Find a job 
Featured Companies 
Featured Universities 
For Companies At a Glance
- Tasks: Lead LC-MS/MS bioanalytical programmes and solve complex analytical challenges.
- Company: Join a leading scientific organisation focused on innovative bioanalysis.
- Benefits: Attractive salary, professional development, and opportunities for mentorship.
- Other info: Collaborative environment with a focus on scientific excellence and client engagement.
- Why this job: Make a significant impact in bioanalysis while mentoring the next generation of scientists.
- Qualifications: PhD or MSc with extensive LC-MS/MS experience and strong analytical skills.
The predicted salary is between 60000 - 80000 £ per year.
We are seeking a Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) to act as a subject matter expert across LC-MS/MS bioanalytical programmes supporting PK and PD studies. This role provides scientific leadership across multiple studies, focusing on complex problem-solving, assay strategy, and client engagement.
Key Responsibilities
- Provide scientific leadership and SME support across LC-MS/MS studies
- Lead troubleshooting of complex analytical challenges, including matrix effects, sensitivity limitations, and assay robustness
- Advise on method development, optimisation, and validation strategies
- Support study teams in resolving technical issues and ensuring consistent assay performance
- Contribute to client interactions, including scientific discussions, data interpretation, and method justification
- Support proposals, bid defences, and scientific strategy discussions
- Mentor and support development of laboratory scientists
Technical Expertise
- Strong knowledge of LC-MS/MS theory, including triple quadrupole and HRMS systems
- Experience with sample preparation techniques such as SPE, LLE, protein precipitation, and hybrid workflows
- Deep understanding of quantitative bioanalysis, including calibration strategies, selectivity, and matrix effects
Experience with Complex Modalities
- Peptides and proteins
- Oligonucleotides
- Antibody-drug conjugates and related conjugates
Regulatory and Client Experience
- Extensive experience working under GLP and GCP
- Strong understanding of regulatory guidance (FDA, EMA, MHRA, M10)
- Experience supporting audits and regulatory inspections
- Proven ability to lead scientific discussions with clients and defend analytical approaches and data
- Ability to communicate complex technical issues clearly and challenge client assumptions where appropriate
Qualifications and Experience
- PhD in Analytical Chemistry or related field, or MSc with significant industry experience
- 10 to 15 or more years of LC-MS/MS bioanalysis experience
- Demonstrated expertise in method development, validation, and advanced troubleshooting
Principal Scientist I – LC-MS/MS in Macclesfield employer: Synexa Life Sciences
Contact Detail:
Synexa Life Sciences Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Principal Scientist I – LC-MS/MS in Macclesfield
✨Tip Number 1
Network like a pro! Reach out to your connections in the industry, attend relevant conferences, and engage with professionals on platforms like LinkedIn. We can’t stress enough how important it is to make those personal connections that could lead to job opportunities.
✨Tip Number 2
Prepare for interviews by brushing up on your technical knowledge and being ready to discuss your past experiences in detail. We recommend practising common interview questions related to LC-MS/MS and bioanalysis so you can showcase your expertise confidently.
✨Tip Number 3
Don’t just wait for job openings to pop up! Be proactive and reach out to companies you admire, even if they’re not advertising positions. A well-crafted email expressing your interest can sometimes open doors we didn’t even know existed.
✨Tip Number 4
Finally, apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, we love hearing from passionate candidates who are eager to contribute to our team!
We think you need these skills to ace Principal Scientist I – LC-MS/MS in Macclesfield
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights your experience with LC-MS/MS and any relevant projects you've led. We want to see how your background aligns with the role, so don’t be shy about showcasing your expertise in bioanalysis and method development!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're the perfect fit for the Principal Scientist role. Share specific examples of your problem-solving skills and client engagement experiences that relate to the job description.
Showcase Your Technical Skills: In your application, make sure to highlight your technical expertise in LC-MS/MS, especially with complex modalities like peptides and proteins. We’re looking for someone who can tackle analytical challenges, so give us the details on your troubleshooting successes!
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way for us to receive your application and ensures you’re considered for the role. Plus, it shows us you’re keen on joining the StudySmarter team!
How to prepare for a job interview at Synexa Life Sciences
✨Know Your LC-MS/MS Inside Out
Make sure you brush up on your knowledge of LC-MS/MS theory and applications. Be prepared to discuss specific techniques like sample preparation methods and how they relate to the role. This will show that you’re not just familiar with the basics, but you truly understand the complexities involved.
✨Prepare for Technical Challenges
Anticipate questions about troubleshooting complex analytical challenges. Think of examples from your past experience where you successfully resolved issues like matrix effects or sensitivity limitations. Sharing these stories will demonstrate your problem-solving skills and technical expertise.
✨Engage in Scientific Discussions
Since client engagement is key, practice articulating your thoughts on data interpretation and method justification. Prepare to defend your analytical approaches and challenge assumptions when necessary. This will highlight your ability to communicate complex ideas clearly and effectively.
✨Showcase Your Leadership Skills
As a Principal Scientist, mentoring and supporting others is crucial. Be ready to discuss your experience in leading teams and developing laboratory scientists. Share specific examples of how you've guided others through method development or validation processes to illustrate your leadership capabilities.