At a Glance
- Tasks: Lead the development of analytical methods for protein characterisation using mass spectrometry.
- Company: Join T-Therapeutics, a pioneering T cell receptor company from the University of Cambridge.
- Benefits: Competitive salary, collaborative culture, and opportunities for professional growth.
- Other info: Dynamic team environment with mentorship opportunities and career advancement.
- Why this job: Make a real impact in developing transformative medicines for cancer and autoimmune diseases.
- Qualifications: PhD in analytical chemistry or related field with hands-on mass spectrometry experience.
The predicted salary is between 42750 - 52250 £ per year.
T-Therapeutics is a next-generation T cell receptor (TCR) company spun out from the University of Cambridge. The company was created to harness the power of T cell biology, to create safe and effective treatments for cancer and autoimmune disease. T-Therapeutics’ experienced team combines world-leading expertise in mouse genome engineering, single cell genomics, biopharmaceutical drug development, machine-learning and structural biology, anchored in a culture of creativity and collaboration.
T-Therapeutics is developing ‘optimal’ TCR therapeutics using its proprietary OpTiMus® discovery platform, that provides an almost unlimited source of unique, antigen‑specific human TCRs. The company is developing a pipeline of first‑in‑class drugs that are intended to become transformative medicines, reshaping the clinical landscape for patients with cancer or autoimmune diseases.
About the Opportunity
We are seeking an experienced, highly motivated Senior Scientist – Analytical Development to join our Protein Sciences Team. The ideal candidate will bring extensive expertise in Mass Spectrometry (LC‑MS/MS) for protein characterisation and a strong background in developing and implementing analytical methods to support the advancement of pre‑clinical biologics programmes. This role will lead the development of mass spectrometry‑based methods and other characterisation assays for biologics, while also overseeing outsourced methods development and phase appropriate validation to support regulatory submissions.
In this role you will be responsible for:
- Development, optimisation and troubleshooting of analytical methods focused on mass spectrometry for protein characterisation (including intact mass analysis, peptide mapping and glycosylation analysis).
- Development and optimisation of HPLC/UPLC-based methods, including HIC, HILIC, SEC and reverse‑phase chromatography.
- Leading developability and characterisation studies to support pre‑clinical and early development programmes.
- Providing technical oversight of development and validation of outsourced analytical methods in support of future IND/BLA submissions.
- Interpretation, documenting, and presenting data and findings to cross‑functional teams and stakeholders.
- Collaborating within CMC and across multiple teams within the company.
- Mentoring junior colleagues and encouraging development of additional Mass Spectrometry users or system owners.
Qualifications and requirements:
- PhD with industry experience in analytical chemistry, biochemistry or a related field is desired.
- Hands-on experience with mass spectrometry (e.g. LC‑MS, QTOF, Orbitrap) and HPLC/UPLC techniques.
- Strong experience with a range of analytical methods for protein characterisation such as liquid chromatography (e.g. RP, SEC, HIC), capillary electrophoresis would be an advantage.
- Proficiency in data analysis software (e.g. MassLynx, Waters connect, Empower).
- Proven record of leading method development is essential.
- Experience in characterisation of complex biologics is essential.
- Deep understanding of ICH guidelines and experience with IND/BLA submissions would be an advantage.
- Ability to work independently and as part of a team.
- Strong analytical and problem‑solving skills.
Senior Scientist - Analytical Development, Protein Sciences in Cambridge employer: T-Therapeutics Ltd
T-Therapeutics is an exceptional employer, offering a dynamic work environment that fosters creativity and collaboration among its talented team. Located in the vibrant ecosystem of Cambridge, employees benefit from access to cutting-edge research and development opportunities, as well as a strong focus on professional growth and mentorship. With a commitment to developing transformative medicines, T-Therapeutics provides a meaningful and rewarding career path for those passionate about making a difference in the field of biopharmaceuticals.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist - Analytical Development, Protein Sciences in Cambridge
✨Get Involved in Local Research Communities
Tap into local biotechnology meetups and research forums. These are great places to mingle with industry professionals, share your passion, and even discover unadvertised job openings. It's all about getting your face known in the field!
✨Leverage University Alumni Networks
If you're a recent grad, don’t underestimate the power of your university’s alumni network! Reach out to alumni working in biotechnology to gather tips about job openings at companies like T-Therapeutics Ltd. You'd be surprised how willing people are to help out a fellow grad!
✨Show Off Your Projects
Curate a portfolio showcasing any research projects or internships you've completed in biotechnology. This tangible evidence of your skills can really impress employers when you chat with them at networking events or interviews. It's about making that killer first impression!
✨Stay Up-to-Date with Industry Trends
Biotech is a fast-paced field, so keeping yourself updated with the latest advancements is crucial. Attend industry conferences, webinars, or workshops to broaden your knowledge and meet potential employers. Plus, it’ll give you fantastic talking points for your interviews at places like T-Therapeutics Ltd!
We think you need these skills to ace Senior Scientist - Analytical Development, Protein Sciences in Cambridge
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show T-Therapeutics Ltd that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at T-Therapeutics Ltd.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that T-Therapeutics Ltd does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at T-Therapeutics Ltd
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at T-Therapeutics Ltd. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
✨Show Your Teamwork Skills
Biotech often involves collaboration across multiple disciplines. Be ready to share stories that highlight your teamwork and communication skills, especially in research projects. Think about working with different teams at university or any internships – this is where you can show how well you fit into T-Therapeutics Ltd's culture.
✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at T-Therapeutics Ltd. This shows your passion for the industry!
