advice🤫
We think this is how you could land Postdoctoral Training Fellow - Biochemistry and Cell Biology of Wnt - β-catenin signalling
✨Tip Number 1
Network like a pro! Reach out to your connections in the field of biochemistry and cell biology. Attend seminars, workshops, or conferences where you can meet potential collaborators or mentors who might help you land that postdoc position.
✨Tip Number 2
Prepare for interviews by brushing up on your knowledge of Wnt/β-catenin signalling. Be ready to discuss your previous research and how it relates to the role. We want to see your passion and expertise shine through!
✨Tip Number 3
Don’t hesitate to reach out for an informal chat with Professor Guettler or other team members. It’s a great way to show your interest and get insights about the team dynamics and ongoing projects.
✨Tip Number 4
Apply through our website! It’s the best way to ensure your application gets the attention it deserves. Plus, you’ll find all the details you need about the role and the ICR culture right there.
We think you need these skills to ace Postdoctoral Training Fellow - Biochemistry and Cell Biology of Wnt - β-catenin signalling
Some tips for your application 🫡
Tailor Your Application:Make sure to customise your CV and cover letter to highlight your relevant experience in biochemistry and cell biology. We want to see how your skills align with the Wnt/β-catenin signalling project, so don’t hold back!
Showcase Your Research Experience:When detailing your research background, focus on your PhD work and any hands-on experience with techniques like CRISPR, proteomics, or live-cell imaging. We’re keen to know how you’ve tackled similar challenges in the past.
Be Clear and Concise:Keep your application straightforward and to the point. Use clear language to describe your achievements and avoid jargon unless it’s necessary. We appreciate clarity as much as complexity!
Apply Through Our Website:Don’t forget to submit your application through our official website! It’s the best way for us to receive your details and ensures you’re considered for this exciting opportunity.
How to prepare for a job interview at The Institute Of Cancer Research
✨Know Your Wnt/β-catenin Signalling
Make sure you brush up on the specifics of Wnt/β-catenin signalling. Understand the molecular mechanisms involved, especially the β-catenin destruction complex and its role in cancer. Being able to discuss these topics confidently will show your genuine interest and expertise.
✨Showcase Your Technical Skills
Prepare to talk about your experience with mammalian genetics, CRISPR, and proteomics. Bring examples of your past work or projects that highlight your skills in cell biology and biochemistry. This is your chance to demonstrate how your background aligns with the role.
✨Emphasise Collaboration
This position involves working within a multidisciplinary team, so be ready to discuss your collaborative experiences. Share examples of how you've worked with others in research settings, and how you can contribute to a supportive and innovative environment.
✨Ask Insightful Questions
Prepare thoughtful questions about the research team's current projects or future directions. This not only shows your enthusiasm but also helps you gauge if the team’s goals align with your own. It’s a great way to engage with the interviewers and leave a lasting impression.
