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- Tasks: Join a cutting-edge lab to analyse complex biological data and drive cancer research.
- Company: The Francis Crick Institute, a leading biomedical discovery institute in London.
- Benefits: Competitive salary starting from £53,025, plus benefits and opportunities for professional growth.
- Why this job: Make a real impact in cancer research using advanced bioinformatics and machine learning.
- Qualifications: PhD in Computational Cancer Biology or equivalent, with experience in single-cell RNA sequencing.
- Other info: Collaborative environment with access to state-of-the-art facilities and resources.
The predicted salary is between 53025 - 60000 £ per year.
Location: The Francis Crick Institute, Midland Road, London, NW1 1AT
Dr Li’s laboratory investigates the functional implication of Wnt signalling pathway in intestinal stem cells, regeneration and cancer with emphasis on finding new tumour‑specific targets. Her lab combines genetically engineered mouse models, patient‑derived organoids, and advanced genomic tools to investigate how Wnt signalling and cell state plasticity contribute to homeostasis and disease, particularly in the context of therapy resistance in colorectal cancer. Details of research projects currently being undertaken can be seen at: https://www.crick.ac.uk/vivian-li/.
We are looking for an ambitious, collaborative and self‑motivated Senior Bioinformatician to work for Dr Li’s Stem Cell and Cancer Biology laboratory who can integrate functional CRISPR screens with single‑cell and spatial transcriptomics to uncover the mechanisms driving cell state rewiring and therapeutic resistance in cancer. This project is funded by CRUK Cancer Grand Challenges REWIRE‑CAN programme.
Key Responsibilities
- Work collaboratively across the Stem Cell and Cancer Biology laboratory to co‑design experiments, formulate analysis plans and interpret results.
- Perform standard and advanced analyses of high‑dimensional, data‑intensive and complex research questions across the biomedical research spectrum using bioinformatics, biostatistics, machine learning and AI approaches.
- Empower biologists to understand their datasets, using our broad training portfolio to enable data curiosity and develop analytical skills.
- Design innovative approaches for recurrent and novel projects, and deploy corresponding tools internally, across the Stem Cell and Cancer Biology laboratory and beyond.
About you
- PhD in Computational Cancer Biology or equivalent, or in the final stages of PhD submission.
- Evidence of applying computational/bioinformatic skill to address complex biological questions.
- Experience in single‑cell RNA sequencing and spatial transcriptomic data analysis.
- Strong track record of research as evidenced by publications in referred journals.
- Strong written and oral communication skills as evidenced by data presentation at scientific meetings.
- Experience in studying cellular plasticity using computational approach would be advantageous.
About us
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases. An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London. The Crick was formed in 2015, and in 2016 it moved into a new state‑of‑the‑art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under one roof in Europe. The Francis Crick Institute will be world‑class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
Please apply via ‘Apply’ button above. From £53,025 with benefits, subject to skills and experience.
Senior Bioinformatician employer: The Francis Crick Institute
Contact Detail:
The Francis Crick Institute Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Bioinformatician
✨Tip Number 1
Network like a pro! Reach out to people in the field, attend relevant conferences, and join online forums. The more connections we make, the better our chances of landing that dream job.
✨Tip Number 2
Show off your skills! Prepare a portfolio or a presentation that highlights your past projects and achievements. This will help us stand out during interviews and showcase what we can bring to the table.
✨Tip Number 3
Practice makes perfect! Conduct mock interviews with friends or mentors to refine our responses and boost our confidence. The more we practice, the more comfortable we'll feel when it’s time for the real deal.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure our application gets noticed. Plus, we can keep an eye on new opportunities that pop up in the future.
We think you need these skills to ace Senior Bioinformatician
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the Senior Bioinformatician role. Highlight your experience with single-cell RNA sequencing and spatial transcriptomics, as well as any relevant publications. We want to see how your skills align with our lab's focus on Wnt signalling and cancer research.
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about bioinformatics and how your background fits with Dr Li’s research. Don’t forget to mention your collaborative spirit and any innovative approaches you've taken in past projects.
Showcase Your Communication Skills: Strong written and oral communication skills are key for this role. Include examples of how you've presented complex data at scientific meetings or collaborated with biologists. We love seeing candidates who can make data accessible and engaging!
Apply Through Our Website: We encourage you to apply through our website using the 'Apply' button above. This ensures your application goes directly to us, making it easier for our team to review your materials. We can't wait to see what you bring to the table!
How to prepare for a job interview at The Francis Crick Institute
✨Know Your Research
Before the interview, dive deep into Dr Li's research and the Wnt signalling pathway. Familiarise yourself with the latest publications and findings related to her work. This will not only show your genuine interest but also help you discuss how your skills can contribute to ongoing projects.
✨Showcase Your Skills
Be ready to discuss your experience with single-cell RNA sequencing and spatial transcriptomics. Prepare specific examples of how you've applied bioinformatics and machine learning in past projects. Highlight any innovative approaches you've taken to solve complex biological questions.
✨Collaborative Mindset
Since the role involves working collaboratively, think of examples where you've successfully worked in a team. Be prepared to discuss how you co-designed experiments or helped biologists understand their datasets. Emphasising your collaborative spirit will resonate well with the interviewers.
✨Prepare Questions
Have thoughtful questions ready about the lab's current projects and future directions. This shows your enthusiasm and helps you gauge if the environment is the right fit for you. Ask about the integration of CRISPR screens and how they envision the role evolving within the team.