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- Tasks: Join our team to explore molecular mechanisms of chromosome replication and conduct cutting-edge research.
- Company: The Francis Crick Institute is Europe's largest biomedical research hub, fostering innovation and collaboration.
- Benefits: Enjoy 28 days annual leave, health support, gym discounts, and a generous pension scheme.
- Why this job: Be part of a dynamic environment that values creativity and collaboration in groundbreaking scientific research.
- Qualifications: PhD in biochemistry or related fields, with experience in molecular biology and protein purification.
- Other info: We encourage diverse applicants and offer support for those needing adjustments during the application process.
The predicted salary is between 45500 - 45500 £ per year.
Salary for this Role:
From £45,500 with benefits, subject to skills and experience.
Job Title:
Postdoctoral Fellow – Costa Lab
Reports to:
Alessandro Costa
Closing Date:
03/Aug/2025 23.59 GMT
Job Description:
Job Title: Postdoctoral Fellow
Details of the role: 2 positions available on 4 yr. FTC, full time.
Salary: From £45,500 pa with benefits, subject to skills and experience
Application closing date: 03/08/25
About us…
The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.
About the role…
The Costa lab currently hosts nine researchers from eight different countries. We focus on the molecular mechanisms of eukaryotic chromosome replication with two main areas of investigation:
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Relication initiation – funded by an 8-year Wellcome Discovery Award starting in September 2025.
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Chromatin replication and epigenetic inheritance – currently funded by the Francis Crick Institute.
We employ in vitro reconstitution with purified proteins (yeast and human) and isolation of endogenous DNA-processing machineries (Xenopus). We use a combination of biochemical and single-particle cryo-EM approaches. We are currently also developing in situ cryo-tomography imaging of replicating nuclei established with frog egg extracts.
We are looking for individuals who share our passion for molecular mechanisms of fundamental cellular processes. Biochemists, molecular biologists and structural biologists (including cryo-tomography scientists) are encouraged to apply.
Click here for further information on the lab and published papers.
What you will be doing…
As a Postdoc at the Crick, you will be:
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using biochemical approaches to reconstitute and/or isolate endogenous replisome assemblies for structural studies.
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validating structures obtained with cryo-EM by generating protein variants for biochemical and fluorescence-based activity assays.
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studying spatial and temporal organisation of replication factories in situ with cryo-tomography.
About you…
The essential criteria you will bring…
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PhD in biochemistry, structural biology, biophysics or related fields.
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Experience in molecular biology and protein purification.
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Technical expertise in biochemical reconstitution or fluorescence imaging technology.
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Experience in establishing biochemical assays.
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Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals.
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Evidence of data presentation at scientific meetings.
To see the complete job description, click here.
To learn more about the team/Group Leader, click here.
About Working at the Crick…
Our values
Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture!
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We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.
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We areopen. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
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We arecollegial. We show respect for one another, work cooperatively and support the wider community.
At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post)please email: people@crick.ac.uk
To find out more about life at the Crick click here.
What will you receive?
At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:
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Visas: Applicants for this role will be eligible for sponsorship to work in the UK
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Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
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Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
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Health & Well-being:
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24/7 GP consultation services.
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Occupational health services and mental health support programs.
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Eye care vouchers and discounted healthcare plans.
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Work-Life Balance:
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Back-up care for dependents.
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Childcare support allowance.
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Annual leave purchase options.
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Crick Networks offering diverse groups’ support, community and inclusive social events.
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Perks:
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Discounted gym memberships, bike-to-work scheme, and shopping discounts.
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Subsidised on-site restaurant and social spaces for team interaction.
Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.
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Postdoctoral Fellow - Costa Lab employer: The Francis Crick Institute
Contact Detail:
The Francis Crick Institute Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Postdoctoral Fellow - Costa Lab
✨Tip Number 1
Familiarise yourself with the latest research and publications from the Costa Lab. Understanding their current projects and methodologies will not only help you in interviews but also demonstrate your genuine interest in their work.
✨Tip Number 2
Network with current or former members of the Costa Lab or the Francis Crick Institute. Engaging with them can provide valuable insights into the lab culture and expectations, which can be beneficial during your application process.
✨Tip Number 3
Prepare to discuss your previous research experiences in detail, especially those related to biochemical reconstitution and fluorescence imaging technology. Be ready to explain how your skills align with the lab's focus areas.
✨Tip Number 4
Showcase your collaborative spirit by highlighting any teamwork experiences in your discussions. The Crick values openness and collegiality, so demonstrating your ability to work well with others will strengthen your candidacy.
We think you need these skills to ace Postdoctoral Fellow - Costa Lab
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in biochemistry, structural biology, or related fields. Emphasise any specific skills that align with the job description, such as protein purification and biochemical reconstitution.
Craft a Strong Cover Letter: Write a cover letter that showcases your passion for molecular mechanisms and your fit for the Costa lab. Mention specific projects or techniques you are excited about and how your background prepares you for this role.
Highlight Publications: Include a section in your application that lists your publications or submitted manuscripts. This demonstrates your track record in research and writing, which is essential for a postdoctoral position.
Showcase Collaboration Skills: Since the Crick values collaboration, mention any experiences where you worked in teams or contributed to group projects. Highlight how you can contribute to the lab's dynamic environment.
How to prepare for a job interview at The Francis Crick Institute
✨Know Your Research
Familiarise yourself with the latest research from the Costa Lab and the Francis Crick Institute. Be prepared to discuss how your background in biochemistry, molecular biology, or structural biology aligns with their current projects.
✨Showcase Your Technical Skills
Highlight your experience in biochemical reconstitution, protein purification, and fluorescence imaging technology. Be ready to provide specific examples of how you've applied these skills in your previous work.
✨Prepare for Collaborative Questions
Since the lab values collaboration, think about past experiences where you worked effectively in a team. Be ready to discuss how you can contribute to a collegial environment and support your colleagues.
✨Demonstrate Your Passion
Express your enthusiasm for molecular mechanisms and fundamental cellular processes. Share why you're excited about the opportunity to work at the Crick and how it aligns with your career goals.
