At a Glance
- Tasks: Conduct groundbreaking research on TLR7 signalling and its role in autoimmune diseases.
- Company: Join the Francis Crick Institute, Europe's largest biomedical research hub.
- Benefits: Enjoy a competitive salary, generous leave, and health support.
- Other info: Dynamic environment fostering innovation and collaboration among top scientists.
- Why this job: Make a real impact in immunology and help improve patient outcomes.
- Qualifications: PhD in Immunology with experience in mouse models and B cell biology.
The predicted salary is between 47500 - 47500 £ per year.
Reports to: Carola Vinuesa
Salary: From £47,500 with benefits subject to skills and experience.
Details of the role:
- Working pattern: This is a full-time, 4 year fixed term position on Crick terms and conditions of employment.
- Application closing date: 2nd of June 2026 at 23.59pm.
About us:
The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world‑class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state‑of‑the‑art infrastructure, cutting‑edge facilities, and a creative and curious culture.
The Research Group:
Dr Vinuesa’s laboratory focuses on understanding the regulation of protective antibody responses and the mechanisms underpinning antibody‑mediated diseases. The research aims to unravel the pathogenesis of autoimmune and allergic diseases, and the processes that control the quality of antibody responses. The goal is to improve the outcomes of patients with autoimmune disorders (AID) with a particular focus on systemic autoimmune diseases like lupus.
The Project:
The purpose of this role is to study the role of different triggers of TLR7 signalling including bacterial and viral infections to the onset of autoimmunity. We will take advantage of a mouse model in which we introduced a rare TLR7 gain‑of‑function variant identified in a child with severe SLE. The mouse model develops lupus‑like disease. The analysis of immune response to pathogens and self‑antigens involves detailed investigation of the cellular and molecular mechanisms.
What you will be doing:
- Undertaking own research project and independently designing and performing experiments to study different triggers of TLR7 signalling including bacterial and viral infections to the onset of autoimmunity.
- Mouse colony management and independently conducting in‑vivo experiments.
- Conducting single cell BCRseq and clonal analysis using bioinformatic pipelines.
- Scientific and technical support for group members.
- Data management and analysis, writing up of manuscripts.
- Presenting at scientific meetings.
- Guiding PhDs in their research.
About you:
- PhD in Immunology or in the final stages of PhD submission.
- Experience in mouse models of immunology, including mouse models of vaccination, allergy, and autoimmunity.
- Experience with mouse husbandry, sample harvesting and processing.
- Expertise in multiple aspects of B cell biology, including germinal center and extrafollicular responses, plasma cell biology, class switch recombination and somatic hypermutation.
- Experience in BCR sequencing and clonal analysis.
- Experience in mucosal immunology and mucosal B cell responses.
- Excellent track record of high‑quality research as evidenced by first author publications in referred journals.
What will you receive:
- Visas: Applicants for this role will be eligible for sponsorship to work in the UK.
- Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
- Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
- Health & Well‑being: 24/7 GP consultation services, occupational health, and mental health support.
- Work‑Life Balance: Back‑up care for dependents and childcare support allowance.
At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed. We are a Disability Confident, Committed employer.
Postdoctoral Fellow – Immunology: TLR7 & Lupus Research employer: The Francis Crick Institute
The Francis Crick Institute is an exceptional employer, offering a dynamic and collaborative environment for researchers to thrive. With state-of-the-art facilities and a commitment to employee well-being, including generous leave and health support, the institute fosters a culture of innovation and inclusivity. As a Postdoctoral Fellow in Immunology, you will have the opportunity to contribute to groundbreaking research while benefiting from professional growth and mentorship in one of Europe's leading biomedical research institutes.
Contact Details:
The Francis Crick Institute Recruitment Team
StudySmarter Expert Advice🤫
We think this is how you could land Postdoctoral Fellow – Immunology: TLR7 & Lupus Research
✨Tip Number 1
Network like a pro! Reach out to current or former researchers at the Francis Crick Institute, especially those in the Vinuesa Lab. A friendly chat can give you insider info and maybe even a referral!
✨Tip Number 2
Prepare for your interview by diving deep into TLR7 signalling and lupus research. Show us you’re not just familiar with the basics but can discuss recent findings and how they relate to the lab's work.
✨Tip Number 3
Practice your presentation skills! You might need to present your research ideas or past work. Make sure you can explain complex concepts clearly and confidently – we love a good communicator!
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen. Plus, it shows you’re serious about joining our team at the Crick.
We think you need these skills to ace Postdoctoral Fellow – Immunology: TLR7 & Lupus Research
Some tips for your application 🫡
Tailor Your Application:Make sure to customise your CV and cover letter for the Postdoctoral Fellow position. Highlight your relevant experience in immunology, especially with TLR7 and lupus research, to show us you’re the perfect fit for our team.
Showcase Your Research Skills:We want to see your scientific prowess! Include details about your previous research projects, particularly those involving mouse models and B cell biology. This will help us understand your expertise and how you can contribute to our lab.
Be Clear and Concise:When writing your application, keep it straightforward. Use clear language and avoid jargon where possible. We appreciate a well-structured application that makes it easy for us to see your qualifications and enthusiasm.
Apply Through Our Website:Don’t forget to submit your application through our official website! It’s the best way for us to receive your materials and ensures you’re considered for this exciting opportunity at the Francis Crick Institute.
How to prepare for a job interview at The Francis Crick Institute
✨Know Your Research
Dive deep into the specifics of TLR7 signalling and its implications in lupus. Be prepared to discuss your previous research experiences, especially those related to mouse models and B cell biology, as this will show your genuine interest and expertise in the field.
✨Showcase Your Skills
Highlight your technical skills, particularly in single cell BCR sequencing and data analysis. Bring examples of your past work or publications that demonstrate your ability to conduct independent research and contribute to the lab's goals.
✨Prepare Thoughtful Questions
Think of insightful questions to ask Dr Vinuesa about her research group and future projects. This not only shows your enthusiasm but also helps you gauge if the lab environment aligns with your career aspirations.
✨Practice Your Presentation
Since presenting at scientific meetings is part of the role, practice summarising your research succinctly. Focus on clarity and confidence, as this will reflect your communication skills and ability to engage with the scientific community.
